aminoglutethimide-2390 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the aminoglutethimide-2390 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALK anaplastic lymphoma receptor tyrosine kinase
ALOX5 arachidonate 5-lipoxygenase
AMDHD2 amidohydrolase domain containing 2
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ATF7 activating transcription factor 7
AURKA aurora kinase A
BICD1 bicaudal D homolog 1 (Drosophila)
BLVRA biliverdin reductase A
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C18ORF25 chromosome 18 open reading frame 25
C1QL1 complement component 1, q subcomponent-like 1
C7ORF69 chromosome 7 open reading frame 69
CAV1 caveolin 1, caveolae protein, 22kDa
CCDC170 coiled-coil domain containing 170
CCR4 chemokine (C-C motif) receptor 4
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDO1 cysteine dioxygenase type 1
CES3 carboxylesterase 3
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRTC1 CREB regulated transcription coactivator 1
CXCL6 chemokine (C-X-C motif) ligand 6
CYB561 cytochrome b561
DDR1 discoidin domain receptor tyrosine kinase 1
DNPEP aspartyl aminopeptidase
DRAM1 DNA-damage regulated autophagy modulator 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EIF5A2 eukaryotic translation initiation factor 5A2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPN2 epsin 2
EXPH5 exophilin 5
F12 coagulation factor XII (Hageman factor)
FAM105A family with sequence similarity 105, member A
FBXO22 F-box protein 22
FCAR Fc fragment of IgA receptor
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FRMD1 FERM domain containing 1
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GOSR2 golgi SNAP receptor complex member 2
GPR161 G protein-coupled receptor 161
GRM7 glutamate receptor, metabotropic 7
HIST1H2BH histone cluster 1, H2bh
HMOX2 heme oxygenase 2
HOMER3 homer scaffolding protein 3
HOXD9 homeobox D9
ICA1 islet cell autoantigen 1, 69kDa
INTS3 integrator complex subunit 3
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit)
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KHSRP KH-type splicing regulatory protein
KIF13B kinesin family member 13B
KLHL22 kelch-like family member 22
KMT2A lysine (K)-specific methyltransferase 2A
LATS1 large tumor suppressor kinase 1
LOC100286895 cell division cycle 27 homolog pseudogene
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MCOLN1 mucolipin 1
MCPH1 microcephalin 1
NDE1 nudE neurodevelopment protein 1
NPY5R neuropeptide Y receptor Y5
PARD6A par-6 family cell polarity regulator alpha
PARP3 poly (ADP-ribose) polymerase family, member 3
PCBP4 poly(rC) binding protein 4
PCGF3 polycomb group ring finger 3
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM2 PDZ and LIM domain 2 (mystique)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIDD1 p53-induced death domain protein 1
PLCH1 phospholipase C, eta 1
POU2F2 POU class 2 homeobox 2
PTAFR platelet-activating factor receptor
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP17 RAN binding protein 17
RGS5 regulator of G-protein signaling 5
RHBDD3 rhomboid domain containing 3
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RPL13P5 ribosomal protein L13 pseudogene 5
SAMD4A sterile alpha motif domain containing 4A
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
TAS2R4 taste receptor, type 2, member 4
TAS2R9 taste receptor, type 2, member 9
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TECPR2 tectonin beta-propeller repeat containing 2
TEX15 testis expressed 15
THAP3 THAP domain containing, apoptosis associated protein 3
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TROVE2 TROVE domain family, member 2
TSC22D4 TSC22 domain family, member 4
TTC30A tetratricopeptide repeat domain 30A
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VCX2 variable charge, X-linked 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YLPM1 YLP motif containing 1

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACP6 acid phosphatase 6, lysophosphatidic
ACYP1 acylphosphatase 1, erythrocyte (common) type
AHCTF1 AT hook containing transcription factor 1
AKTIP AKT interacting protein
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMT aminomethyltransferase
AOAH acyloxyacyl hydrolase (neutrophil)
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHD1 bromo adjacent homology domain containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BIK BCL2-interacting killer (apoptosis-inducing)
C1ORF95 chromosome 1 open reading frame 95
CA11 carbonic anhydrase XI
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC71 coiled-coil domain containing 71
CCNT1 cyclin T1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD34 CD34 molecule
CD70 CD70 molecule
CD82 CD82 molecule
CDA cytidine deaminase
CDR2L cerebellar degeneration-related protein 2-like
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
COLEC10 collectin sub-family member 10 (C-type lectin)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTNNBIP1 catenin, beta interacting protein 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK2 dickkopf WNT signaling pathway inhibitor 2
DOC2A double C2-like domains, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM114A1 family with sequence similarity 114, member A1
FAM184A family with sequence similarity 184, member A
FAM222B family with sequence similarity 222, member B
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOXN2 forkhead box N2
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIP2 glutamate receptor interacting protein 2
GRPR gastrin-releasing peptide receptor
HAMP hepcidin antimicrobial peptide
HIRA histone cell cycle regulator
IPO8 importin 8
ITPKB inositol-trisphosphate 3-kinase B
JUNB jun B proto-oncogene
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA0753 KIAA0753
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LMBR1L limb development membrane protein 1-like
LRP2 low density lipoprotein receptor-related protein 2
MAGEF1 melanoma antigen family F1
MAN2B2 mannosidase, alpha, class 2B, member 2
METTL16 methyltransferase like 16
NCS1 neuronal calcium sensor 1
NT5DC3 5'-nucleotidase domain containing 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PDZD7 PDZ domain containing 7
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRKG2 protein kinase, cGMP-dependent, type II
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RHOBTB1 Rho-related BTB domain containing 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SLC22A14 solute carrier family 22, member 14
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SMA4 glucuronidase, beta pseudogene
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SNX16 sorting nexin 16
SPATS2 spermatogenesis associated, serine-rich 2
SPIN1 spindlin 1
TET3 tet methylcytosine dioxygenase 3
TKFC triokinase/FMN cyclase
TMEM53 transmembrane protein 53
TMUB2 transmembrane and ubiquitin-like domain containing 2
TOR4A torsin family 4, member A
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TXNL4B thioredoxin-like 4B
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VNN2 vanin 2
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WASF3 WAS protein family, member 3
ZBTB40 zinc finger and BTB domain containing 40
ZC4H2 zinc finger, C4H2 domain containing
ZDHHC14 zinc finger, DHHC-type containing 14
ZHX2 zinc fingers and homeoboxes 2
ZNF175 zinc finger protein 175
ZNF32 zinc finger protein 32
ZNF443 zinc finger protein 443
ZNF506 zinc finger protein 506
ZNF747 zinc finger protein 747
ZNF862 zinc finger protein 862