alvespimycin-993 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the alvespimycin-993 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABHD4 abhydrolase domain containing 4
ACVR1B activin A receptor, type IB
ADCY7 adenylate cyclase 7
ADM adrenomedullin
AFF2 AF4/FMR2 family, member 2
AGFG1 ArfGAP with FG repeats 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP1 aquaporin 1 (Colton blood group)
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BIN1 bridging integrator 1
BMP5 bone morphogenetic protein 5
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CASP1 caspase 1, apoptosis-related cysteine peptidase
CFLAR CASP8 and FADD-like apoptosis regulator
CLCN5 chloride channel, voltage-sensitive 5
CSRP2 cysteine and glycine-rich protein 2
CXORF21 chromosome X open reading frame 21
DBF4B DBF4 zinc finger B
DICER1 dicer 1, ribonuclease type III
DNAH3 dynein, axonemal, heavy chain 3
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ELSPBP1 epididymal sperm binding protein 1
EPHB2 EPH receptor B2
FAM46C family with sequence similarity 46, member C
FLT1 fms-related tyrosine kinase 1
FOXG1 forkhead box G1
GLS glutaminase
GPX2 glutathione peroxidase 2
GRIK5 glutamate receptor, ionotropic, kainate 5
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HFE hemochromatosis
HLA-DRB6 major histocompatibility complex, class II, DR beta 6 (pseudogene)
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IFT27 intraflagellar transport 27
LYPD1 LY6/PLAUR domain containing 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTMR8 myotubularin related protein 8
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NDRG1 N-myc downstream regulated 1
NMT2 N-myristoyltransferase 2
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE12 phosphodiesterase 12
PGF placental growth factor
PHOX2B paired-like homeobox 2b
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKNOX1 PBX/knotted 1 homeobox 1
PKP1 plakophilin 1
PLK4 polo-like kinase 4
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PRLR prolactin receptor
PRSS16 protease, serine, 16 (thymus)
RALGDS ral guanine nucleotide dissociation stimulator
RFPL3 ret finger protein-like 3
RGS2 regulator of G-protein signaling 2
RYR1 ryanodine receptor 1 (skeletal)
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAT5A signal transducer and activator of transcription 5A
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TGFA transforming growth factor, alpha
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM53 transmembrane protein 53
TSPYL2 TSPY-like 2
VLDLR very low density lipoprotein receptor
ZC3H7B zinc finger CCCH-type containing 7B
ZNF10 zinc finger protein 10
ZNF16 zinc finger protein 16
ZNF197 zinc finger protein 197
ZNF227 zinc finger protein 227
ZNF329 zinc finger protein 329
ZNF419 zinc finger protein 419
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACYP1 acylphosphatase 1, erythrocyte (common) type
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD36B ankyrin repeat domain 36B
ANP32A-IT1 ANP32A intronic transcript 1
ASTE1 asteroid homolog 1 (Drosophila)
ATAD3A ATPase family, AAA domain containing 3A
BAGE B melanoma antigen
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C10ORF88 chromosome 10 open reading frame 88
C11ORF80 chromosome 11 open reading frame 80
C11ORF95 chromosome 11 open reading frame 95
C9ORF3 chromosome 9 open reading frame 3
CBX4 chromobox homolog 4
CD3EAP CD3e molecule, epsilon associated protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDIT3 DNA-damage-inducible transcript 3
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DSE dermatan sulfate epimerase
EGR3 early growth response 3
EPN3 epsin 3
ETAA1 Ewing tumor-associated antigen 1
FAM118A family with sequence similarity 118, member A
FAM155B family with sequence similarity 155, member B
FAM63A family with sequence similarity 63, member A
FBXL15 F-box and leucine-rich repeat protein 15
FPGS folylpolyglutamate synthase
GPR19 G protein-coupled receptor 19
GUF1 GUF1 GTPase homolog (S. cerevisiae)
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IRX5 iroquois homeobox 5
JUNB jun B proto-oncogene
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDM7A lysine (K)-specific demethylase 7A
KIZ kizuna centrosomal protein
KLF10 Kruppel-like factor 10
KRT8P12 keratin 8 pseudogene 12
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LY6G5C lymphocyte antigen 6 complex, locus G5C
MANSC1 MANSC domain containing 1
MAP3K3 mitogen-activated protein kinase kinase kinase 3
METTL2B methyltransferase like 2B
METTL8 methyltransferase like 8
MTRF1 mitochondrial translational release factor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCS1 neuronal calcium sensor 1
NMU neuromedin U
NUPL2 nucleoporin like 2
PCF11 PCF11 cleavage and polyadenylation factor subunit
PGPEP1 pyroglutamyl-peptidase I
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PNPLA6 patatin-like phospholipase domain containing 6
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCD protein kinase C, delta
PRMT7 protein arginine methyltransferase 7
PUS1 pseudouridylate synthase 1
PYCRL pyrroline-5-carboxylate reductase-like
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RBBP6 retinoblastoma binding protein 6
RBM14 RNA binding motif protein 14
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RIBC2 RIB43A domain with coiled-coils 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCO2 SCO2 cytochrome c oxidase assembly protein
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH2B2 SH2B adaptor protein 2
SHARPIN SHANK-associated RH domain interactor
SLC10A3 solute carrier family 10, member 3
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
SMAD7 SMAD family member 7
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNORA21 small nucleolar RNA, H/ACA box 21
SPATA2L spermatogenesis associated 2-like
SYTL2 synaptotagmin-like 2
TBC1D31 TBC1 domain family, member 31
TFRC transferrin receptor
TJP3 tight junction protein 3
TPCN1 two pore segment channel 1
TRAPPC12 trafficking protein particle complex 12
UBQLN4 ubiquilin 4
ZBED1 zinc finger, BED-type containing 1
ZMAT5 zinc finger, matrin-type 5
ZNF239 zinc finger protein 239