amprolium-4241 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the amprolium-4241 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ARHGAP28 Rho GTPase activating protein 28
BTBD18 BTB (POZ) domain containing 18
BTG2 BTG family, member 2
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAMK4 calcium/calmodulin-dependent protein kinase IV
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CASQ2 calsequestrin 2 (cardiac muscle)
CCDC7 coiled-coil domain containing 7
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal)
CIITA class II, major histocompatibility complex, transactivator
CLCN6 chloride channel, voltage-sensitive 6
CLSTN3 calsyntenin 3
CNTNAP2 contactin associated protein-like 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
CREBZF CREB/ATF bZIP transcription factor
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTSZ cathepsin Z
CYSLTR1 cysteinyl leukotriene receptor 1
DHRS12 dehydrogenase/reductase (SDR family) member 12
DHRS7 dehydrogenase/reductase (SDR family) member 7
DOK4 docking protein 4
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EMC3 ER membrane protein complex subunit 3
EPHA5 EPH receptor A5
FABP7 fatty acid binding protein 7, brain
FBXO11 F-box protein 11
FLT1 fms-related tyrosine kinase 1
FRMD1 FERM domain containing 1
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GLRA2 glycine receptor, alpha 2
GPATCH4 G patch domain containing 4
GPM6B glycoprotein M6B
GPR21 G protein-coupled receptor 21
HDGFRP3 hepatoma-derived growth factor, related protein 3
HHAT hedgehog acyltransferase
IQGAP2 IQ motif containing GTPase activating protein 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIF24 kinesin family member 24
KLF4 Kruppel-like factor 4 (gut)
LAT2 linker for activation of T cells family, member 2
LDB2 LIM domain binding 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMNB1 lamin B1
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAGEC3 melanoma antigen family C3
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAPK10 mitogen-activated protein kinase 10
MFAP3L microfibrillar-associated protein 3-like
MIER2 mesoderm induction early response 1, family member 2
MLX MLX, MAX dimerization protein
MME membrane metallo-endopeptidase
MST1L macrophage stimulating 1-like
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOP14-AS1 NOP14 antisense RNA 1
NTN1 netrin 1
NTNG1 netrin G1
OSGIN1 oxidative stress induced growth inhibitor 1
PAOX polyamine oxidase (exo-N4-amino)
PHC3 polyhomeotic homolog 3 (Drosophila)
PHF14 PHD finger protein 14
PITX2 paired-like homeodomain 2
PKP4 plakophilin 4
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTBP3 polypyrimidine tract binding protein 3
RAB14 RAB14, member RAS oncogene family
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RB1 retinoblastoma 1
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RNF32 ring finger protein 32
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPS14 ribosomal protein S14
SAFB scaffold attachment factor B
SARM1 sterile alpha and TIR motif containing 1
SEC14L4 SEC14-like 4 (S. cerevisiae)
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO5A1 solute carrier organic anion transporter family, member 5A1
SMAD4 SMAD family member 4
SRF serum response factor (c-fos serum response element-binding transcription factor)
SSTR4 somatostatin receptor 4
SWAP70 SWAP switching B-cell complex 70kDa subunit
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TMEM63A transmembrane protein 63A
TNIK TRAF2 and NCK interacting kinase
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
TSC22D2 TSC22 domain family, member 2
UBE2I ubiquitin-conjugating enzyme E2I
VPS9D1 VPS9 domain containing 1
ZC2HC1C zinc finger, C2HC-type containing 1C
ZFP64 ZFP64 zinc finger protein
ZNF214 zinc finger protein 214

decreased expression

Symbol Name
ADGRB2 adhesion G protein-coupled receptor B2
ALOX12 arachidonate 12-lipoxygenase
ALPK1 alpha-kinase 1
APOL6 apolipoprotein L, 6
ATAT1 alpha tubulin acetyltransferase 1
C14ORF105 chromosome 14 open reading frame 105
C22ORF46 chromosome 22 open reading frame 46
C7ORF69 chromosome 7 open reading frame 69
CBX8 chromobox homolog 8
CCL2 chemokine (C-C motif) ligand 2
CD70 CD70 molecule
CDON cell adhesion associated, oncogene regulated
CES3 carboxylesterase 3
CLCA1 chloride channel accessory 1
CLDN1 claudin 1
CNGB3 cyclic nucleotide gated channel beta 3
CORO1A coronin, actin binding protein, 1A
CPNE7 copine VII
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCR2 chemokine (C-X-C motif) receptor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM155A family with sequence similarity 155, member A
FGF23 fibroblast growth factor 23
FKBP8 FK506 binding protein 8, 38kDa
FLT4 fms-related tyrosine kinase 4
FRMPD1 FERM and PDZ domain containing 1
FRS3 fibroblast growth factor receptor substrate 3
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLS2 glutaminase 2 (liver, mitochondrial)
GRM4 glutamate receptor, metabotropic 4
HAMP hepcidin antimicrobial peptide
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIST1H2BN histone cluster 1, H2bn
HPR haptoglobin-related protein
IL36RN interleukin 36 receptor antagonist
IRF2BP1 interferon regulatory factor 2 binding protein 1
KANSL3 KAT8 regulatory NSL complex subunit 3
KIAA0319L KIAA0319-like
KIF13B kinesin family member 13B
KLF13 Kruppel-like factor 13
KRT8P12 keratin 8 pseudogene 12
LAX1 lymphocyte transmembrane adaptor 1
LIME1 Lck interacting transmembrane adaptor 1
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00597 long intergenic non-protein coding RNA 597
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LOC100287590 uncharacterized LOC100287590
LY6D lymphocyte antigen 6 complex, locus D
MFGE8 milk fat globule-EGF factor 8 protein
MRPS18C mitochondrial ribosomal protein S18C
MTSS1L metastasis suppressor 1-like
MYL9 myosin, light chain 9, regulatory
MYO15A myosin XVA
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2
NTSR1 neurotensin receptor 1 (high affinity)
ODF2 outer dense fiber of sperm tails 2
OSBP2 oxysterol binding protein 2
PAQR6 progestin and adipoQ receptor family member VI
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDE8B phosphodiesterase 8B
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLBD1 phospholipase B domain containing 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PODNL1 podocan-like 1
POM121 POM121 transmembrane nucleoporin
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRM2 protamine 2
PRSS53 protease, serine, 53
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RIBC2 RIB43A domain with coiled-coils 2
RNF39 ring finger protein 39
SDC3 syndecan 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SOX12 SRY (sex determining region Y)-box 12
STAG3L1 stromal antigen 3-like 1 (pseudogene)
STARD5 StAR-related lipid transfer (START) domain containing 5
STEAP4 STEAP family member 4
TBKBP1 TBK1 binding protein 1
TESPA1 thymocyte expressed, positive selection associated 1
TEX15 testis expressed 15
TIGD6 tigger transposable element derived 6
TINAGL1 tubulointerstitial nephritis antigen-like 1
TLN1 talin 1
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNS2 tensin 2
TSNAXIP1 translin-associated factor X interacting protein 1
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP20 ubiquitin specific peptidase 20
WDR25 WD repeat domain 25
WNT1 wingless-type MMTV integration site family, member 1
XAB2 XPA binding protein 2
ZYX zyxin