alpha-estradiol-1210 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the alpha-estradiol-1210 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADRBK1 adrenergic, beta, receptor kinase 1
ALPK3 alpha-kinase 3
ARHGAP22 Rho GTPase activating protein 22
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATAD5 ATPase family, AAA domain containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF10 chromosome 10 open reading frame 10
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CACTIN cactin, spliceosome C complex subunit
CD300C CD300c molecule
CD53 CD53 molecule
CEP164 centrosomal protein 164kDa
CEP170B centrosomal protein 170B
CHML choroideremia-like (Rab escort protein 2)
CHMP6 charged multivesicular body protein 6
CHPF2 chondroitin polymerizing factor 2
CLDN11 claudin 11
CLEC4E C-type lectin domain family 4, member E
CORO1B coronin, actin binding protein, 1B
CRY2 cryptochrome circadian clock 2
CTAGE5 CTAGE family, member 5
CTNS cystinosin, lysosomal cystine transporter
DDN dendrin
DHODH dihydroorotate dehydrogenase (quinone)
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOCK6 dedicator of cytokinesis 6
EPS8L1 EPS8-like 1
ESR1 estrogen receptor 1
FGFR1 fibroblast growth factor receptor 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FYN FYN proto-oncogene, Src family tyrosine kinase
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GEMIN7 gem (nuclear organelle) associated protein 7
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GTSE1 G-2 and S-phase expressed 1
HAL histidine ammonia-lyase
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIST1H2BO histone cluster 1, H2bo
HOXA4 homeobox A4
HOXB2 homeobox B2
IFI44L interferon-induced protein 44-like
IFT27 intraflagellar transport 27
INO80B INO80 complex subunit B
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KIAA0754 KIAA0754
KRIT1 KRIT1, ankyrin repeat containing
KRT86 keratin 86, type II
KYNU kynureninase
LINC00260 long intergenic non-protein coding RNA 260
MAPK8 mitogen-activated protein kinase 8
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MPPE1 metallophosphoesterase 1
MTA2 metastasis associated 1 family, member 2
MX1 MX dynamin-like GTPase 1
MYL10 myosin, light chain 10, regulatory
NF1 neurofibromin 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OSMR oncostatin M receptor
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PAIP2B poly(A) binding protein interacting protein 2B
PHF3 PHD finger protein 3
PLXND1 plexin D1
RAD51B RAD51 paralog B
RGS10 regulator of G-protein signaling 10
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SETD8 SET domain containing (lysine methyltransferase) 8
SFXN3 sideroflexin 3
SH2D4A SH2 domain containing 4A
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SMG5 SMG5 nonsense mediated mRNA decay factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TAPBP TAP binding protein (tapasin)
TBXA2R thromboxane A2 receptor
TCP11L1 t-complex 11, testis-specific-like 1
TEP1 telomerase-associated protein 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLDC1 TBC/LysM-associated domain containing 1
TMEM74B transmembrane protein 74B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRIM25 tripartite motif containing 25
TRMT61A tRNA methyltransferase 61A
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UPF3A UPF3 regulator of nonsense transcripts homolog A (yeast)
USB1 U6 snRNA biogenesis 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
WNK1 WNK lysine deficient protein kinase 1
ZBTB1 zinc finger and BTB domain containing 1
ZNF467 zinc finger protein 467
ZNF573 zinc finger protein 573
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
ADCY6 adenylate cyclase 6
ALPK1 alpha-kinase 1
ANOS1 anosmin 1
ANXA2P3 annexin A2 pseudogene 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARRB2 arrestin, beta 2
ATG9A autophagy related 9A
BIK BCL2-interacting killer (apoptosis-inducing)
C11ORF63 chromosome 11 open reading frame 63
CCDC94 coiled-coil domain containing 94
CCL20 chemokine (C-C motif) ligand 20
CD70 CD70 molecule
CNTNAP3B contactin associated protein-like 3B
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CTPS2 CTP synthase 2
CTSO cathepsin O
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DEPTOR DEP domain containing MTOR-interacting protein
EFCAB2 EF-hand calcium binding domain 2
ELP3 elongator acetyltransferase complex subunit 3
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM214B family with sequence similarity 214, member B
FANCF Fanconi anemia, complementation group F
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FUZ fuzzy planar cell polarity protein
GALT galactose-1-phosphate uridylyltransferase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPALPP1 GPALPP motifs containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HOXC10 homeobox C10
HS1BP3 HCLS1 binding protein 3
IL17RB interleukin 17 receptor B
JAM3 junctional adhesion molecule 3
KIF13B kinesin family member 13B
KIF1B kinesin family member 1B
KRT15 keratin 15, type I
LMBR1L limb development membrane protein 1-like
LPAR6 lysophosphatidic acid receptor 6
MAGOHB mago-nashi homolog B (Drosophila)
MAPK12 mitogen-activated protein kinase 12
MCC mutated in colorectal cancers
MPP1 membrane protein, palmitoylated 1, 55kDa
MTG1 mitochondrial ribosome-associated GTPase 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDE1 nudE neurodevelopment protein 1
NDP Norrie disease (pseudoglioma)
NOL6 nucleolar protein 6 (RNA-associated)
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NT5DC3 5'-nucleotidase domain containing 3
OLFML2A olfactomedin-like 2A
ORAI3 ORAI calcium release-activated calcium modulator 3
OSR2 odd-skipped related transciption factor 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCYT2 phosphate cytidylyltransferase 2, ethanolamine
PDGFRL platelet-derived growth factor receptor-like
PEX26 peroxisomal biogenesis factor 26
PHC1 polyhomeotic homolog 1 (Drosophila)
PHLDA3 pleckstrin homology-like domain, family A, member 3
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
POMT2 protein-O-mannosyltransferase 2
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PTK6 protein tyrosine kinase 6
RAB4B RAB4B, member RAS oncogene family
RARS arginyl-tRNA synthetase
RBM38 RNA binding motif protein 38
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF146 ring finger protein 146
SCUBE3 signal peptide, CUB domain, EGF-like 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SH3BGR SH3 domain binding glutamate-rich protein
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SNPH syntaphilin
SOX12 SRY (sex determining region Y)-box 12
SPATA7 spermatogenesis associated 7
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYNPO synaptopodin
SYT17 synaptotagmin XVII
TCTN2 tectonic family member 2
TINAGL1 tubulointerstitial nephritis antigen-like 1
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM57 transmembrane protein 57
TMOD3 tropomodulin 3 (ubiquitous)
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM9 tripartite motif containing 9
TUBB2B tubulin, beta 2B class IIb
TUBG2 tubulin, gamma 2
UBAC1 UBA domain containing 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZNF324 zinc finger protein 324
ZNF574 zinc finger protein 574
ZNF767P zinc finger family member 767, pseudogene
ZNF816 zinc finger protein 816
ZNHIT2 zinc finger, HIT-type containing 2