aminoglutethimide-7463 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the aminoglutethimide-7463 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACBD4 acyl-CoA binding domain containing 4
ALDOB aldolase B, fructose-bisphosphate
ALPK1 alpha-kinase 1
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOE apolipoprotein E
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARNT aryl hydrocarbon receptor nuclear translocator
ART1 ADP-ribosyltransferase 1
ATAD2B ATPase family, AAA domain containing 2B
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C19ORF66 chromosome 19 open reading frame 66
C5AR2 complement component 5a receptor 2
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CC2D1A coiled-coil and C2 domain containing 1A
CD70 CD70 molecule
CD83 CD83 molecule
CDC14A cell division cycle 14A
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CXCR4 chemokine (C-X-C motif) receptor 4
DOC2A double C2-like domains, alpha
DOCK6 dedicator of cytokinesis 6
EGFL7 EGF-like-domain, multiple 7
ELN elastin
EPHA1 EPH receptor A1
FAM65A family with sequence similarity 65, member A
GID4 GID complex subunit 4
GLP1R glucagon-like peptide 1 receptor
GPRASP1 G protein-coupled receptor associated sorting protein 1
GSPT1 G1 to S phase transition 1
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HCRP1 hepatocellular carcinoma-related HCRP1
HLA-C major histocompatibility complex, class I, C
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXD1 homeobox D1
IFI6 interferon, alpha-inducible protein 6
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IQCK IQ motif containing K
ISG20 interferon stimulated exonuclease gene 20kDa
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KANSL3 KAT8 regulatory NSL complex subunit 3
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLF7 Kruppel-like factor 7 (ubiquitous)
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT8 keratin 8, type II
LAMB1 laminin, beta 1
LPIN1 lipin 1
MAGEA3 melanoma antigen family A3
MERTK MER proto-oncogene, tyrosine kinase
NCOR2 nuclear receptor corepressor 2
NOD1 nucleotide-binding oligomerization domain containing 1
NPAS2 neuronal PAS domain protein 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRSN2 neurensin 2
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2
PASK PAS domain containing serine/threonine kinase
PDCD6 programmed cell death 6
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PQLC2 PQ loop repeat containing 2
PRAMEF11 PRAME family member 11
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTN pleiotrophin
R3HDM1 R3H domain containing 1
RBM12 RNA binding motif protein 12
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS12 regulator of G-protein signaling 12
RNF2 ring finger protein 2
RNFT2 ring finger protein, transmembrane 2
RREB1 ras responsive element binding protein 1
SAMD4A sterile alpha motif domain containing 4A
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SIRT3 sirtuin 3
SKAP1 src kinase associated phosphoprotein 1
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX15 SRY (sex determining region Y)-box 15
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TDRD3 tudor domain containing 3
TFPI2 tissue factor pathway inhibitor 2
THBS3 thrombospondin 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TK2 thymidine kinase 2, mitochondrial
TMC6 transmembrane channel-like 6
TMC7 transmembrane channel-like 7
TOP3B topoisomerase (DNA) III beta
TREX1 three prime repair exonuclease 1
TTC38 tetratricopeptide repeat domain 38
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR25 WD repeat domain 25
ZBED1 zinc finger, BED-type containing 1
ZC3H7B zinc finger CCCH-type containing 7B
ZNF428 zinc finger protein 428
ZNF75D zinc finger protein 75D
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA2P3 annexin A2 pseudogene 3
ARF5 ADP-ribosylation factor 5
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATAD3A ATPase family, AAA domain containing 3A
BAGE B melanoma antigen
BCL9 B-cell CLL/lymphoma 9
BRAF B-Raf proto-oncogene, serine/threonine kinase
C1ORF115 chromosome 1 open reading frame 115
C1ORF159 chromosome 1 open reading frame 159
C9ORF40 chromosome 9 open reading frame 40
CASZ1 castor zinc finger 1
CCDC88C coiled-coil domain containing 88C
CDK3 cyclin-dependent kinase 3
CHKB choline kinase beta
CIDEC cell death-inducing DFFA-like effector c
CLSPN claspin
DEAF1 DEAF1 transcription factor
DGKD diacylglycerol kinase, delta 130kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EDAR ectodysplasin A receptor
ELMO3 engulfment and cell motility 3
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM114A2 family with sequence similarity 114, member A2
FAM222B family with sequence similarity 222, member B
FANCC Fanconi anemia, complementation group C
FBXO31 F-box protein 31
FEM1C fem-1 homolog c (C. elegans)
FKBP5 FK506 binding protein 5
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GLCE glucuronic acid epimerase
GLI3 GLI family zinc finger 3
HIST2H2AA3 histone cluster 2, H2aa3
HPN hepsin
HTRA1 HtrA serine peptidase 1
KDM7A lysine (K)-specific demethylase 7A
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LHX1 LIM homeobox 1
LIG4 ligase IV, DNA, ATP-dependent
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LTBP2 latent transforming growth factor beta binding protein 2
MAPK12 mitogen-activated protein kinase 12
MBNL3 muscleblind-like splicing regulator 3
N4BP3 NEDD4 binding protein 3
NDE1 nudE neurodevelopment protein 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NRGN neurogranin (protein kinase C substrate, RC3)
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
ODF2 outer dense fiber of sperm tails 2
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDLIM2 PDZ and LIM domain 2 (mystique)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRICKLE3 prickle homolog 3 (Drosophila)
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTPRU protein tyrosine phosphatase, receptor type, U
RECQL4 RecQ protein-like 4
RGS17 regulator of G-protein signaling 17
RIPK4 receptor-interacting serine-threonine kinase 4
RNF170 ring finger protein 170
RNF25 ring finger protein 25
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SETD1A SET domain containing 1A
SETD8 SET domain containing (lysine methyltransferase) 8
SLC35F5 solute carrier family 35, member F5
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMA4 glucuronidase, beta pseudogene
SPINK4 serine peptidase inhibitor, Kazal type 4
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TEAD3 TEA domain family member 3
TEX264 testis expressed 264
TMEM254 transmembrane protein 254
TMPRSS4 transmembrane protease, serine 4
TMSB15A thymosin beta 15a
TPCN1 two pore segment channel 1
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TTC30A tetratricopeptide repeat domain 30A
TWF2 twinfilin actin binding protein 2
USB1 U6 snRNA biogenesis 1
VAV1 vav 1 guanine nucleotide exchange factor
VEGFC vascular endothelial growth factor C
ZBED8 zinc finger, BED-type containing 8
ZNF219 zinc finger protein 219
ZNF23 zinc finger protein 23
ZNF276 zinc finger protein 276
ZNF510 zinc finger protein 510
ZNF668 zinc finger protein 668