altretamine-4627 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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192 genes differentially expressed following the altretamine-4627 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRG1 adhesion G protein-coupled receptor G1
ADRBK1 adrenergic, beta, receptor kinase 1
ANKRD6 ankyrin repeat domain 6
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APC adenomatous polyposis coli
BCL6 B-cell CLL/lymphoma 6
BNC1 basonuclin 1
C10ORF12 chromosome 10 open reading frame 12
C11ORF63 chromosome 11 open reading frame 63
C2CD2L C2CD2-like
C5AR1 complement component 5a receptor 1
C5ORF42 chromosome 5 open reading frame 42
CA12 carbonic anhydrase XII
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC85C coiled-coil domain containing 85C
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79B CD79b molecule, immunoglobulin-associated beta
CEP290 centrosomal protein 290kDa
CPB2 carboxypeptidase B2 (plasma)
CSF1 colony stimulating factor 1 (macrophage)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYBA cytochrome b-245, alpha polypeptide
DCAF11 DDB1 and CUL4 associated factor 11
DCN decorin
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FCAR Fc fragment of IgA receptor
FCF1 FCF1 rRNA-processing protein
GLRA1 glycine receptor, alpha 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GREB1L growth regulation by estrogen in breast cancer-like
HIC2 hypermethylated in cancer 2
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IL2 interleukin 2
INADL InaD-like (Drosophila)
INO80D INO80 complex subunit D
KLHL22 kelch-like family member 22
KRIT1 KRIT1, ankyrin repeat containing
LINC00115 long intergenic non-protein coding RNA 115
LPL lipoprotein lipase
MANBA mannosidase, beta A, lysosomal
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MOB3B MOB kinase activator 3B
MUC6 mucin 6, oligomeric mucus/gel-forming
MVB12B multivesicular body subunit 12B
MYL10 myosin, light chain 10, regulatory
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NCLN nicalin
NEB nebulin
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NRP1 neuropilin 1
OGFR opioid growth factor receptor
OR12D3 olfactory receptor, family 12, subfamily D, member 3
PACRG PARK2 co-regulated
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PARP8 poly (ADP-ribose) polymerase family, member 8
PCDH1 protocadherin 1
PCDHB3 protocadherin beta 3
PCNX pecanex homolog (Drosophila)
PDE4DIP phosphodiesterase 4D interacting protein
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G1B phospholipase A2, group IB (pancreas)
POM121 POM121 transmembrane nucleoporin
R3HCC1L R3H domain and coiled-coil containing 1-like
RANBP3 RAN binding protein 3
RASAL2 RAS protein activator like 2
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAGD Ras-related GTP binding D
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
RUNX1 runt-related transcription factor 1
SARM1 sterile alpha and TIR motif containing 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SETD1A SET domain containing 1A
SETDB1 SET domain, bifurcated 1
SLAMF7 SLAM family member 7
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOCS6 suppressor of cytokine signaling 6
SPRR2B small proline-rich protein 2B
SVIL supervillin
TCF4 transcription factor 4
THRB thyroid hormone receptor, beta
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM14 tripartite motif containing 14
TUBGCP2 tubulin, gamma complex associated protein 2
UBE2B ubiquitin-conjugating enzyme E2B
VCAN versican
WDR4 WD repeat domain 4
ZHX3 zinc fingers and homeoboxes 3

decreased expression

Symbol Name
ACE angiotensin I converting enzyme
ADGRB2 adhesion G protein-coupled receptor B2
AGO4 argonaute RISC catalytic component 4
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALOX12 arachidonate 12-lipoxygenase
ALPK1 alpha-kinase 1
ANG angiogenin, ribonuclease, RNase A family, 5
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BIN3 bridging integrator 3
C5ORF45 chromosome 5 open reading frame 45
CLCN5 chloride channel, voltage-sensitive 5
CLDN1 claudin 1
COG4 component of oligomeric golgi complex 4
COMP cartilage oligomeric matrix protein
CPNE7 copine VII
CXORF56 chromosome X open reading frame 56
DCAF4 DDB1 and CUL4 associated factor 4
DSE dermatan sulfate epimerase
EFNB1 ephrin-B1
ERCC4 excision repair cross-complementation group 4
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM120C family with sequence similarity 120C
FBRS fibrosin
FBXO2 F-box protein 2
FILIP1L filamin A interacting protein 1-like
FRMPD1 FERM and PDZ domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPR19 G protein-coupled receptor 19
GSTA3 glutathione S-transferase alpha 3
HIST1H2AG histone cluster 1, H2ag
HIST1H2AK histone cluster 1, H2ak
HIST1H2AL histone cluster 1, H2al
HIST1H3I histone cluster 1, H3i
HIST2H2AA3 histone cluster 2, H2aa3
HOXA1 homeobox A1
HPR haptoglobin-related protein
HRH2 histamine receptor H2
HYAL3 hyaluronoglucosaminidase 3
ICOS inducible T-cell co-stimulator
IFT140 intraflagellar transport 140
IGKV3-20 immunoglobulin kappa variable 3-20
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
JUNB jun B proto-oncogene
KIAA1456 KIAA1456
KLF13 Kruppel-like factor 13
KRT33A keratin 33A, type I
LIG4 ligase IV, DNA, ATP-dependent
LIME1 Lck interacting transmembrane adaptor 1
LINS lines homolog (Drosophila)
LOC100129648 uncharacterized LOC100129648
LOC100287590 uncharacterized LOC100287590
LY6D lymphocyte antigen 6 complex, locus D
MBTD1 mbt domain containing 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MTSS1L metastasis suppressor 1-like
MUC3B mucin 3B, cell surface associated
MYH15 myosin, heavy chain 15
NDP Norrie disease (pseudoglioma)
NEUROD1 neuronal differentiation 1
NPPB natriuretic peptide B
NR1H4 nuclear receptor subfamily 1, group H, member 4
NSUN6 NOP2/Sun domain family, member 6
NTF3 neurotrophin 3
OLFM4 olfactomedin 4
OR1G1 olfactory receptor, family 1, subfamily G, member 1
PCDH12 protocadherin 12
PDE8B phosphodiesterase 8B
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PISD phosphatidylserine decarboxylase
PRM2 protamine 2
PTK6 protein tyrosine kinase 6
RIMBP2 RIMS binding protein 2
RUNX1-IT1 RUNX1 intronic transcript 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SERGEF secretion regulating guanine nucleotide exchange factor
SLC25A40 solute carrier family 25, member 40
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SPINK1 serine peptidase inhibitor, Kazal type 1
ST20 suppressor of tumorigenicity 20
STAB2 stabilin 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TSNAXIP1 translin-associated factor X interacting protein 1
TSPAN2 tetraspanin 2
WNT1 wingless-type MMTV integration site family, member 1
ZFP30 ZFP30 zinc finger protein
ZNF208 zinc finger protein 208
ZNF276 zinc finger protein 276
ZXDC ZXD family zinc finger C