alpha-estradiol-6930 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the alpha-estradiol-6930 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ADCK2 aarF domain containing kinase 2
AHI1 Abelson helper integration site 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ANKRD40 ankyrin repeat domain 40
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARNT aryl hydrocarbon receptor nuclear translocator
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BGN biglycan
BLVRA biliverdin reductase A
C17ORF80 chromosome 17 open reading frame 80
C2ORF72 chromosome 2 open reading frame 72
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CDK13 cyclin-dependent kinase 13
CEP68 centrosomal protein 68kDa
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COL5A1 collagen, type V, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CRYBG3 beta-gamma crystallin domain containing 3
CRYGC crystallin, gamma C
CYR61 cysteine-rich, angiogenic inducer, 61
DCAF11 DDB1 and CUL4 associated factor 11
DHODH dihydroorotate dehydrogenase (quinone)
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8
DNPEP aspartyl aminopeptidase
DVL3 dishevelled segment polarity protein 3
EAF2 ELL associated factor 2
EGR3 early growth response 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
GGT1 gamma-glutamyltransferase 1
GRK6 G protein-coupled receptor kinase 6
GTF2A1 general transcription factor IIA, 1, 19/37kDa
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HDAC11 histone deacetylase 11
HDAC4 histone deacetylase 4
HFE hemochromatosis
HIST1H2AB histone cluster 1, H2ab
ICOS inducible T-cell co-stimulator
IGLJ3 immunoglobulin lambda joining 3
IL15RA interleukin 15 receptor, alpha
KREMEN2 kringle containing transmembrane protein 2
LAMB3 laminin, beta 3
LIME1 Lck interacting transmembrane adaptor 1
LOC100127972 uncharacterized LOC100127972
LOC100129648 uncharacterized LOC100129648
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC23 leucine rich repeat containing 23
MAOA monoamine oxidase A
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MATK megakaryocyte-associated tyrosine kinase
MEIS1 Meis homeobox 1
MFN2 mitofusin 2
MKL1 megakaryoblastic leukemia (translocation) 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MPZL1 myelin protein zero-like 1
MRPS14 mitochondrial ribosomal protein S14
MTCP1 mature T-cell proliferation 1
MTRF1L mitochondrial translational release factor 1-like
MYBPC2 myosin binding protein C, fast type
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NKX3-2 NK3 homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
ORAI2 ORAI calcium release-activated calcium modulator 2
PDE4DIP phosphodiesterase 4D interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
RAB2A RAB2A, member RAS oncogene family
RP2 retinitis pigmentosa 2 (X-linked recessive)
RTEL1 regulator of telomere elongation helicase 1
SIN3B SIN3 transcription regulator family member B
SIPA1L3 signal-induced proliferation-associated 1 like 3
SIX3 SIX homeobox 3
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLN sarcolipin
SMG7-AS1 SMG7 antisense RNA 1
SOX9 SRY (sex determining region Y)-box 9
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
SRD5A3 steroid 5 alpha-reductase 3
TAT tyrosine aminotransferase
TDRD1 tudor domain containing 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TLE4 transducin-like enhancer of split 4
TMEM63A transmembrane protein 63A
TWF1 twinfilin actin binding protein 1
UNC93B1 unc-93 homolog B1 (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VLDLR very low density lipoprotein receptor
WDR62 WD repeat domain 62
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YLPM1 YLP motif containing 1
ZNF407 zinc finger protein 407
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ADRA2C adrenoceptor alpha 2C
AEN apoptosis enhancing nuclease
AGBL5 ATP/GTP binding protein-like 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
BBC3 BCL2 binding component 3
BCOR BCL6 corepressor
BPGM 2,3-bisphosphoglycerate mutase
C10ORF88 chromosome 10 open reading frame 88
C16ORF59 chromosome 16 open reading frame 59
C17ORF75 chromosome 17 open reading frame 75
CAPN15 calpain 15
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CGREF1 cell growth regulator with EF-hand domain 1
CHKB choline kinase beta
CLK1 CDC-like kinase 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
COCH cochlin
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
EVPL envoplakin
FAM188A family with sequence similarity 188, member A
FDXR ferredoxin reductase
FGD6 FYVE, RhoGEF and PH domain containing 6
FOXO1 forkhead box O1
GLCE glucuronic acid epimerase
GPR87 G protein-coupled receptor 87
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4
HIST1H2AG histone cluster 1, H2ag
HOXC13 homeobox C13
HSPA4L heat shock 70kDa protein 4-like
ICK intestinal cell (MAK-like) kinase
IFT22 intraflagellar transport 22
IRF2BP1 interferon regulatory factor 2 binding protein 1
JMJD1C jumonji domain containing 1C
KATNBL1 katanin p80 subunit B-like 1
KIAA0894 KIAA0894 protein
KIAA0922 KIAA0922
KLHL2 kelch-like family member 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LY6D lymphocyte antigen 6 complex, locus D
MAGEF1 melanoma antigen family F1
MAST3 microtubule associated serine/threonine kinase 3
METTL16 methyltransferase like 16
MORC3 MORC family CW-type zinc finger 3
NBAS neuroblastoma amplified sequence
NHEJ1 nonhomologous end-joining factor 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PACS1 phosphofurin acidic cluster sorting protein 1
PARP16 poly (ADP-ribose) polymerase family, member 16
PCBP4 poly(rC) binding protein 4
PDZRN3 PDZ domain containing ring finger 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PODXL2 podocalyxin-like 2
POTEKP POTE ankyrin domain family, member K, pseudogene
PRKX protein kinase, X-linked
PRODH proline dehydrogenase (oxidase) 1
PRR3 proline rich 3
PTDSS2 phosphatidylserine synthase 2
PTPRU protein tyrosine phosphatase, receptor type, U
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANGRF RAN guanine nucleotide release factor
RBM41 RNA binding motif protein 41
REPS2 RALBP1 associated Eps domain containing 2
RNF31 ring finger protein 31
RPH3AL rabphilin 3A-like (without C2 domains)
SALL2 spalt-like transcription factor 2
SCAMP3 secretory carrier membrane protein 3
SLC12A9 solute carrier family 12, member 9
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35F6 solute carrier family 35, member F6
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
STAG3 stromal antigen 3
SUN2 Sad1 and UNC84 domain containing 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMOD3 tropomodulin 3 (ubiquitous)
TSSC4 tumor suppressing subtransferable candidate 4
USP36 ubiquitin specific peptidase 36
VWA1 von Willebrand factor A domain containing 1
WDR44 WD repeat domain 44
ZBTB39 zinc finger and BTB domain containing 39
ZC3H12A zinc finger CCCH-type containing 12A
ZDHHC24 zinc finger, DHHC-type containing 24
ZMAT5 zinc finger, matrin-type 5
ZNF180 zinc finger protein 180
ZNF184 zinc finger protein 184
ZNF205 zinc finger protein 205
ZNF219 zinc finger protein 219
ZNF268 zinc finger protein 268
ZNF654 zinc finger protein 654
ZNF675 zinc finger protein 675
ZNF767P zinc finger family member 767, pseudogene
ZNF778 zinc finger protein 778
ZNF816 zinc finger protein 816