alvespimycin-4437 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the alvespimycin-4437 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ADCY7 adenylate cyclase 7
AKAP9 A kinase (PRKA) anchor protein 9
ANGPT4 angiopoietin 4
APOE apolipoprotein E
ARG2 arginase 2
ARMCX4 armadillo repeat containing, X-linked 4
ARRB1 arrestin, beta 1
ATG10 autophagy related 10
C14ORF1 chromosome 14 open reading frame 1
C22ORF46 chromosome 22 open reading frame 46
CACFD1 calcium channel flower domain containing 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CCND2 cyclin D2
CD300C CD300c molecule
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
COL3A1 collagen, type III, alpha 1
COL4A6 collagen, type IV, alpha 6
CPEB1 cytoplasmic polyadenylation element binding protein 1
CROCC ciliary rootlet coiled-coil, rootletin
DFNB31 deafness, autosomal recessive 31
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
EDN1 endothelin 1
EDRF1 erythroid differentiation regulatory factor 1
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAXDC2 fatty acid hydroxylase domain containing 2
FGF4 fibroblast growth factor 4
FGF6 fibroblast growth factor 6
GABARAPL1 GABA(A) receptor-associated protein like 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GP5 glycoprotein V (platelet)
GP6 glycoprotein VI (platelet)
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HOPX HOP homeobox
HPS1 Hermansky-Pudlak syndrome 1
HRH3 histamine receptor H3
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ICOSLG inducible T-cell co-stimulator ligand
IGSF6 immunoglobulin superfamily, member 6
IL7R interleukin 7 receptor
ITPK1 inositol-tetrakisphosphate 1-kinase
KEL Kell blood group, metallo-endopeptidase
KIF1A kinesin family member 1A
KLK13 kallikrein-related peptidase 13
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LCK LCK proto-oncogene, Src family tyrosine kinase
LOXL2 lysyl oxidase-like 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDFI MyoD family inhibitor
MORN1 MORN repeat containing 1
NF1 neurofibromin 1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
OXCT2 3-oxoacid CoA transferase 2
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDZD2 PDZ domain containing 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PPP1R37 protein phosphatase 1, regulatory subunit 37
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAI2 retinoic acid induced 2
REEP2 receptor accessory protein 2
RFPL2 ret finger protein-like 2
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS12 regulator of G-protein signaling 12
RGS4 regulator of G-protein signaling 4
SCAND2P SCAN domain containing 2 pseudogene
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLAMF7 SLAM family member 7
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SYNPO synaptopodin
TEF thyrotrophic embryonic factor
TGFB2 transforming growth factor, beta 2
TGM2 transglutaminase 2
TSC2 tuberous sclerosis 2
USP22 ubiquitin specific peptidase 22
WDR33 WD repeat domain 33
ZNF384 zinc finger protein 384

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM23 ADAM metallopeptidase domain 23
ADGRB2 adhesion G protein-coupled receptor B2
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
AOC2 amine oxidase, copper containing 2 (retina-specific)
ATAD5 ATPase family, AAA domain containing 5
BAHCC1 BAH domain and coiled-coil containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BMPR1B bone morphogenetic protein receptor, type IB
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C16ORF59 chromosome 16 open reading frame 59
C1ORF105 chromosome 1 open reading frame 105
C1ORF56 chromosome 1 open reading frame 56
C1QTNF3 C1q and tumor necrosis factor related protein 3
C1S complement component 1, s subcomponent
C3 complement component 3
C5ORF45 chromosome 5 open reading frame 45
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNO cyclin O
CDH7 cadherin 7, type 2
CEP295 centrosomal protein 295kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL9A2 collagen, type IX, alpha 2
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CUZD1 CUB and zona pellucida-like domains 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDN dendrin
DLK2 delta-like 2 homolog (Drosophila)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F8 E2F transcription factor 8
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNA3 ephrin-A3
FBRS fibrosin
FBXL15 F-box and leucine-rich repeat protein 15
GJC1 gap junction protein, gamma 1, 45kDa
GLB1L2 galactosidase, beta 1-like 2
GPR3 G protein-coupled receptor 3
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HAS2 hyaluronan synthase 2
HIST1H4C histone cluster 1, H4c
HLA-DMA major histocompatibility complex, class II, DM alpha
HOXA10 homeobox A10
HOXA4 homeobox A4
HOXA7 homeobox A7
HOXC10 homeobox C10
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL6 interleukin 6
INCENP inner centromere protein antigens 135/155kDa
KDM4D lysine (K)-specific demethylase 4D
KIRREL kin of IRRE like (Drosophila)
KLK7 kallikrein-related peptidase 7
MCM10 minichromosome maintenance complex component 10
MMRN2 multimerin 2
MOCS3 molybdenum cofactor synthesis 3
MTCP1 mature T-cell proliferation 1
MUC3A mucin 3A, cell surface associated
NCALD neurocalcin delta
NOL10 nucleolar protein 10
NT5M 5',3'-nucleotidase, mitochondrial
ODF2 outer dense fiber of sperm tails 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAQR6 progestin and adipoQ receptor family member VI
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLA1A phospholipase A1 member A
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRR15L proline rich 15-like
PTPRH protein tyrosine phosphatase, receptor type, H
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF122 ring finger protein 122
SCARA3 scavenger receptor class A, member 3
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SH2D2A SH2 domain containing 2A
SLC22A14 solute carrier family 22, member 14
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMO smoothened, frizzled class receptor
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
TBC1D8B TBC1 domain family, member 8B (with GRAM domain)
THRB thyroid hormone receptor, beta
TLR1 toll-like receptor 1
TMEM206 transmembrane protein 206
TRIM9 tripartite motif containing 9
TUBA3C tubulin, alpha 3c
UBQLN4 ubiquilin 4
VASH1 vasohibin 1
WDR25 WD repeat domain 25
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBED8 zinc finger, BED-type containing 8
ZBTB25 zinc finger and BTB domain containing 25
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF232 zinc finger protein 232
ZNF492 zinc finger protein 492
ZNF573 zinc finger protein 573
ZXDC ZXD family zinc finger C