ambroxol-6719 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the ambroxol-6719 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANKLE2 ankyrin repeat and LEM domain containing 2
ANKRD12 ankyrin repeat domain 12
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
CDC14B cell division cycle 14B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEP290 centrosomal protein 290kDa
CFH complement factor H
CHRM5 cholinergic receptor, muscarinic 5
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CISH cytokine inducible SH2-containing protein
CTSF cathepsin F
DHRS9 dehydrogenase/reductase (SDR family) member 9
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF5B eukaryotic translation initiation factor 5B
EPB41L1 erythrocyte membrane protein band 4.1-like 1
ERAP1 endoplasmic reticulum aminopeptidase 1
EZR ezrin
FAM63A family with sequence similarity 63, member A
FBXO11 F-box protein 11
FLJ11292
GAN gigaxonin
GUK1 guanylate kinase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
H2AFX H2A histone family, member X
HAUS6 HAUS augmin-like complex, subunit 6
HEMK1 HemK methyltransferase family member 1
HIF3A hypoxia inducible factor 3, alpha subunit
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IER3IP1 immediate early response 3 interacting protein 1
IFT74 intraflagellar transport 74
IL12B interleukin 12B
IL20RA interleukin 20 receptor, alpha
IL6 interleukin 6
INADL InaD-like (Drosophila)
ITGB5 integrin, beta 5
ITM2B integral membrane protein 2B
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KRT7 keratin 7, type II
LARGE like-glycosyltransferase
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00652 long intergenic non-protein coding RNA 652
LIPG lipase, endothelial
MAK male germ cell-associated kinase
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP3 matrix metallopeptidase 3
MRPL52 mitochondrial ribosomal protein L52
MTAP methylthioadenosine phosphorylase
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OAZ3 ornithine decarboxylase antizyme 3
PAX2 paired box 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDS5A PDS5 cohesin associated factor A
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PRKG1 protein kinase, cGMP-dependent, type I
PRRC2C proline-rich coiled-coil 2C
PRUNE2 prune homolog 2 (Drosophila)
PURA purine-rich element binding protein A
RPL10 ribosomal protein L10
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SERINC5 serine incorporator 5
SH3BP2 SH3-domain binding protein 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SOAT1 sterol O-acyltransferase 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN5 spectrin, beta, non-erythrocytic 5
STK17A serine/threonine kinase 17a
TFG TRK-fused gene
TGFB2 transforming growth factor, beta 2
TPI1 triosephosphate isomerase 1
TTC12 tetratricopeptide repeat domain 12
TTF2 transcription termination factor, RNA polymerase II
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBE2I ubiquitin-conjugating enzyme E2I
WBP4 WW domain binding protein 4
ZFP30 ZFP30 zinc finger protein
ZNF214 zinc finger protein 214
ZNF268 zinc finger protein 268
ZNF528 zinc finger protein 528
ZNF623 zinc finger protein 623
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ADAT1 adenosine deaminase, tRNA-specific 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ANXA2P3 annexin A2 pseudogene 3
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AXIN1 axin 1
BAK1 BCL2-antagonist/killer 1
BGLAP bone gamma-carboxyglutamate (gla) protein
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CDCA3 cell division cycle associated 3
CGREF1 cell growth regulator with EF-hand domain 1
CLDN4 claudin 4
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
DDA1 DET1 and DDB1 associated 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ERCC2 excision repair cross-complementation group 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
GCHFR GTP cyclohydrolase I feedback regulator
GLT8D2 glycosyltransferase 8 domain containing 2
GNL1 guanine nucleotide binding protein-like 1
H2BFS H2B histone family, member S (pseudogene)
HHLA3 HERV-H LTR-associating 3
HJURP Holliday junction recognition protein
HP1BP3 heterochromatin protein 1, binding protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IFI35 interferon-induced protein 35
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IPO8 importin 8
ISYNA1 inositol-3-phosphate synthase 1
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
KLF13 Kruppel-like factor 13
LRRC61 leucine rich repeat containing 61
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAPKAP1 mitogen-activated protein kinase associated protein 1
MCOLN1 mucolipin 1
MLF2 myeloid leukemia factor 2
MPDU1 mannose-P-dolichol utilization defect 1
MRPL23 mitochondrial ribosomal protein L23
MT1HL1 metallothionein 1H-like 1
MT2A metallothionein 2A
MXD3 MAX dimerization protein 3
MYL9 myosin, light chain 9, regulatory
NABP2 nucleic acid binding protein 2
NDE1 nudE neurodevelopment protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
NRSN2 neurensin 2
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
ODF2 outer dense fiber of sperm tails 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PFN1 profilin 1
PGD phosphogluconate dehydrogenase
PKM pyruvate kinase, muscle
PKN1 protein kinase N1
PLD3 phospholipase D family, member 3
POLM polymerase (DNA directed), mu
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PTK7 protein tyrosine kinase 7 (inactive)
RABAC1 Rab acceptor 1 (prenylated)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RPL11 ribosomal protein L11
RPP25 ribonuclease P/MRP 25kDa subunit
S100A3 S100 calcium binding protein A3
S100A4 S100 calcium binding protein A4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SF3B5 splicing factor 3b, subunit 5, 10kDa
SLPI secretory leukocyte peptidase inhibitor
SPTBN2 spectrin, beta, non-erythrocytic 2
TBC1D17 TBC1 domain family, member 17
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF2 transmembrane 7 superfamily member 2
TRAPPC2L trafficking protein particle complex 2-like
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPAN1 tetraspanin 1
UNC119 unc-119 homolog (C. elegans)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WBP2 WW domain binding protein 2
WDR37 WD repeat domain 37
ZNF692 zinc finger protein 692
ZNHIT1 zinc finger, HIT-type containing 1