alpha thalassemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes. (Human Disease Ontology, DOID_1099)
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Genes

112 genes co-occuring with the disease alpha thalassemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 2.69501
ATRX alpha thalassemia/mental retardation syndrome X-linked 2.68734
HBA2 hemoglobin, alpha 2 2.66105
HBG2 hemoglobin, gamma G 2.17812
HBZ hemoglobin, zeta 2.17284
HBE1 hemoglobin, epsilon 1 2.1582
HBB hemoglobin, beta 2.14685
SCN2A sodium channel, voltage gated, type II alpha subunit 1.94971
HBQ1 hemoglobin, theta 1 1.78849
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 1.568
HBD hemoglobin, delta 1.55336
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.48516
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.42454
G6PD glucose-6-phosphate dehydrogenase 1.32236
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 1.18109
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 1.12656
KRT40 keratin 40, type I 1.0109
FTL ferritin, light polypeptide 1.00372
AHSP alpha hemoglobin stabilizing protein 1.0033
FTH1 ferritin, heavy polypeptide 1 1.0033
DAXX death-domain associated protein 1.00035
MED20 mediator complex subunit 20 0.995283
IGBP1 immunoglobulin (CD79A) binding protein 1 0.919673
CBX5 chromobox homolog 5 0.901567
SAMHD1 SAM domain and HD domain 1 0.881882
LUC7L LUC7-like (S. cerevisiae) 0.851173
EPB41 erythrocyte membrane protein band 4.1 0.836017
OPHN1 oligophrenin 1 0.793361
RAD54L2 RAD54-like 2 (S. cerevisiae) 0.78066
SPTB spectrin, beta, erythrocytic 0.78066
TFRC transferrin receptor 0.771252
SOX8 SRY (sex determining region Y)-box 8 0.770435
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma 0.730571
PHPT1 phosphohistidine phosphatase 1 0.722482
HBS1L HBS1-like translational GTPase 0.720058
PIGH phosphatidylinositol glycan anchor biosynthesis, class H 0.709975
EPPIN epididymal peptidase inhibitor 0.691896
BAIAP3 BAI1-associated protein 3 0.678701
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.636708
MECP2 methyl CpG binding protein 2 0.619834
PQBP1 polyglutamine binding protein 1 0.597961
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 0.595233
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit 0.594454
IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) 0.572273
PKLR pyruvate kinase, liver and RBC 0.567997
PIGC phosphatidylinositol glycan anchor biosynthesis, class C 0.553627
CHD3 chromodomain helicase DNA binding protein 3 0.553239
EPB42 erythrocyte membrane protein band 4.2 0.552851
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.527676
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 0.52729
MED25 mediator complex subunit 25 0.525746
PGD phosphogluconate dehydrogenase 0.513802
INTU inturned planar cell polarity protein 0.501527
PKM pyruvate kinase, muscle 0.500761
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.498085
TF transferrin 0.490835
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.47753
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.468819
HIST1H3D histone cluster 1, H3d 0.46655
HIST1H3B histone cluster 1, H3b 0.46655
HIST1H3I histone cluster 1, H3i 0.46655
HIST1H3G histone cluster 1, H3g 0.46655
HIST1H3F histone cluster 1, H3f 0.46655
HIST1H3J histone cluster 1, H3j 0.46655
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.451454
HIST1H3E histone cluster 1, H3e 0.451454
HIST1H3H histone cluster 1, H3h 0.451454
HIST1H3A histone cluster 1, H3a 0.451454
HIST1H3C histone cluster 1, H3c 0.451454
DNAH8 dynein, axonemal, heavy chain 8 0.436778
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.42664
RAD54L RAD54-like (S. cerevisiae) 0.41727
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.368518
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.347144
BTG3 BTG family, member 3 0.343473
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 0.335778
RTN3 reticulon 3 0.32701
FABP9 fatty acid binding protein 9, testis 0.307395
TRIM5 tripartite motif containing 5 0.300533
HP haptoglobin 0.298371
HPR haptoglobin-related protein 0.292616
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.288668
SOX9 SRY (sex determining region Y)-box 9 0.282225
HBG1 hemoglobin, gamma A 0.275801
CYGB cytoglobin 0.272953
OR51B5 olfactory receptor, family 51, subfamily B, member 5 0.268687
SCARB2 scavenger receptor class B, member 2 0.263368
PLEKHN1 pleckstrin homology domain containing, family N member 1 0.26266
CD36 CD36 molecule (thrombospondin receptor) 0.248905
H3F3B H3 histone, family 3B (H3.3B) 0.238403
H3F3A H3 histone, family 3A 0.238403
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.23666
PDS5B PDS5 cohesin associated factor B 0.23492
KDM5C lysine (K)-specific demethylase 5C 0.234225
DMRT1 doublesex and mab-3 related transcription factor 1 0.231102
SRY sex determining region Y 0.213283
SOX10 SRY (sex determining region Y)-box 10 0.212271
SCARB1 scavenger receptor class B, member 1 0.211261
CD59 CD59 molecule, complement regulatory protein 0.210925
PML promyelocytic leukemia 0.210589
ADCY9 adenylate cyclase 9 0.200331
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.197099
PTK2 protein tyrosine kinase 2 0.196139
FNDC3A fibronectin type III domain containing 3A 0.1936
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.191097
ADD2 adducin 2 (beta) 0.18591
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.175146
ACTB actin, beta 0.173314
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.172038
PGK1 phosphoglycerate kinase 1 0.169812
MYB v-myb avian myeloblastosis viral oncogene homolog 0.166095
POLL polymerase (DNA directed), lambda 0.162306