ampyrone-4507 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the ampyrone-4507 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APAF1 apoptotic peptidase activating factor 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATN1 atrophin 1
ATP10B ATPase, class V, type 10B
BHMT2 betaine--homocysteine S-methyltransferase 2
BMP10 bone morphogenetic protein 10
CALHM2 calcium homeostasis modulator 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD52 CD52 molecule
CEND1 cell cycle exit and neuronal differentiation 1
CGA glycoprotein hormones, alpha polypeptide
CHRDL1 chordin-like 1
CLCA1 chloride channel accessory 1
CLTCL1 clathrin, heavy chain-like 1
CNGB3 cyclic nucleotide gated channel beta 3
CPED1 cadherin-like and PC-esterase domain containing 1
CPZ carboxypeptidase Z
CREB3L1 cAMP responsive element binding protein 3-like 1
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
DACH1 dachshund family transcription factor 1
DGCR8 DGCR8 microprocessor complex subunit
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
EGFL7 EGF-like-domain, multiple 7
ERAP1 endoplasmic reticulum aminopeptidase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGF5 fibroblast growth factor 5
FGFR2 fibroblast growth factor receptor 2
FGFR4 fibroblast growth factor receptor 4
FLT1 fms-related tyrosine kinase 1
FOXE1 forkhead box E1
FRS3 fibroblast growth factor receptor substrate 3
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GK2 glycerol kinase 2
GK3P glycerol kinase 3 pseudogene
GPRC5D G protein-coupled receptor, class C, group 5, member D
GREB1L growth regulation by estrogen in breast cancer-like
HAS1 hyaluronan synthase 1
HHIPL2 HHIP-like 2
HOMER3 homer scaffolding protein 3
HPX hemopexin
HSPG2 heparan sulfate proteoglycan 2
ICA1 islet cell autoantigen 1, 69kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KANSL3 KAT8 regulatory NSL complex subunit 3
KIAA1467 KIAA1467
KIF21B kinesin family member 21B
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KISS1 KiSS-1 metastasis-suppressor
KMT2A lysine (K)-specific methyltransferase 2A
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
MCF2L MCF.2 cell line derived transforming sequence-like
MED16 mediator complex subunit 16
MMP11 matrix metallopeptidase 11
MOCS1 molybdenum cofactor synthesis 1
MTMR3 myotubularin related protein 3
NLE1 notchless homolog 1 (Drosophila)
NOP16 NOP16 nucleolar protein
NOVA2 neuro-oncological ventral antigen 2
NPY neuropeptide Y
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PAPPA2 pappalysin 2
PDLIM5 PDZ and LIM domain 5
PELI2 pellino E3 ubiquitin protein ligase family member 2
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
POM121L2 POM121 transmembrane nucleoporin-like 2
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PPP5C protein phosphatase 5, catalytic subunit
PRDM14 PR domain containing 14
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB31 RAB31, member RAS oncogene family
RAB33A RAB33A, member RAS oncogene family
RAD51B RAD51 paralog B
RECQL5 RecQ protein-like 5
RPL10 ribosomal protein L10
RUNX1 runt-related transcription factor 1
RYR1 ryanodine receptor 1 (skeletal)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SFTPB surfactant protein B
SORBS2 sorbin and SH3 domain containing 2
SP110 SP110 nuclear body protein
SPRR1A small proline-rich protein 1A
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STAB2 stabilin 2
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBX2 T-box 2
TJAP1 tight junction associated protein 1 (peripheral)
TNS4 tensin 4
UPK3B uroplakin 3B
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VIPR2 vasoactive intestinal peptide receptor 2

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AGO4 argonaute RISC catalytic component 4
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
AMT aminomethyltransferase
ANKRD36B ankyrin repeat domain 36B
AP1AR adaptor-related protein complex 1 associated regulatory protein
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATAD5 ATPase family, AAA domain containing 5
ATG10 autophagy related 10
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AXIN1 axin 1
BAX BCL2-associated X protein
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BICC1 BicC family RNA binding protein 1
BTF3P12 basic transcription factor 3 pseudogene 12
CCL27 chemokine (C-C motif) ligand 27
CDHR2 cadherin-related family member 2
CHM choroideremia (Rab escort protein 1)
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNTNAP3B contactin associated protein-like 3B
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
CORT cortistatin
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DEPDC1 DEP domain containing 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM169A family with sequence similarity 169, member A
FKBP5 FK506 binding protein 5
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSTCD glutathione S-transferase, C-terminal domain containing
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1D histone cluster 1, H1d
HIST1H2BJ histone cluster 1, H2bj
HIST1H4C histone cluster 1, H4c
HIST1H4D histone cluster 1, H4d
IFI6 interferon, alpha-inducible protein 6
IL17RA interleukin 17 receptor A
KIRREL kin of IRRE like (Drosophila)
KRT86 keratin 86, type II
LINC00341 long intergenic non-protein coding RNA 341
LOC257152 uncharacterized LOC257152
LPAR3 lysophosphatidic acid receptor 3
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
MANEA mannosidase, endo-alpha
MAP9 microtubule-associated protein 9
MCC mutated in colorectal cancers
MED18 mediator complex subunit 18
METTL16 methyltransferase like 16
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MIS18BP1 MIS18 binding protein 1
MRPL44 mitochondrial ribosomal protein L44
MUC3A mucin 3A, cell surface associated
MXRA8 matrix-remodelling associated 8
NABP1 nucleic acid binding protein 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NT5M 5',3'-nucleotidase, mitochondrial
PCDHA9 protocadherin alpha 9
POLL polymerase (DNA directed), lambda
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRR14L proline rich 14-like
RAP1GAP2 RAP1 GTPase activating protein 2
RASA2 RAS p21 protein activator 2
RFX7 regulatory factor X, 7
SKI SKI proto-oncogene
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNORA21 small nucleolar RNA, H/ACA box 21
SNX16 sorting nexin 16
SP1 Sp1 transcription factor
SPIN1 spindlin 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TBC1D19 TBC1 domain family, member 19
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEX15 testis expressed 15
THRAP3 thyroid hormone receptor associated protein 3
TIPRL TOR signaling pathway regulator
TMEM209 transmembrane protein 209
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
USP36 ubiquitin specific peptidase 36
VASH2 vasohibin 2
WDR76 WD repeat domain 76
ZFP30 ZFP30 zinc finger protein
ZNF10 zinc finger protein 10
ZNF124 zinc finger protein 124
ZNF184 zinc finger protein 184
ZNF428 zinc finger protein 428
ZNF652 zinc finger protein 652
ZNF668 zinc finger protein 668