ambroxol-3238 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the ambroxol-3238 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADGRG1 adhesion G protein-coupled receptor G1
AHNAK AHNAK nucleoprotein
AKAP1 A kinase (PRKA) anchor protein 1
ANKRD12 ankyrin repeat domain 12
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
APC adenomatous polyposis coli
ARHGAP26 Rho GTPase activating protein 26
ARL3 ADP-ribosylation factor-like 3
ART3 ADP-ribosyltransferase 3
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
ATXN2L ataxin 2-like
BAG4 BCL2-associated athanogene 4
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2L10 BCL2-like 10 (apoptosis facilitator)
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C2ORF27A chromosome 2 open reading frame 27A
CA4 carbonic anhydrase IV
CCDC57 coiled-coil domain containing 57
CD177 CD177 molecule
CDK19 cyclin-dependent kinase 19
CHML choroideremia-like (Rab escort protein 2)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CYB5A cytochrome b5 type A (microsomal)
DOCK6 dedicator of cytokinesis 6
EHD1 EH-domain containing 1
EPHB2 EPH receptor B2
EVA1B eva-1 homolog B (C. elegans)
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit
FABP3 fatty acid binding protein 3, muscle and heart
FCMR Fc fragment of IgM receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FRMD4B FERM domain containing 4B
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GK3P glycerol kinase 3 pseudogene
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR135 G protein-coupled receptor 135
GYPB glycophorin B (MNS blood group)
HBS1L HBS1-like translational GTPase
HCRTR2 hypocretin (orexin) receptor 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
IFNA2 interferon, alpha 2
IL22 interleukin 22
IRS2 insulin receptor substrate 2
ITGA7 integrin, alpha 7
ITGA8 integrin, alpha 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JMJD6 jumonji domain containing 6
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KRT83 keratin 83, type II
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LCT lactase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK7 mitogen-activated protein kinase 7
MBD2 methyl-CpG binding domain protein 2
METTL7A methyltransferase like 7A
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MR1 major histocompatibility complex, class I-related
MRPL41 mitochondrial ribosomal protein L41
MTCP1 mature T-cell proliferation 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH14 myosin, heavy chain 14, non-muscle
MYOZ1 myozenin 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PHF7 PHD finger protein 7
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PROL1 proline rich, lacrimal 1
PTCRA pre T-cell antigen receptor alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVRL3 poliovirus receptor-related 3
RAB3A RAB3A, member RAS oncogene family
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RARG retinoic acid receptor, gamma
RTEL1 regulator of telomere elongation helicase 1
SH3BP2 SH3-domain binding protein 2
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHOX2 short stature homeobox 2
SLC16A4 solute carrier family 16, member 4
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPRR2B small proline-rich protein 2B
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
TAPBP TAP binding protein (tapasin)
TGFB2 transforming growth factor, beta 2
TLK1 tousled-like kinase 1
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNS1 tensin 1
TPMT thiopurine S-methyltransferase
TRIM29 tripartite motif containing 29
TTC38 tetratricopeptide repeat domain 38
VCAN versican
ZFP36L1 ZFP36 ring finger protein-like 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF37BP zinc finger protein 37B, pseudogene
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABHD17B abhydrolase domain containing 17B
ACAD10 acyl-CoA dehydrogenase family, member 10
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ANXA2P3 annexin A2 pseudogene 3
AQP7 aquaporin 7
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATF3 activating transcription factor 3
BAHCC1 BAH domain and coiled-coil containing 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C14ORF105 chromosome 14 open reading frame 105
C14ORF79 chromosome 14 open reading frame 79
C1ORF54 chromosome 1 open reading frame 54
CD3D CD3d molecule, delta (CD3-TCR complex)
CD79B CD79b molecule, immunoglobulin-associated beta
CDK20 cyclin-dependent kinase 20
CES1 carboxylesterase 1
CFAP69 cilia and flagella associated protein 69
CNR2 cannabinoid receptor 2 (macrophage)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRABP1 cellular retinoic acid binding protein 1
CRY2 cryptochrome circadian clock 2
CRYGC crystallin, gamma C
CSF1R colony stimulating factor 1 receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DGAT1 diacylglycerol O-acyltransferase 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DPYS dihydropyrimidinase
DSE dermatan sulfate epimerase
EGFL7 EGF-like-domain, multiple 7
ERN2 endoplasmic reticulum to nucleus signaling 2
FAAH fatty acid amide hydrolase
FAM169A family with sequence similarity 169, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FILIP1L filamin A interacting protein 1-like
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GBP2 guanylate binding protein 2, interferon-inducible
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HOXD11 homeobox D11
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
INCENP inner centromere protein antigens 135/155kDa
IRF6 interferon regulatory factor 6
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KREMEN2 kringle containing transmembrane protein 2
LOC100286895 cell division cycle 27 homolog pseudogene
LRRTM2 leucine rich repeat transmembrane neuronal 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MDM4 MDM4, p53 regulator
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPFFR1 neuropeptide FF receptor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
ONECUT2 one cut homeobox 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB3 protocadherin beta 3
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PODNL1 podocan-like 1
PTK6 protein tyrosine kinase 6
PTPRU protein tyrosine phosphatase, receptor type, U
RAD54L2 RAD54-like 2 (S. cerevisiae)
RARS arginyl-tRNA synthetase
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELN reelin
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF122 ring finger protein 122
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SAYSD1 SAYSVFN motif domain containing 1
SERGEF secretion regulating guanine nucleotide exchange factor
SH2B3 SH2B adaptor protein 3
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPRY2 sprouty homolog 2 (Drosophila)
STAB2 stabilin 2
STEAP3 STEAP family member 3, metalloreductase
TCTN1 tectonic family member 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TIGD6 tigger transposable element derived 6
TMC7 transmembrane channel-like 7
TMEM212 transmembrane protein 212
TUBA3C tubulin, alpha 3c
USP36 ubiquitin specific peptidase 36
VGF VGF nerve growth factor inducible
ZNF211 zinc finger protein 211
ZNF227 zinc finger protein 227
ZNF510 zinc finger protein 510