amiprilose-3339 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the amiprilose-3339 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
ADORA1 adenosine A1 receptor
ALDOB aldolase B, fructose-bisphosphate
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BCAM basal cell adhesion molecule (Lutheran blood group)
BIRC7 baculoviral IAP repeat containing 7
BTF3P11 basic transcription factor 3 pseudogene 11
C1ORF54 chromosome 1 open reading frame 54
C21ORF2 chromosome 21 open reading frame 2
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC88A coiled-coil domain containing 88A
CD1E CD1e molecule
CD22 CD22 molecule
CD7 CD7 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CES3 carboxylesterase 3
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CLIC5 chloride intracellular channel 5
CTSZ cathepsin Z
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DEF6 differentially expressed in FDCP 6 homolog (mouse)
EHD1 EH-domain containing 1
EPHB1 EPH receptor B1
FABP7 fatty acid binding protein 7, brain
FAM198B family with sequence similarity 198, member B
FGF2 fibroblast growth factor 2 (basic)
FGFBP1 fibroblast growth factor binding protein 1
FHL1 four and a half LIM domains 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GLDC glycine dehydrogenase (decarboxylating)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HABP2 hyaluronan binding protein 2
HAND1 heart and neural crest derivatives expressed 1
HAVCR1 hepatitis A virus cellular receptor 1
HMOX1 heme oxygenase 1
IQCC IQ motif containing C
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KIF24 kinesin family member 24
KRT1 keratin 1, type II
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LDHC lactate dehydrogenase C
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MVB12B multivesicular body subunit 12B
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEUROD4 neuronal differentiation 4
NKX2-5 NK2 homeobox 5
NPR1 natriuretic peptide receptor 1
NPR2 natriuretic peptide receptor 2
NTF3 neurotrophin 3
OMD osteomodulin
OR2B6 olfactory receptor, family 2, subfamily B, member 6
OSMR oncostatin M receptor
PARD6B par-6 family cell polarity regulator beta
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
POM121L2 POM121 transmembrane nucleoporin-like 2
POMT2 protein-O-mannosyltransferase 2
PRKCA protein kinase C, alpha
PRKCE protein kinase C, epsilon
RAD52 RAD52 homolog (S. cerevisiae)
RASA3 RAS p21 protein activator 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RERE arginine-glutamic acid dipeptide (RE) repeats
RGS10 regulator of G-protein signaling 10
RND1 Rho family GTPase 1
SAMD4A sterile alpha motif domain containing 4A
SARM1 sterile alpha and TIR motif containing 1
SCAND2P SCAN domain containing 2 pseudogene
SEC24D SEC24 family member D
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SPRED2 sprouty-related, EVH1 domain containing 2
SUGP1 SURP and G patch domain containing 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
SYT11 synaptotagmin XI
TCF20 transcription factor 20 (AR1)
TGM2 transglutaminase 2
TLDC1 TBC/LysM-associated domain containing 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TP63 tumor protein p63
TPSG1 tryptase gamma 1
TRIM68 tripartite motif containing 68
TSC22D2 TSC22 domain family, member 2
TSKS testis-specific serine kinase substrate
WDFY3 WD repeat and FYVE domain containing 3
WDTC1 WD and tetratricopeptide repeats 1
XPNPEP2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
ZNF117 zinc finger protein 117

decreased expression

Symbol Name
ARID3B AT rich interactive domain 3B (BRIGHT-like)
AXIN1 axin 1
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCAS1 breast carcinoma amplified sequence 1
BFSP1 beaded filament structural protein 1, filensin
C9ORF9 chromosome 9 open reading frame 9
CCDC85C coiled-coil domain containing 85C
CCNK cyclin K
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CDK18 cyclin-dependent kinase 18
CEP97 centrosomal protein 97kDa
CLCN6 chloride channel, voltage-sensitive 6
COPZ2 coatomer protein complex, subunit zeta 2
CUZD1 CUB and zona pellucida-like domains 1
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DIXDC1 DIX domain containing 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSCAM Down syndrome cell adhesion molecule
DUSP5 dual specificity phosphatase 5
ELOVL4 ELOVL fatty acid elongase 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FAM63A family with sequence similarity 63, member A
FBXO31 F-box protein 31
GAB2 GRB2-associated binding protein 2
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GFI1 growth factor independent 1 transcription repressor
GMPR guanosine monophosphate reductase
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2BC histone cluster 1, H2bc
HOXC10 homeobox C10
HOXC8 homeobox C8
IL22 interleukin 22
IQSEC2 IQ motif and Sec7 domain 2
ITPKB inositol-trisphosphate 3-kinase B
LIME1 Lck interacting transmembrane adaptor 1
LPXN leupaxin
LRP2 low density lipoprotein receptor-related protein 2
LRRC8E leucine rich repeat containing 8 family, member E
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MORC4 MORC family CW-type zinc finger 4
MTERF4 mitochondrial transcription termination factor 4
MYOZ3 myozenin 3
N4BP3 NEDD4 binding protein 3
NHEJ1 nonhomologous end-joining factor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NPM3 nucleophosmin/nucleoplasmin 3
NRSN2 neurensin 2
OGFRL1 opioid growth factor receptor-like 1
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
ORAI3 ORAI calcium release-activated calcium modulator 3
OTUD3 OTU deubiquitinase 3
PADI1 peptidyl arginine deiminase, type I
PARD6A par-6 family cell polarity regulator alpha
PCDHA6 protocadherin alpha 6
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
PMEL premelanosome protein
POPDC3 popeye domain containing 3
PRPH peripherin
PRSS22 protease, serine, 22
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF126P1 ring finger protein 126 pseudogene 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC12A8 solute carrier family 12, member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SPIDR scaffolding protein involved in DNA repair
STON1 stonin 1
SUN2 Sad1 and UNC84 domain containing 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TET3 tet methylcytosine dioxygenase 3
THRB thyroid hormone receptor, beta
TLR5 toll-like receptor 5
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM53 transmembrane protein 53
TRAIP TRAF interacting protein
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2
USP27X ubiquitin specific peptidase 27, X-linked
USP6NL USP6 N-terminal like
VIPR1 vasoactive intestinal peptide receptor 1
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WDR25 WD repeat domain 25
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBTB6 zinc finger and BTB domain containing 6
ZNF205 zinc finger protein 205
ZNF250 zinc finger protein 250
ZNF324 zinc finger protein 324
ZNF35 zinc finger protein 35
ZNF358 zinc finger protein 358
ZNF747 zinc finger protein 747