allergic rhinitis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites. (Human Disease Ontology, DOID_4481)
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Genes

358 genes co-occuring with the disease allergic rhinitis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
RNASE3 ribonuclease, RNase A family, 3 2.40105
HRH1 histamine receptor H1 2.20363
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 2.00974
RENBP renin binding protein 1.77225
PDC phosducin 1.7555
PFN4 profilin family, member 4 1.72912
IL5 interleukin 5 1.70952
IL4 interleukin 4 1.67864
PFN1 profilin 1 1.65925
PFN2 profilin 2 1.64936
PTGDR2 prostaglandin D2 receptor 2 1.64487
PDCL phosducin-like 1.62291
CD4 CD4 molecule 1.54363
TSLP thymic stromal lymphopoietin 1.51984
TAC1 tachykinin, precursor 1 1.47945
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.44298
ICAM1 intercellular adhesion molecule 1 1.40089
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.40001
FLG filaggrin 1.37774
EPX eosinophil peroxidase 1.35943
NPS neuropeptide S 1.28435
GATA3 GATA binding protein 3 1.28304
FOXP3 forkhead box P3 1.28086
CCR3 chemokine (C-C motif) receptor 3 1.27563
CD79A CD79a molecule, immunoglobulin-associated alpha 1.27344
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.22865
ALB albumin 1.22432
CCL17 chemokine (C-C motif) ligand 17 1.22302
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 1.21522
CYSLTR2 cysteinyl leukotriene receptor 2 1.19229
HRH4 histamine receptor H4 1.18582
IL13 interleukin 13 1.17765
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 1.14942
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 1.13247
MRPL4 mitochondrial ribosomal protein L4 1.12614
IGHE immunoglobulin heavy constant epsilon 1.11225
TBX21 T-box 21 1.08873
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 1.08621
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 1.07908
SLC25A46 solute carrier family 25, member 46 1.06522
VCAM1 vascular cell adhesion molecule 1 1.03451
KNG1 kininogen 1 1.02018
VIP vasoactive intestinal peptide 1.01047
IL4R interleukin 4 receptor 1.00625
CMA1 chymase 1, mast cell 1.00119
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.980952
YBX2 Y box binding protein 2 0.964148
SYK spleen tyrosine kinase 0.959123
CCL24 chemokine (C-C motif) ligand 24 0.952021
LOXL1 lysyl oxidase-like 1 0.951187
CYSLTR1 cysteinyl leukotriene receptor 1 0.949936
KIAA0101 KIAA0101 0.929587
TGFB1 transforming growth factor, beta 1 0.922149
CCL22 chemokine (C-C motif) ligand 22 0.921323
TNF tumor necrosis factor 0.917611
PTGDR prostaglandin D2 receptor (DP) 0.916375
TBXA2R thromboxane A2 receptor 0.913492
CCL11 chemokine (C-C motif) ligand 11 0.888438
SDAD1 SDA1 domain containing 1 0.885979
MPO myeloperoxidase 0.882292
CLC Charcot-Leyden crystal galectin 0.878605
ALOX5 arachidonate 5-lipoxygenase 0.876966
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.873281
IK IK cytokine, down-regulator of HLA II 0.867549
NGF nerve growth factor (beta polypeptide) 0.860999
TLR9 toll-like receptor 9 0.846259
IL1RL1 interleukin 1 receptor-like 1 0.84585
CCL26 chemokine (C-C motif) ligand 26 0.843802
HRH2 histamine receptor H2 0.838885
TAS2R4 taste receptor, type 2, member 4 0.837246
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.818385
TIMD4 T-cell immunoglobulin and mucin domain containing 4 0.804436
LRRC32 leucine rich repeat containing 32 0.800744
ADAM33 ADAM metallopeptidase domain 33 0.788033
CCL13 chemokine (C-C motif) ligand 13 0.787213
SCP2 sterol carrier protein 2 0.783526
LYZ lysozyme 0.771252
CLCN3 chloride channel, voltage-sensitive 3 0.764718
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.761454
BPIFA1 BPI fold containing family A, member 1 0.761047
ACR acrosin 0.752085
MED28 mediator complex subunit 28 0.751678
LTC4S leukotriene C4 synthase 0.741923
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.736649
IL1B interleukin 1, beta 0.735433
LTF lactotransferrin 0.731786
TPT1 tumor protein, translationally-controlled 1 0.728143
PXYLP1 2-phosphoxylose phosphatase 1 0.706754
