alfadolone-7262 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the alfadolone-7262 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY6 adenylate cyclase 6
AHI1 Abelson helper integration site 1
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APOA1 apolipoprotein A-I
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BRD4 bromodomain containing 4
C21ORF91 chromosome 21 open reading frame 91
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CCDC181 coiled-coil domain containing 181
CCDC85C coiled-coil domain containing 85C
CCPG1 cell cycle progression 1
CENPJ centromere protein J
CIDEB cell death-inducing DFFA-like effector b
CTAGE5 CTAGE family, member 5
CXCL3 chemokine (C-X-C motif) ligand 3
CYLD cylindromatosis (turban tumor syndrome)
DBP D site of albumin promoter (albumin D-box) binding protein
DHRS9 dehydrogenase/reductase (SDR family) member 9
EIF5A2 eukaryotic translation initiation factor 5A2
EWSR1 EWS RNA-binding protein 1
FBN2 fibrillin 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPC3 glypican 3
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRM1 glutamate receptor, metabotropic 1
HDAC7 histone deacetylase 7
HOMER2 homer scaffolding protein 2
HOXA2 homeobox A2
INO80B INO80 complex subunit B
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA0754 KIAA0754
KPNB1 karyopherin (importin) beta 1
KRT34 keratin 34, type I
KYNU kynureninase
LHX2 LIM homeobox 2
LOC647070 uncharacterized LOC647070
LY96 lymphocyte antigen 96
MAP1B microtubule-associated protein 1B
MAP2K5 mitogen-activated protein kinase kinase 5
MPZL2 myelin protein zero-like 2
MRPL44 mitochondrial ribosomal protein L44
MT1E metallothionein 1E
MTSS1L metastasis suppressor 1-like
NABP1 nucleic acid binding protein 1
NF1 neurofibromin 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFX1 nuclear transcription factor, X-box binding 1
NOP16 NOP16 nucleolar protein
NRXN3 neurexin 3
PARP3 poly (ADP-ribose) polymerase family, member 3
PAX2 paired box 2
PBX1 pre-B-cell leukemia homeobox 1
PBX2 pre-B-cell leukemia homeobox 2
PCM1 pericentriolar material 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKNOX1 PBX/knotted 1 homeobox 1
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
RAB28 RAB28, member RAS oncogene family
RNF39 ring finger protein 39
RNFT1 ring finger protein, transmembrane 1
RPL10 ribosomal protein L10
RUNX1-IT1 RUNX1 intronic transcript 1
S100A3 S100 calcium binding protein A3
SCG2 secretogranin II
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD8 SET domain containing (lysine methyltransferase) 8
SH3BP2 SH3-domain binding protein 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STK16 serine/threonine kinase 16
SYNGR1 synaptogyrin 1
TLK1 tousled-like kinase 1
TM4SF1 transmembrane 4 L six family member 1
TMEM242 transmembrane protein 242
TPMT thiopurine S-methyltransferase
TUBB2B tubulin, beta 2B class IIb
WWC1 WW and C2 domain containing 1
ZBTB7A zinc finger and BTB domain containing 7A
ZC3H12A zinc finger CCCH-type containing 12A
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF165 zinc finger protein 165
ZNF253 zinc finger protein 253
ZNF79 zinc finger protein 79

decreased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ACSF2 acyl-CoA synthetase family member 2
ANKFY1 ankyrin repeat and FYVE domain containing 1
APH1B APH1B gamma secretase subunit
ASB7 ankyrin repeat and SOCS box containing 7
AXIN1 axin 1
BAK1 BCL2-antagonist/killer 1
BCAS3 breast carcinoma amplified sequence 3
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BIRC3 baculoviral IAP repeat containing 3
C19ORF54 chromosome 19 open reading frame 54
C5 complement component 5
C9ORF114 chromosome 9 open reading frame 114
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNO cyclin O
CDC37L1 cell division cycle 37-like 1
CENPQ centromere protein Q
CEP72 centrosomal protein 72kDa
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CLSPN claspin
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DCTN4 dynactin 4 (p62)
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EFNA4 ephrin-A4
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
ERCC6 excision repair cross-complementation group 6
ERN2 endoplasmic reticulum to nucleus signaling 2
F8 coagulation factor VIII, procoagulant component
FAM155A family with sequence similarity 155, member A
FAM53B family with sequence similarity 53, member B
FBXO2 F-box protein 2
FBXO46 F-box protein 46
FER fer (fps/fes related) tyrosine kinase
FGD6 FYVE, RhoGEF and PH domain containing 6
GLTP glycolipid transfer protein
GSDMD gasdermin D
GSTT1 glutathione S-transferase theta 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HHLA3 HERV-H LTR-associating 3
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
JUNB jun B proto-oncogene
LMBR1L limb development membrane protein 1-like
LPAR3 lysophosphatidic acid receptor 3
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
MCRS1 microspherule protein 1
MTG1 mitochondrial ribosome-associated GTPase 1
MTRF1 mitochondrial translational release factor 1
MVP major vault protein
NECAP2 NECAP endocytosis associated 2
NPM3 nucleophosmin/nucleoplasmin 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
ODF2 outer dense fiber of sperm tails 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PALMD palmdelphin
PBLD phenazine biosynthesis-like protein domain containing
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PNRC1 proline-rich nuclear receptor coactivator 1
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PUS1 pseudouridylate synthase 1
RAD54L2 RAD54-like 2 (S. cerevisiae)
RBM38 RNA binding motif protein 38
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RNF126P1 ring finger protein 126 pseudogene 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRT2 sirtuin 2
SLC12A8 solute carrier family 12, member 8
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SNIP1 Smad nuclear interacting protein 1
SOBP sine oculis binding protein homolog (Drosophila)
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SYNC syncoilin, intermediate filament protein
TAGLN3 transgelin 3
TCTN2 tectonic family member 2
TIMP2 TIMP metallopeptidase inhibitor 2
TM7SF2 transmembrane 7 superfamily member 2
TMEM132A transmembrane protein 132A
TMEM186 transmembrane protein 186
TMEM62 transmembrane protein 62
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOR4A torsin family 4, member A
TRIM66 tripartite motif containing 66
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TSKU tsukushi, small leucine rich proteoglycan
UEVLD UEV and lactate/malate dehyrogenase domains
ULK1 unc-51 like autophagy activating kinase 1
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
XPC xeroderma pigmentosum, complementation group C
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF212 zinc finger protein 212
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF273 zinc finger protein 273
ZNF813 zinc finger protein 813
ZXDC ZXD family zinc finger C