alfaxalone-3135 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the alfaxalone-3135 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN2 actinin, alpha 2
AHNAK AHNAK nucleoprotein
AKAP8L A kinase (PRKA) anchor protein 8-like
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BMP7 bone morphogenetic protein 7
C1ORF61 chromosome 1 open reading frame 61
C2ORF72 chromosome 2 open reading frame 72
CADM4 cell adhesion molecule 4
CAPN9 calpain 9
CCDC181 coiled-coil domain containing 181
CDRT1 CMT1A duplicated region transcript 1
CFAP69 cilia and flagella associated protein 69
CFAP74 cilia and flagella associated protein 74
CNGB3 cyclic nucleotide gated channel beta 3
CNOT4 CCR4-NOT transcription complex, subunit 4
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL5A2 collagen, type V, alpha 2
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPN2 carboxypeptidase N, polypeptide 2
CTSF cathepsin F
CX3CL1 chemokine (C-X3-C motif) ligand 1
DRD2 dopamine receptor D2
DSTYK dual serine/threonine and tyrosine protein kinase
E2F5 E2F transcription factor 5, p130-binding
FAM127B family with sequence similarity 127, member B
FN1 fibronectin 1
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GDNF glial cell derived neurotrophic factor
GJA8 gap junction protein, alpha 8, 50kDa
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPM6A glycoprotein M6A
GPR153 G protein-coupled receptor 153
GRM7 glutamate receptor, metabotropic 7
HCRTR2 hypocretin (orexin) receptor 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H3I histone cluster 1, H3i
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HSPA2 heat shock 70kDa protein 2
IFNA4 interferon, alpha 4
IGSF1 immunoglobulin superfamily, member 1
INADL InaD-like (Drosophila)
KLF3 Kruppel-like factor 3 (basic)
KLK7 kallikrein-related peptidase 7
LENEP lens epithelial protein
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
LOC100131532 uncharacterized LOC100131532
MAGEC1 melanoma antigen family C1
MAP4 microtubule-associated protein 4
MAU2 MAU2 sister chromatid cohesion factor
MID1 midline 1
MIER2 mesoderm induction early response 1, family member 2
MUC1 mucin 1, cell surface associated
MYO6 myosin VI
NRG2 neuregulin 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML2A olfactomedin-like 2A
PDE4DIP phosphodiesterase 4D interacting protein
PPARD peroxisome proliferator-activated receptor delta
PRDM9 PR domain containing 9
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKCE protein kinase C, epsilon
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB6B RAB6B, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RIN1 Ras and Rab interactor 1
RYR2 ryanodine receptor 2 (cardiac)
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SDS serine dehydratase
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SEZ6L seizure related 6 homolog (mouse)-like
SH2D2A SH2 domain containing 2A
SLC39A9 solute carrier family 39, member 9
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNAI1 snail family zinc finger 1
SNX24 sorting nexin 24
SORBS3 sorbin and SH3 domain containing 3
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22B TBC1 domain family, member 22B
TCHH trichohyalin
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TEF thyrotrophic embryonic factor
THBS1 thrombospondin 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNNT3 troponin T type 3 (skeletal, fast)
TRD T cell receptor delta locus
TSPAN6 tetraspanin 6
ULBP1 UL16 binding protein 1
UNC119 unc-119 homolog (C. elegans)
VCX2 variable charge, X-linked 2
ZNF407 zinc finger protein 407
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
ADORA3 adenosine A3 receptor
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
AREL1 apoptosis resistant E3 ubiquitin protein ligase 1
ARHGAP4 Rho GTPase activating protein 4
ARMC7 armadillo repeat containing 7
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C16ORF59 chromosome 16 open reading frame 59
CAPN15 calpain 15
CBX7 chromobox homolog 7
CCNT1 cyclin T1
CD180 CD180 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD48 CD48 molecule
CDCP1 CUB domain containing protein 1
CDK6 cyclin-dependent kinase 6
CECR1 cat eye syndrome chromosome region, candidate 1
CEP295 centrosomal protein 295kDa
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLDN15 claudin 15
CNTN1 contactin 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGKG diacylglycerol kinase, gamma 90kDa
DNAAF2 dynein, axonemal, assembly factor 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DRAM1 DNA-damage regulated autophagy modulator 1
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EXD3 exonuclease 3'-5' domain containing 3
FOXO4 forkhead box O4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GALE UDP-galactose-4-epimerase
GPATCH2L G patch domain containing 2-like
HIST1H1T histone cluster 1, H1t
HOXA5 homeobox A5
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGLV1-44 immunoglobulin lambda variable 1-44
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNK5 potassium channel, two pore domain subfamily K, member 5
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LNPEP leucyl/cystinyl aminopeptidase
LOC100286895 cell division cycle 27 homolog pseudogene
MAK male germ cell-associated kinase
MCTP2 multiple C2 domains, transmembrane 2
MKL2 MKL/myocardin-like 2
MOCS3 molybdenum cofactor synthesis 3
MTCP1 mature T-cell proliferation 1
MTG1 mitochondrial ribosome-associated GTPase 1
MTMR12 myotubularin related protein 12
NDE1 nudE neurodevelopment protein 1
NFE2L3 nuclear factor, erythroid 2-like 3
NT5DC3 5'-nucleotidase domain containing 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
ODF2 outer dense fiber of sperm tails 2
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PARG poly (ADP-ribose) glycohydrolase
PCDHGB5 protocadherin gamma subfamily B, 5
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PHC1 polyhomeotic homolog 1 (Drosophila)
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
POR P450 (cytochrome) oxidoreductase
PRAF2 PRA1 domain family, member 2
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RWDD3 RWD domain containing 3
S1PR4 sphingosine-1-phosphate receptor 4
SCML2 sex comb on midleg-like 2 (Drosophila)
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SIPA1 signal-induced proliferation-associated 1
SLC12A9 solute carrier family 12, member 9
SPON2 spondin 2, extracellular matrix protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STAG3 stromal antigen 3
STBD1 starch binding domain 1
TESK1 testis-specific kinase 1
TET3 tet methylcytosine dioxygenase 3
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TRAF2 TNF receptor-associated factor 2
TUFT1 tuftelin 1
TWISTNB TWIST neighbor
UBE2O ubiquitin-conjugating enzyme E2O
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
YY2 YY2 transcription factor
ZBTB10 zinc finger and BTB domain containing 10
ZHX2 zinc fingers and homeoboxes 2
ZNF493 zinc finger protein 493
ZNF862 zinc finger protein 862