amitriptyline-6353 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the amitriptyline-6353 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
AMT aminomethyltransferase
ANKLE2 ankyrin repeat and LEM domain containing 2
APOH apolipoprotein H (beta-2-glycoprotein I)
APOL6 apolipoprotein L, 6
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARRB2 arrestin, beta 2
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BBC3 BCL2 binding component 3
BIN1 bridging integrator 1
BIRC3 baculoviral IAP repeat containing 3
BRWD1 bromodomain and WD repeat domain containing 1
C1ORF116 chromosome 1 open reading frame 116
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CFLAR CASP8 and FADD-like apoptosis regulator
CNR2 cannabinoid receptor 2 (macrophage)
CPNE7 copine VII
CTAGE5 CTAGE family, member 5
CTNND2 catenin (cadherin-associated protein), delta 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXXC4 CXXC finger protein 4
CYR61 cysteine-rich, angiogenic inducer, 61
DENND3 DENN/MADD domain containing 3
DICER1 dicer 1, ribonuclease type III
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
ETV5 ets variant 5
FGL2 fibrinogen-like 2
FOSL2 FOS-like antigen 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GBP1 guanylate binding protein 1, interferon-inducible
GPR107 G protein-coupled receptor 107
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXC10 homeobox C10
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IFT122 intraflagellar transport 122
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL6 interleukin 6
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCTD13 potassium channel tetramerization domain containing 13
MAGEB2 melanoma antigen family B2
MAK male germ cell-associated kinase
MINK1 misshapen-like kinase 1
MST1L macrophage stimulating 1-like
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOX1 NADPH oxidase 1
OSMR oncostatin M receptor
PAWR PRKC, apoptosis, WT1, regulator
PDE4DIP phosphodiesterase 4D interacting protein
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PHF1 PHD finger protein 1
PHF20 PHD finger protein 20
PLCD1 phospholipase C, delta 1
PNMA2 paraneoplastic Ma antigen 2
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PQBP1 polyglutamine binding protein 1
PTPRU protein tyrosine phosphatase, receptor type, U
RAB36 RAB36, member RAS oncogene family
RAB3B RAB3B, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS12 regulator of G-protein signaling 12
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPL10L ribosomal protein L10-like
RUNX1-IT1 RUNX1 intronic transcript 1
SAMD4A sterile alpha motif domain containing 4A
SDF2L1 stromal cell-derived factor 2-like 1
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERGEF secretion regulating guanine nucleotide exchange factor
SIDT2 SID1 transmembrane family, member 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SPATA5L1 spermatogenesis associated 5-like 1
STBD1 starch binding domain 1
STK24 serine/threonine kinase 24
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TGFB2 transforming growth factor, beta 2
THBD thrombomodulin
TMEM231 transmembrane protein 231
TMEM50B transmembrane protein 50B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRAK1 trafficking protein, kinesin binding 1
TRIO trio Rho guanine nucleotide exchange factor
UBE4B ubiquitination factor E4B
VASP vasodilator-stimulated phosphoprotein
WIZ widely interspaced zinc finger motifs
ZKSCAN1 zinc finger with KRAB and SCAN domains 1
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ANOS1 anosmin 1
ARMCX2 armadillo repeat containing, X-linked 2
ATF7IP2 activating transcription factor 7 interacting protein 2
ATP10D ATPase, class V, type 10D
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAK1 BCL2-antagonist/killer 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BTF3P12 basic transcription factor 3 pseudogene 12
C17ORF85 chromosome 17 open reading frame 85
C7ORF49 chromosome 7 open reading frame 49
CAPN5 calpain 5
CENPO centromere protein O
CFAP44 cilia and flagella associated protein 44
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CISH cytokine inducible SH2-containing protein
CLDN11 claudin 11
CSRNP3 cysteine-serine-rich nuclear protein 3
CXCL3 chemokine (C-X-C motif) ligand 3
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DDN dendrin
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DTX4 deltex 4, E3 ubiquitin ligase
DZANK1 double zinc ribbon and ankyrin repeat domains 1
E2F8 E2F transcription factor 8
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
FAM86C1 family with sequence similarity 86, member C1
FOXC1 forkhead box C1
FUZ fuzzy planar cell polarity protein
GLT8D2 glycosyltransferase 8 domain containing 2
GMEB1 glucocorticoid modulatory element binding protein 1
GRAMD1B GRAM domain containing 1B
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HDAC7 histone deacetylase 7
HOXA6 homeobox A6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL11RA interleukin 11 receptor, alpha
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA0753 KIAA0753
KIF13B kinesin family member 13B
KLHL26 kelch-like family member 26
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MYOZ3 myozenin 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NPY1R neuropeptide Y receptor Y1
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PC pyruvate carboxylase
PCTP phosphatidylcholine transfer protein
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PTGFR prostaglandin F receptor (FP)
RAB3A RAB3A, member RAS oncogene family
RGCC regulator of cell cycle
RIN1 Ras and Rab interactor 1
RNF2 ring finger protein 2
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCG2 secretogranin II
SCGB2A2 secretoglobin, family 2A, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
SELENBP1 selenium binding protein 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SLC25A40 solute carrier family 25, member 40
SLC35F6 solute carrier family 35, member F6
SMA4 glucuronidase, beta pseudogene
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SPAG4 sperm associated antigen 4
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SYNPO synaptopodin
TAGLN transgelin
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TMEM8A transmembrane protein 8A
TMOD3 tropomodulin 3 (ubiquitous)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAPPC11 trafficking protein particle complex 11
TRIM66 tripartite motif containing 66
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
TSKU tsukushi, small leucine rich proteoglycan
TSPAN8 tetraspanin 8
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR18 WD repeat domain 18
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZBTB48 zinc finger and BTB domain containing 48
ZNF571 zinc finger protein 571
ZNF668 zinc finger protein 668
ZNF862 zinc finger protein 862