aminoacyl-trna synthetase multienzyme complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. (Gene Ontology, GO_0017101)
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39 proteins co-occuring with the aminoacyl-trna synthetase multienzyme complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
EPRS glutamyl-prolyl-tRNA synthetase 2.22316
KARS lysyl-tRNA synthetase 1.89731
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 1.88763
RARS arginyl-tRNA synthetase 1.85388
MARS methionyl-tRNA synthetase 1.8525
RARS2 arginyl-tRNA synthetase 2, mitochondrial 1.83474
AARS alanyl-tRNA synthetase 1.76432
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 1.73184
DARS aspartyl-tRNA synthetase 1.64075
MARS2 methionyl-tRNA synthetase 2, mitochondrial 1.61119
QARS glutaminyl-tRNA synthetase 1.46495
EARS2 glutamyl-tRNA synthetase 2, mitochondrial 1.42092
TARSL2 threonyl-tRNA synthetase-like 2 1.34283
LARS leucyl-tRNA synthetase 1.30175
IARS isoleucyl-tRNA synthetase 1.28997
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 1.27505
RPL13A ribosomal protein L13a 0.912977
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 0.872266
HINT1 histidine triad nucleotide binding protein 1 0.595593
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.586361
MRPL13 mitochondrial ribosomal protein L13 0.576329
EML1 echinoderm microtubule associated protein like 1 0.548535
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.516124
VARS valyl-tRNA synthetase 0.498636
MITF microphthalmia-associated transcription factor 0.4958
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.472412
SNCAIP synuclein, alpha interacting protein 0.460401
EEF1A1P6 eukaryotic translation elongation factor 1 alpha 1 pseudogene 6 0.45004
SLURP1 secreted LY6/PLAUR domain containing 1 0.416511
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.41143
RPL5 ribosomal protein L5 0.398199
CP ceruloplasmin (ferroxidase) 0.342285
WARS tryptophanyl-tRNA synthetase 0.333225
USF2 upstream transcription factor 2, c-fos interacting 0.330213
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.309986
CARS cysteinyl-tRNA synthetase 0.266042
UBE2K ubiquitin-conjugating enzyme E2K 0.172468
UBE2S ubiquitin-conjugating enzyme E2S 0.159074
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.157397