alpha-yohimbine-6274 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the alpha-yohimbine-6274 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1
ADTRP androgen-dependent TFPI-regulating protein
AHI1 Abelson helper integration site 1
APC adenomatous polyposis coli
APP amyloid beta (A4) precursor protein
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
BCAS1 breast carcinoma amplified sequence 1
BPGM 2,3-bisphosphoglycerate mutase
CCDC87 coiled-coil domain containing 87
CCL2 chemokine (C-C motif) ligand 2
CCRL2 chemokine (C-C motif) receptor-like 2
CD70 CD70 molecule
CDHR2 cadherin-related family member 2
CHKB choline kinase beta
CLN5 ceroid-lipofuscinosis, neuronal 5
COL6A1 collagen, type VI, alpha 1
CPQ carboxypeptidase Q
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLX2 distal-less homeobox 2
DNAI2 dynein, axonemal, intermediate chain 2
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FYB FYN binding protein
GMEB1 glucocorticoid modulatory element binding protein 1
GRM1 glutamate receptor, metabotropic 1
HDAC5 histone deacetylase 5
HOXC8 homeobox C8
INHBA inhibin, beta A
INPP5J inositol polyphosphate-5-phosphatase J
ITGB6 integrin, beta 6
IZUMO4 IZUMO family member 4
JMJD4 jumonji domain containing 4
KAT8 K(lysine) acetyltransferase 8
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIAA1109 KIAA1109
KLHL22 kelch-like family member 22
KRT16 keratin 16, type I
KRT31 keratin 31, type I
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LPPR2 lipid phosphate phosphatase-related protein type 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP4 microtubule-associated protein 4
MARK4 MAP/microtubule affinity-regulating kinase 4
MBNL2 muscleblind-like splicing regulator 2
NCKAP1 NCK-associated protein 1
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NPFFR1 neuropeptide FF receptor 1
NT5E 5'-nucleotidase, ecto (CD73)
OGFR opioid growth factor receptor
PAX8 paired box 8
PCDHGA1 protocadherin gamma subfamily A, 1
PDGFB platelet-derived growth factor beta polypeptide
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLSCR3 phospholipid scramblase 3
PLXNC1 plexin C1
PMS2P2 postmeiotic segregation increased 2 pseudogene 2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PTK6 protein tyrosine kinase 6
PVT1 Pvt1 oncogene (non-protein coding)
RAPSN receptor-associated protein of the synapse
RIMS2 regulating synaptic membrane exocytosis 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF2 ring finger protein 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SMTN smoothelin
SNAPC5 small nuclear RNA activating complex, polypeptide 5, 19kDa
SOGA1 suppressor of glucose, autophagy associated 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRRT serrate, RNA effector molecule
STEAP4 STEAP family member 4
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
TBX5 T-box 5
TGFB2 transforming growth factor, beta 2
TRAK1 trafficking protein, kinesin binding 1
TRD T cell receptor delta locus
TTBK2 tau tubulin kinase 2
TTC33 tetratricopeptide repeat domain 33
TTLL5 tubulin tyrosine ligase-like family member 5
TUBA3C tubulin, alpha 3c
UBE3A ubiquitin protein ligase E3A
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
ZBTB48 zinc finger and BTB domain containing 48
ZNF165 zinc finger protein 165
ZNF222 zinc finger protein 222
ZNF440 zinc finger protein 440
ZNF639 zinc finger protein 639
ZNF768 zinc finger protein 768

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACTL8 actin-like 8
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
ASB13 ankyrin repeat and SOCS box containing 13
ASPHD1 aspartate beta-hydroxylase domain containing 1
BAX BCL2-associated X protein
BPHL biphenyl hydrolase-like (serine hydrolase)
BSG basigin (Ok blood group)
C12ORF4 chromosome 12 open reading frame 4
C17ORF70 chromosome 17 open reading frame 70
C5AR2 complement component 5a receptor 2
CAPRIN2 caprin family member 2
CBX4 chromobox homolog 4
CHMP7 charged multivesicular body protein 7
CIDEB cell death-inducing DFFA-like effector b
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT3 DNA-damage-inducible transcript 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSCAM Down syndrome cell adhesion molecule
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR3 early growth response 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FA2H fatty acid 2-hydroxylase
FAM184A family with sequence similarity 184, member A
FAM86C1 family with sequence similarity 86, member C1
FBXW12 F-box and WD repeat domain containing 12
FOXC1 forkhead box C1
FUZ fuzzy planar cell polarity protein
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
H2AFY2 H2A histone family, member Y2
HIRA histone cell cycle regulator
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IER3IP1 immediate early response 3 interacting protein 1
IGFBP4 insulin-like growth factor binding protein 4
INO80D INO80 complex subunit D
KATNBL1 katanin p80 subunit B-like 1
KIAA0125 KIAA0125
KLHDC3 kelch domain containing 3
KPTN kaptin (actin binding protein)
LAMA3 laminin, alpha 3
LNPEP leucyl/cystinyl aminopeptidase
MBTD1 mbt domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEIS2 Meis homeobox 2
MITF microphthalmia-associated transcription factor
MVD mevalonate (diphospho) decarboxylase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO1E myosin IE
NPY5R neuropeptide Y receptor Y5
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PCGF1 polycomb group ring finger 1
PDZK1 PDZ domain containing 1
PGBD5 piggyBac transposable element derived 5
PHACTR4 phosphatase and actin regulator 4
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POLH polymerase (DNA directed), eta
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PYGB phosphorylase, glycogen; brain
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBL1 retinoblastoma-like 1
RFTN1 raftlin, lipid raft linker 1
RHOBTB1 Rho-related BTB domain containing 1
RNF126P1 ring finger protein 126 pseudogene 1
S100A4 S100 calcium binding protein A4
SDAD1 SDA1 domain containing 1
SETD8 SET domain containing (lysine methyltransferase) 8
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SOX3 SRY (sex determining region Y)-box 3
SSFA2 sperm specific antigen 2
STC2 stanniocalcin 2
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
TBCCD1 TBCC domain containing 1
TFF2 trefoil factor 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM180 transmembrane protein 180
TXLNG taxilin gamma
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR3 WD repeat domain 3
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB24 zinc finger and BTB domain containing 24
ZC3H3 zinc finger CCCH-type containing 3
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF770 zinc finger protein 770
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2
ZSCAN26 zinc finger and SCAN domain containing 26