alfadolone-6506 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the alfadolone-6506 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY10 adenylate cyclase 10 (soluble)
AGMAT agmatine ureohydrolase (agmatinase)
ALDOB aldolase B, fructose-bisphosphate
ARID5A AT rich interactive domain 5A (MRF1-like)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BMP1 bone morphogenetic protein 1
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF40 chromosome 19 open reading frame 40
C1ORF159 chromosome 1 open reading frame 159
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARTPT CART prepropeptide
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CD80 CD80 molecule
CD8A CD8a molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHRM3 cholinergic receptor, muscarinic 3
CLDN17 claudin 17
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CSPP1 centrosome and spindle pole associated protein 1
CYTH1 cytohesin 1
CYTH4 cytohesin 4
DGAT1 diacylglycerol O-acyltransferase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOK4 docking protein 4
DVL3 dishevelled segment polarity protein 3
ELAVL3 ELAV like neuron-specific RNA binding protein 3
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FKRP fukutin related protein
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLUL glutamate-ammonia ligase
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GREB1 growth regulation by estrogen in breast cancer 1
HCAR3 hydroxycarboxylic acid receptor 3
HCRP1 hepatocellular carcinoma-related HCRP1
HES2 hes family bHLH transcription factor 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFT27 intraflagellar transport 27
IGHMBP2 immunoglobulin mu binding protein 2
INSIG1 insulin induced gene 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KRIT1 KRIT1, ankyrin repeat containing
LARP7 La ribonucleoprotein domain family, member 7
LAT2 linker for activation of T cells family, member 2
LDLR low density lipoprotein receptor
LIN7A lin-7 homolog A (C. elegans)
LINC01587 long intergenic non-protein coding RNA 1587
LPIN1 lipin 1
MAX MYC associated factor X
MCOLN1 mucolipin 1
MMP11 matrix metallopeptidase 11
MMP13 matrix metallopeptidase 13
MR1 major histocompatibility complex, class I-related
MX1 MX dynamin-like GTPase 1
NBL1 neuroblastoma 1, DAN family BMP antagonist
NOD2 nucleotide-binding oligomerization domain containing 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
NSUN6 NOP2/Sun domain family, member 6
OPLAH 5-oxoprolinase (ATP-hydrolysing)
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PDE5A phosphodiesterase 5A, cGMP-specific
PIDD1 p53-induced death domain protein 1
PLAUR plasminogen activator, urokinase receptor
PLK3 polo-like kinase 3
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
PTCRA pre T-cell antigen receptor alpha
PTX3 pentraxin 3, long
REM1 RAS (RAD and GEM)-like GTP-binding 1
REPS1 RALBP1 associated Eps domain containing 1
RFPL1 ret finger protein-like 1
RPL35A ribosomal protein L35a
RUNX1 runt-related transcription factor 1
RUSC2 RUN and SH3 domain containing 2
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SETD8 SET domain containing (lysine methyltransferase) 8
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
SRPK2 SRSF protein kinase 2
SRSF1 serine/arginine-rich splicing factor 1
TBC1D19 TBC1 domain family, member 19
TBC1D22B TBC1 domain family, member 22B
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THAP3 THAP domain containing, apoptosis associated protein 3
TLK1 tousled-like kinase 1
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
USB1 U6 snRNA biogenesis 1
ZNF318 zinc finger protein 318
ZNF34 zinc finger protein 34
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
AMPD2 adenosine monophosphate deaminase 2
APLP1 amyloid beta (A4) precursor-like protein 1
APOD apolipoprotein D
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
C5AR2 complement component 5a receptor 2
C8ORF60 chromosome 8 open reading frame 60
C9ORF40 chromosome 9 open reading frame 40
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCDC130 coiled-coil domain containing 130
CCDC69 coiled-coil domain containing 69
CD151 CD151 molecule (Raph blood group)
CDH10 cadherin 10, type 2 (T2-cadherin)
CDK3 cyclin-dependent kinase 3
CDON cell adhesion associated, oncogene regulated
CEL carboxyl ester lipase
CENPJ centromere protein J
CEP85 centrosomal protein 85kDa
CFD complement factor D (adipsin)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLSPN claspin
CNGB3 cyclic nucleotide gated channel beta 3
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRYBG3 beta-gamma crystallin domain containing 3
CST6 cystatin E/M
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DOC2A double C2-like domains, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
F3 coagulation factor III (thromboplastin, tissue factor)
FAM155A family with sequence similarity 155, member A
FGL1 fibrinogen-like 1
FOSL1 FOS-like antigen 1
GATA4 GATA binding protein 4
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H1B histone cluster 1, H1b
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H4A histone cluster 1, H4a
HIST1H4F histone cluster 1, H4f
HOXA4 homeobox A4
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KDM5C lysine (K)-specific demethylase 5C
KDM8 lysine (K)-specific demethylase 8
KIAA0754 KIAA0754
KIFAP3 kinesin-associated protein 3
KLF3 Kruppel-like factor 3 (basic)
KLHL25 kelch-like family member 25
LENEP lens epithelial protein
LOC729164 hCG1732469
LYRM9 LYR motif containing 9
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED15 mediator complex subunit 15
METTL16 methyltransferase like 16
MFAP2 microfibrillar-associated protein 2
MTHFSD methenyltetrahydrofolate synthetase domain containing
NACA2 nascent polypeptide-associated complex alpha subunit 2
NECAP2 NECAP endocytosis associated 2
NIPAL2 NIPA-like domain containing 2
NLGN1 neuroligin 1
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML2A olfactomedin-like 2A
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PADI1 peptidyl arginine deiminase, type I
PCID2 PCI domain containing 2
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLAT plasminogen activator, tissue
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODXL2 podocalyxin-like 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PRF1 perforin 1 (pore forming protein)
PRICKLE3 prickle homolog 3 (Drosophila)
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB27B RAB27B, member RAS oncogene family
RNF126P1 ring finger protein 126 pseudogene 1
SAYSD1 SAYSVFN motif domain containing 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SFT2D2 SFT2 domain containing 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SYNC syncoilin, intermediate filament protein
TCHH trichohyalin
TMC5 transmembrane channel-like 5
TMEM51 transmembrane protein 51
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TSPAN2 tetraspanin 2
TWSG1 twisted gastrulation BMP signaling modulator 1
USP27X ubiquitin specific peptidase 27, X-linked
VLDLR very low density lipoprotein receptor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WWC2 WW and C2 domain containing 2
ZNF394 zinc finger protein 394
ZNF446 zinc finger protein 446