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.700321
IL31 interleukin 31 0.694301
SELE selectin E 0.691495
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.689492
TLR4 toll-like receptor 4 0.688692
IL16 interleukin 16 0.669538
IL17A interleukin 17A 0.65763
ALK anaplastic lymphoma receptor tyrosine kinase 0.656441
CD86 CD86 molecule 0.650508
CXCL8 chemokine (C-X-C motif) ligand 8 0.650113
CARD17 caspase recruitment domain family, member 17 0.646165
TUBA3C tubulin, alpha 3c 0.644981
C11ORF30 chromosome 11 open reading frame 30 0.642221
TACR1 tachykinin receptor 1 0.641039
IL10 interleukin 10 0.641039
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.631598
CD68 CD68 molecule 0.629635
TAS2R30 taste receptor, type 2, member 30 0.628065
PHF11 PHD finger protein 11 0.625711
FADS2 fatty acid desaturase 2 0.6214
HNMT histamine N-methyltransferase 0.615138
TMEM232 transmembrane protein 232 0.615138
MIR187 microRNA 187 0.615138
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.609666
AQP5 aquaporin 5 0.604981
TLR6 toll-like receptor 6 0.591727
RORC RAR-related orphan receptor C 0.589001
LEAP2 liver expressed antimicrobial peptide 2 0.587833
HLA-G major histocompatibility complex, class I, G 0.586665
CD63 CD63 molecule 0.578883
SOCS5 suppressor of cytokine signaling 5 0.577716
ACTB actin, beta 0.572662
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.569941
CD40 CD40 molecule, TNF receptor superfamily member 5 0.567609
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 0.56722
TIMP1 TIMP metallopeptidase inhibitor 1 0.566054
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.564889
MMP9 matrix metallopeptidase 9 0.5645
NOD1 nucleotide-binding oligomerization domain containing 1 0.556344
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.554403
NELFCD negative elongation factor complex member C/D 0.552851
TAS2R14 taste receptor, type 2, member 14 0.552851
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.552463
CD80 CD80 molecule 0.550522
INS insulin 0.549747
CLCA1 chloride channel accessory 1 0.548971
CCR8 chemokine (C-C motif) receptor 8 0.541992
ACTG1 actin gamma 1 0.541605
TLR2 toll-like receptor 2 0.533088
RAX2 retina and anterior neural fold homeobox 2 0.527676
POMC proopiomelanocortin 0.51919
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.518034
SELL selectin L 0.517649
HDC histidine decarboxylase 0.517649
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.516494
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.509959
MIPOL1 mirror-image polydactyly 1 0.509576
EBI3 Epstein-Barr virus induced 3 0.506123
IL17RB interleukin 17 receptor B 0.505356
IL18 interleukin 18 0.503058
TSPO translocator protein (18kDa) 0.500379
FADS1 fatty acid desaturase 1 0.499231
FAM21C family with sequence similarity 21, member C 0.496175
PARM1 prostate androgen-regulated mucin-like protein 1 0.493122
CXCL10 chemokine (C-X-C motif) ligand 10 0.491978
SCGB3A2 secretoglobin, family 3A, member 2 0.482084
SCG2 secretogranin II 0.480945
S100A7 S100 calcium binding protein A7 0.475634
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.474498
IL33 interleukin 33 0.472225
CSN1S1 casein alpha s1 0.468819
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.458619
LOR loricrin 0.453339
JUN jun proto-oncogene 0.452962
IL3 interleukin 3 0.452208
TLR7 toll-like receptor 7 0.448441
CHIA chitinase, acidic 0.448441
CD19 CD19 molecule 0.446935
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.446558
TPSAB1 tryptase alpha/beta 1 0.446182
IQGAP3 IQ motif containing GTPase activating protein 3 0.444676
ZFPM1 zinc finger protein, FOG family member 1 0.438282
IL2RA interleukin 2 receptor, alpha 0.429642
IL32 interleukin 32 0.429266
IL6 interleukin 6 0.429266
HPGDS hematopoietic prostaglandin D synthase 0.425514
GBP5 guanylate binding protein 5 0.425514
CCL4 chemokine (C-C motif) ligand 4 0.424765
CALCA calcitonin-related polypeptide alpha 0.424014
IFNGR1 interferon gamma receptor 1 0.422515
NARS asparaginyl-tRNA synthetase 0.421016
CCL27 chemokine (C-C motif) ligand 27 0.421016
MIRLET7E microRNA let-7e 0.420641
HRH3 histamine receptor H3 0.418768
