amiloride-4109 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the amiloride-4109 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
ACPP acid phosphatase, prostate
ACTN2 actinin, alpha 2
ADAM20 ADAM metallopeptidase domain 20
AICDA activation-induced cytidine deaminase
AIRE autoimmune regulator
AKR1C4 aldo-keto reductase family 1, member C4
ANKRD7 ankyrin repeat domain 7
ATF7IP activating transcription factor 7 interacting protein
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATP9B ATPase, class II, type 9B
BAZ1B bromodomain adjacent to zinc finger domain, 1B
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCDC64 coiled-coil domain containing 64
CCKBR cholecystokinin B receptor
CD200 CD200 molecule
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
CNPY4 canopy FGF signaling regulator 4
CTSF cathepsin F
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DCN decorin
DOCK9 dedicator of cytokinesis 9
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ETV7 ets variant 7
FAM171A1 family with sequence similarity 171, member A1
FASLG Fas ligand (TNF superfamily, member 6)
FMO6P flavin containing monooxygenase 6 pseudogene
GAB1 GRB2-associated binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GJA9 gap junction protein, alpha 9, 59kDa
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRM7 glutamate receptor, metabotropic 7
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HOXD9 homeobox D9
IL12B interleukin 12B
INHBA inhibin, beta A
KERA keratocan
KLHL25 kelch-like family member 25
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LCMT2 leucine carboxyl methyltransferase 2
LDB3 LIM domain binding 3
LIMD1 LIM domains containing 1
LPL lipoprotein lipase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAL mal, T-cell differentiation protein
MAST3 microtubule associated serine/threonine kinase 3
MT4 metallothionein 4
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MXD4 MAX dimerization protein 4
MYO15B myosin XVB
N4BP2L1 NEDD4 binding protein 2-like 1
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCKIPSD NCK interacting protein with SH3 domain
NR2E3 nuclear receptor subfamily 2, group E, member 3
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRN1 neuritin 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PER1 period circadian clock 1
PLCL2 phospholipase C-like 2
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRDM1 PR domain containing 1, with ZNF domain
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RASAL2 RAS protein activator like 2
RERE arginine-glutamic acid dipeptide (RE) repeats
RPL35A ribosomal protein L35a
RPS4Y1 ribosomal protein S4, Y-linked 1
RS1 retinoschisin 1
SIRT5 sirtuin 5
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC35E1 solute carrier family 35, member E1
SLC43A3 solute carrier family 43, member 3
SOX12 SRY (sex determining region Y)-box 12
SPINK5 serine peptidase inhibitor, Kazal type 5
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SSPN sarcospan
SSX3 synovial sarcoma, X breakpoint 3
SUGP1 SURP and G patch domain containing 1
SYNDIG1 synapse differentiation inducing 1
SYNE1 spectrin repeat containing, nuclear envelope 1
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TAOK2 TAO kinase 2
TMOD1 tropomodulin 1
TREX1 three prime repair exonuclease 1
UBXN1 UBX domain protein 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VCL vinculin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEZT vezatin, adherens junctions transmembrane protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WSCD1 WSC domain containing 1
ZBTB43 zinc finger and BTB domain containing 43
ZNF224 zinc finger protein 224
ZNF407 zinc finger protein 407

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADAM9 ADAM metallopeptidase domain 9
AIDA axin interactor, dorsalization associated
ALS2CL ALS2 C-terminal like
APLP1 amyloid beta (A4) precursor-like protein 1
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ATAD5 ATPase family, AAA domain containing 5
BEX4 brain expressed, X-linked 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C7ORF43 chromosome 7 open reading frame 43
CBX8 chromobox homolog 8
CCDC121 coiled-coil domain containing 121
CDC37 cell division cycle 37
CENPO centromere protein O
CFAP69 cilia and flagella associated protein 69
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase
CNR2 cannabinoid receptor 2 (macrophage)
COMMD10 COMM domain containing 10
CRYBB2P1 crystallin, beta B2 pseudogene 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTNNBL1 catenin, beta like 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DGKE diacylglycerol kinase, epsilon 64kDa
DNAL4 dynein, axonemal, light chain 4
EAF2 ELL associated factor 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERCC4 excision repair cross-complementation group 4
ESRP2 epithelial splicing regulatory protein 2
FAM46C family with sequence similarity 46, member C
FBXO31 F-box protein 31
FGF13 fibroblast growth factor 13
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRMD1 FERM domain containing 1
FRS2 fibroblast growth factor receptor substrate 2
GPR19 G protein-coupled receptor 19
GTF2I general transcription factor IIi
HDAC11 histone deacetylase 11
HIST1H2AJ histone cluster 1, H2aj
HIST1H3E histone cluster 1, H3e
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IGSF1 immunoglobulin superfamily, member 1
IPO13 importin 13
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCTD20 potassium channel tetramerization domain containing 20
KIAA0232 KIAA0232
KIAA0895 KIAA0895
KIF18A kinesin family member 18A
LRRC61 leucine rich repeat containing 61
MATK megakaryocyte-associated tyrosine kinase
MFSD12 major facilitator superfamily domain containing 12
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MVD mevalonate (diphospho) decarboxylase
NRSN2 neurensin 2
ODC1 ornithine decarboxylase 1
ODF2 outer dense fiber of sperm tails 2
PARPBP PARP1 binding protein
PBX3 pre-B-cell leukemia homeobox 3
PCDHB8 protocadherin beta 8
PCSK7 proprotein convertase subtilisin/kexin type 7
PGPEP1 pyroglutamyl-peptidase I
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
POLL polymerase (DNA directed), lambda
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
PTPN14 protein tyrosine phosphatase, non-receptor type 14
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB30 RAB30, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RFXANK regulatory factor X-associated ankyrin-containing protein
RNF122 ring finger protein 122
RNMTL1 RNA methyltransferase like 1
ROM1 retinal outer segment membrane protein 1
RPL10L ribosomal protein L10-like
RRAGB Ras-related GTP binding B
SCD5 stearoyl-CoA desaturase 5
SETD8 SET domain containing (lysine methyltransferase) 8
SETMAR SET domain and mariner transposase fusion gene
SLC25A40 solute carrier family 25, member 40
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLMO1 slowmo homolog 1 (Drosophila)
SND1-IT1 SND1 intronic transcript 1
SPIDR scaffolding protein involved in DNA repair
STK16 serine/threonine kinase 16
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
THBS3 thrombospondin 3
TICAM1 toll-like receptor adaptor molecule 1
TLR5 toll-like receptor 5
TMEM51 transmembrane protein 51
TMEM57 transmembrane protein 57
TNS2 tensin 2
TRABD TraB domain containing
TRIM32 tripartite motif containing 32
USB1 U6 snRNA biogenesis 1
VIM vimentin
VWA1 von Willebrand factor A domain containing 1
ZNF227 zinc finger protein 227