amantadine-4222 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the amantadine-4222 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADAM3A ADAM metallopeptidase domain 3A (pseudogene)
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
AFF2 AF4/FMR2 family, member 2
AGXT alanine-glyoxylate aminotransferase
AIM2 absent in melanoma 2
ANGPT4 angiopoietin 4
APOA1 apolipoprotein A-I
ARHGAP35 Rho GTPase activating protein 35
ARSD arylsulfatase D
ASMT acetylserotonin O-methyltransferase
ATP9B ATPase, class II, type 9B
C19ORF26 chromosome 19 open reading frame 26
C2ORF54 chromosome 2 open reading frame 54
CALML3 calmodulin-like 3
CCL21 chemokine (C-C motif) ligand 21
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLEC10A C-type lectin domain family 10, member A
CSF1 colony stimulating factor 1 (macrophage)
CSN2 casein beta
CXXC4 CXXC finger protein 4
DACH1 dachshund family transcription factor 1
DAPK2 death-associated protein kinase 2
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DNALI1 dynein, axonemal, light intermediate chain 1
DOC2B double C2-like domains, beta
DOK4 docking protein 4
EDN3 endothelin 3
EFS embryonal Fyn-associated substrate
EGOT eosinophil granule ontogeny transcript (non-protein coding)
ESPN espin
FAM66D family with sequence similarity 66, member D
FUBP1 far upstream element (FUSE) binding protein 1
FZD10 frizzled class receptor 10
GLRA2 glycine receptor, alpha 2
GPR37L1 G protein-coupled receptor 37 like 1
HAO2 hydroxyacid oxidase 2 (long chain)
HIST1H2AL histone cluster 1, H2al
HLA-DOA major histocompatibility complex, class II, DO alpha
HOXB3 homeobox B3
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL37 interleukin 37
IL5RA interleukin 5 receptor, alpha
INADL InaD-like (Drosophila)
INS insulin
IZUMO4 IZUMO family member 4
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KIAA1109 KIAA1109
KIF25-AS1 KIF25 antisense RNA 1
KLK13 kallikrein-related peptidase 13
LARGE like-glycosyltransferase
LUM lumican
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MC3R melanocortin 3 receptor
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NRXN2 neurexin 2
OGFR opioid growth factor receptor
PAPOLB poly(A) polymerase beta (testis specific)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POU6F1 POU class 6 homeobox 1
PPARD peroxisome proliferator-activated receptor delta
PRB4 proline-rich protein BstNI subfamily 4
PTGDR2 prostaglandin D2 receptor 2
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTTG2 pituitary tumor-transforming 2
RARA retinoic acid receptor, alpha
REC8 REC8 meiotic recombination protein
REG1A regenerating islet-derived 1 alpha
RSU1 Ras suppressor protein 1
SCGB2A1 secretoglobin, family 2A, member 1
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SOX5 SRY (sex determining region Y)-box 5
SP110 SP110 nuclear body protein
SPAG11A sperm associated antigen 11A
SRPX2 sushi-repeat containing protein, X-linked 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBXAS1 thromboxane A synthase 1 (platelet)
THEMIS2 thymocyte selection associated family member 2
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1
TSSK2 testis-specific serine kinase 2
UBASH3A ubiquitin associated and SH3 domain containing A
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
AATK apoptosis-associated tyrosine kinase
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
AGBL3 ATP/GTP binding protein-like 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANOS1 anosmin 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APOC4 apolipoprotein C-IV
ARRB2 arrestin, beta 2
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP13A2 ATPase type 13A2
BATF3 basic leucine zipper transcription factor, ATF-like 3
BEX1 brain expressed, X-linked 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BTF3P11 basic transcription factor 3 pseudogene 11
C10ORF88 chromosome 10 open reading frame 88
C1ORF105 chromosome 1 open reading frame 105
C22ORF29 chromosome 22 open reading frame 29
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CEP131 centrosomal protein 131kDa
CES1 carboxylesterase 1
CFAP69 cilia and flagella associated protein 69
CHMP6 charged multivesicular body protein 6
CLDN11 claudin 11
CPED1 cadherin-like and PC-esterase domain containing 1
CSF1R colony stimulating factor 1 receptor
CSRNP3 cysteine-serine-rich nuclear protein 3
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
ERF Ets2 repressor factor
ETNK2 ethanolamine kinase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXL7 F-box and leucine-rich repeat protein 7
FOXC1 forkhead box C1
GMEB1 glucocorticoid modulatory element binding protein 1
GMPR guanosine monophosphate reductase
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK1 hook microtubule-tethering protein 1
HSPA1L heat shock 70kDa protein 1-like
IFNA17 interferon, alpha 17
IL11RA interleukin 11 receptor, alpha
IL17RA interleukin 17 receptor A
IL17RB interleukin 17 receptor B
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0894 KIAA0894 protein
KLF3 Kruppel-like factor 3 (basic)
KRT34 keratin 34, type I
KRT8P12 keratin 8 pseudogene 12
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00597 long intergenic non-protein coding RNA 597
LMO2 LIM domain only 2 (rhombotin-like 1)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPPR4 lipid phosphate phosphatase-related protein type 4
LTC4S leukotriene C4 synthase
LY86 lymphocyte antigen 86
MN1 meningioma (disrupted in balanced translocation) 1
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
NDP Norrie disease (pseudoglioma)
NMB neuromedin B
NR1H3 nuclear receptor subfamily 1, group H, member 3
PADI1 peptidyl arginine deiminase, type I
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PALMD palmdelphin
PAQR6 progestin and adipoQ receptor family member VI
PDE8B phosphodiesterase 8B
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRDM14 PR domain containing 14
PRF1 perforin 1 (pore forming protein)
PSKH1 protein serine kinase H1
R3HCC1L R3H domain and coiled-coil containing 1-like
S1PR1 sphingosine-1-phosphate receptor 1
SALL2 spalt-like transcription factor 2
SLN sarcolipin
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SPRYD7 SPRY domain containing 7
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TDRD1 tudor domain containing 1
TEX40 testis expressed 40
THBS3 thrombospondin 3
THRAP3 thyroid hormone receptor associated protein 3
TMEM40 transmembrane protein 40
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VASH1 vasohibin 1
VGLL3 vestigial-like family member 3
ZNF254 zinc finger protein 254
ZNF492 zinc finger protein 492
ZNF749 zinc finger protein 749
ZNF778 zinc finger protein 778