CPLX4 complexin 4 0.416896
FOXJ1 forkhead box J1 0.416521
C5AR1 complement component 5a receptor 1 0.415024
SART1 squamous cell carcinoma antigen recognized by T cells 0.405305
CD40LG CD40 ligand 0.405305
IL9 interleukin 9 0.404184
ORAI1 ORAI calcium release-activated calcium modulator 1 0.399334
RIT2 Ras-like without CAAX 2 0.398962
CTH cystathionine gamma-lyase 0.395608
SFTPA2 surfactant protein A2 0.394863
NOS3 nitric oxide synthase 3 (endothelial cell) 0.391141
CALML5 calmodulin-like 5 0.389281
NOS2 nitric oxide synthase 2, inducible 0.387423
PALD1 phosphatase domain containing, paladin 1 0.384079
FGA fibrinogen alpha chain 0.37592
SOCS3 suppressor of cytokine signaling 3 0.371107
CXCR3 chemokine (C-X-C motif) receptor 3 0.368518
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.366301
SETDB2 SET domain, bifurcated 2 0.366301
CD300LF CD300 molecule-like family member f 0.365932
CXCL11 chemokine (C-X-C motif) ligand 11 0.363347
LTB4R leukotriene B4 receptor 0.358183
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.354868
IL2 interleukin 2 0.353027
CCL20 chemokine (C-C motif) ligand 20 0.350084
ADGRG6 adhesion G protein-coupled receptor G6 0.348614
WNT2B wingless-type MMTV integration site family, member 2B 0.344574
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.344574
CD276 CD276 molecule 0.344207
KIF5C kinesin family member 5C 0.34384
CHIT1 chitinase 1 (chitotriosidase) 0.340906
MUC19 mucin 19, oligomeric 0.340173
TMEM45A transmembrane protein 45A 0.338341
BDNF brain-derived neurotrophic factor 0.337608
DEXI Dexi homolog (mouse) 0.334315
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.333949
ZBTB10 zinc finger and BTB domain containing 10 0.32701
IL18R1 interleukin 18 receptor 1 0.326646
COL6A5 collagen, type VI, alpha 5 0.32373
TLR8 toll-like receptor 8 0.318635
ADAT3 adenosine deaminase, tRNA-specific 3 0.316456
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.315366
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.313915
HRK harakiri, BCL2 interacting protein 0.312827
ITSN2 intersectin 2 0.312102
CCL2 chemokine (C-C motif) ligand 2 0.311739
FLNC filamin C, gamma 0.311377
CXCR1 chemokine (C-X-C motif) receptor 1 0.310652
PI15 peptidase inhibitor 15 0.31029
AICDA activation-induced cytidine deaminase 0.309566
LARS leucyl-tRNA synthetase 0.306672
CCL7 chemokine (C-C motif) ligand 7 0.295492
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.285802
CRP C-reactive protein, pentraxin-related 0.285086
ATAD3A ATPase family, AAA domain containing 3A 0.28294
ELANE elastase, neutrophil expressed 0.280082
PLA2G1B phospholipase A2, group IB (pancreas) 0.279367
TIMP2 TIMP metallopeptidase inhibitor 2 0.27794
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.275089
CDIP1 cell death-inducing p53 target 1 0.274376
TNS3 tensin 3 0.272953
PHIP pleckstrin homology domain interacting protein 0.270108
NPY neuropeptide Y 0.269043
IFNG interferon, gamma 0.268687
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.265849
SFTPA1 surfactant protein A1 0.265494
SLPI secretory leukocyte peptidase inhibitor 0.263014
EHF ets homologous factor 0.261599
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) 0.260184
CCL19 chemokine (C-C motif) ligand 19 0.25983
GLYATL1 glycine-N-acyltransferase-like 1 0.259124
TCHH trichohyalin 0.25877
NPSR1 neuropeptide S receptor 1 0.256652
GSDMA gasdermin A 0.255946
ELP2 elongator acetyltransferase complex subunit 2 0.255241
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.253831
LEP leptin 0.252422
RIPK2 receptor-interacting serine-threonine kinase 2 0.25207
CCL14 chemokine (C-C motif) ligand 14 0.249608
GOLIM4 golgi integral membrane protein 4 0.248554
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64) 0.245046
IRAK4 interleukin-1 receptor-associated kinase 4 0.243295
GCOM1 GRINL1A complex locus 1 0.243295
CLDN1 claudin 1 0.242945
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.242945
IDO1 indoleamine 2,3-dioxygenase 1 0.240847
IL23R interleukin 23 receptor 0.239101
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.237706
