amprolium-4825 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the amprolium-4825 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANGPTL2 angiopoietin-like 2
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMC4 armadillo repeat containing 4
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BAIAP3 BAI1-associated protein 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CARF calcium responsive transcription factor
CD47 CD47 molecule
CDC42 cell division cycle 42
CHD5 chromodomain helicase DNA binding protein 5
COL1A1 collagen, type I, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CTNS cystinosin, lysosomal cystine transporter
DCTN1 dynactin 1
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DUSP6 dual specificity phosphatase 6
EFNB3 ephrin-B3
EPHB1 EPH receptor B1
ERAP1 endoplasmic reticulum aminopeptidase 1
FGF18 fibroblast growth factor 18
FMO5 flavin containing monooxygenase 5
FOXG1 forkhead box G1
FSCN3 fascin actin-bundling protein 3, testicular
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJB3 gap junction protein, beta 3, 31kDa
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GP2 glycoprotein 2 (zymogen granule membrane)
GPR173 G protein-coupled receptor 173
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H4E histone cluster 1, H4e
HLA-DMB major histocompatibility complex, class II, DM beta
HOXB6 homeobox B6
HR hair growth associated
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
ICA1 islet cell autoantigen 1, 69kDa
IFNA14 interferon, alpha 14
IGFBP5 insulin-like growth factor binding protein 5
IL11 interleukin 11
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KLHL20 kelch-like family member 20
MFSD11 major facilitator superfamily domain containing 11
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MID1 midline 1
MMP25 matrix metallopeptidase 25
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NT5M 5',3'-nucleotidase, mitochondrial
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NXPE3 neurexophilin and PC-esterase domain family, member 3
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OSGIN2 oxidative stress induced growth inhibitor family member 2
PCLO piccolo presynaptic cytomatrix protein
PHC3 polyhomeotic homolog 3 (Drosophila)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PMFBP1 polyamine modulated factor 1 binding protein 1
PML promyelocytic leukemia
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
POLR2J4 polymerase (RNA) II (DNA directed) polypeptide J4, pseudogene
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRDM2 PR domain containing 2, with ZNF domain
PTCRA pre T-cell antigen receptor alpha
PTPRD protein tyrosine phosphatase, receptor type, D
RAB6B RAB6B, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RUNX1 runt-related transcription factor 1
RUSC2 RUN and SH3 domain containing 2
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC7A10 solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
SMAD3 SMAD family member 3
SOS2 son of sevenless homolog 2 (Drosophila)
TAOK2 TAO kinase 2
TEF thyrotrophic embryonic factor
TLE4 transducin-like enhancer of split 4
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TPMT thiopurine S-methyltransferase
TRIM36 tripartite motif containing 36
TSC22D2 TSC22 domain family, member 2
TTLL3 tubulin tyrosine ligase-like family member 3
USP22 ubiquitin specific peptidase 22
UTRN utrophin
ZFHX2 zinc finger homeobox 2
ZFP30 ZFP30 zinc finger protein
ZFX zinc finger protein, X-linked
ZNF480 zinc finger protein 480
ZNF609 zinc finger protein 609

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ARL15 ADP-ribosylation factor-like 15
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C1ORF159 chromosome 1 open reading frame 159
CA11 carbonic anhydrase XI
CAPG capping protein (actin filament), gelsolin-like
CHPF chondroitin polymerizing factor
CKB creatine kinase, brain
CLDN15 claudin 15
CNN2 calponin 2
CORO7 coronin 7
CSTA cystatin A (stefin A)
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DEAF1 DEAF1 transcription factor
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSCAM Down syndrome cell adhesion molecule
ERN2 endoplasmic reticulum to nucleus signaling 2
ERO1L ERO1-like (S. cerevisiae)
FAM189A2 family with sequence similarity 189, member A2
FKBP10 FK506 binding protein 10, 65 kDa
GCHFR GTP cyclohydrolase I feedback regulator
GEMIN8 gem (nuclear organelle) associated protein 8
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX2 glutathione peroxidase 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
INO80D INO80 complex subunit D
KDM5C lysine (K)-specific demethylase 5C
KRT8P12 keratin 8 pseudogene 12
LAMA3 laminin, alpha 3
LARP6 La ribonucleoprotein domain family, member 6
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MANBA mannosidase, beta A, lysosomal
MED15 mediator complex subunit 15
MEFV Mediterranean fever
MITF microphthalmia-associated transcription factor
MKS1 Meckel syndrome, type 1
MOGS mannosyl-oligosaccharide glucosidase
MOSPD3 motile sperm domain containing 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTHFSD methenyltetrahydrofolate synthetase domain containing
MTMR12 myotubularin related protein 12
MUM1 melanoma associated antigen (mutated) 1
MYO1D myosin ID
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL12 nucleolar protein 12
NRSN2 neurensin 2
NT5C 5', 3'-nucleotidase, cytosolic
NTHL1 nth endonuclease III-like 1 (E. coli)
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
ODF2 outer dense fiber of sperm tails 2
PACS1 phosphofurin acidic cluster sorting protein 1
PANK4 pantothenate kinase 4
PCDHB3 protocadherin beta 3
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
POLD2 polymerase (DNA directed), delta 2, accessory subunit
PRSS16 protease, serine, 16 (thymus)
PTPRU protein tyrosine phosphatase, receptor type, U
RPAP1 RNA polymerase II associated protein 1
RPL10L ribosomal protein L10-like
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
RUNDC3B RUN domain containing 3B
SCAMP5 secretory carrier membrane protein 5
SCGB2A2 secretoglobin, family 2A, member 2
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SDC3 syndecan 3
SKI SKI proto-oncogene
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SNIP1 Smad nuclear interacting protein 1
SPAG4 sperm associated antigen 4
STAG3 stromal antigen 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TBC1D17 TBC1 domain family, member 17
TCTA T-cell leukemia translocation altered
TDRD7 tudor domain containing 7
THOP1 thimet oligopeptidase 1
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPO translocator protein (18kDa)
TUBA3C tubulin, alpha 3c
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
VWA1 von Willebrand factor A domain containing 1
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF324 zinc finger protein 324
ZNF701 zinc finger protein 701
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862