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.237357
IL1RN interleukin 1 receptor antagonist 0.235616
IVD isovaleryl-CoA dehydrogenase 0.234573
CD9 CD9 molecule 0.234573
SIGLEC14 sialic acid binding Ig-like lectin 14 0.234225
SELM selenoprotein M 0.233878
RNASE7 ribonuclease, RNase A family, 7 0.23353
NAGS N-acetylglutamate synthase 0.232836
ADSL adenylosuccinate lyase 0.232489
CXCL9 chemokine (C-X-C motif) ligand 9 0.230755
CLDN7 claudin 7 0.230409
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.230063
C3AR1 complement component 3a receptor 1 0.227988
IL7R interleukin 7 receptor 0.227988
PDE4A phosphodiesterase 4A, cAMP-specific 0.227642
JCHAIN joining chain of multimeric IgA and IgM 0.226607
MANEAL mannosidase, endo-alpha-like 0.225917
IL13RA1 interleukin 13 receptor, alpha 1 0.225573
PHLDB1 pleckstrin homology-like domain, family B, member 1 0.224884
HAND1 heart and neural crest derivatives expressed 1 0.22454
PPT1 palmitoyl-protein thioesterase 1 0.223853
ITK IL2-inducible T-cell kinase 0.221793
CCL5 chemokine (C-C motif) ligand 5 0.221108
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.21974
CST1 cystatin SN 0.219057
CD22 CD22 molecule 0.217012
MMP23B matrix metallopeptidase 23B 0.214975
RIN1 Ras and Rab interactor 1 0.213283
MUC2 mucin 2, oligomeric mucus/gel-forming 0.213283
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.213283
NAAA N-acylethanolamine acid amidase 0.212945
DPT dermatopontin 0.212271
CCL3 chemokine (C-C motif) ligand 3 0.210925
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.210589
LAG3 lymphocyte-activation gene 3 0.208245
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 0.207912
PRAMEF10 PRAME family member 10 0.205585
CCDC26 CCDC26 long non-coding RNA 0.204263
NOL9 nucleolar protein 9 0.201635
IFNLR1 interferon, lambda receptor 1 0.200982
CCDC130 coiled-coil domain containing 130 0.200006
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.200006
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.199356
GSTP1 glutathione S-transferase pi 1 0.199356
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.199356
CHRM3 cholinergic receptor, muscarinic 3 0.199356
ASIC3 acid sensing (proton gated) ion channel 3 0.199356
WDR11 WD repeat domain 11 0.198064
CCR2 chemokine (C-C motif) receptor 2 0.19582
CD164 CD164 molecule, sialomucin 0.194548
MID2 midline 2 0.193915
PANX2 pannexin 2 0.193285
GPS1 G protein pathway suppressor 1 0.192031
TAC4 tachykinin 4 (hemokinin) 0.188938
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.188022
FAM134B family with sequence similarity 134, member B 0.185612
CCL21 chemokine (C-C motif) ligand 21 0.184424
DACT3 dishevelled-binding antagonist of beta-catenin 3 0.183248
CKLF chemokine-like factor 0.182375
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.182375
CD69 CD69 molecule 0.181798
CD84 CD84 molecule 0.180937
HLA-A major histocompatibility complex, class I, A 0.179239
MMP2 matrix metallopeptidase 2 0.178682
FAM188A family with sequence similarity 188, member A 0.178682
SPINK5 serine peptidase inhibitor, Kazal type 5 0.177851
IL3RA interleukin 3 receptor, alpha (low affinity) 0.177851
CD1C CD1c molecule 0.175679
OSBP oxysterol binding protein 0.175146
SIGLEC8 sialic acid binding Ig-like lectin 8 0.172291
IL19 interleukin 19 0.171036
GUSB glucuronidase, beta 0.170299
MC5R melanocortin 5 receptor 0.169812
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.169571
DEFB1 defensin, beta 1 0.165874
MST1R macrophage stimulating 1 receptor 0.164571
HBA2 hemoglobin, alpha 2 0.164149
TRPM8 transient receptor potential cation channel, subfamily M, member 8 0.163938
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.163523
FLNA filamin A, alpha 0.162908
HES5 hes family bHLH transcription factor 5 0.161912
OCLN occludin 0.160948
C1ORF174 chromosome 1 open reading frame 174 0.160387
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.160203
ICAM2 intercellular adhesion molecule 2 0.159302
IL23A interleukin 23, alpha subunit p19 0.159124
TPM1 tropomyosin 1 (alpha) 0.157929
PRNT prion protein (testis specific) 0.157602