alcohol dependence Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

320 genes co-occuring with the disease alcohol dependence in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.56721
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2.40054
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 2.24577
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2.13921
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.06171
DRD2 dopamine receptor D2 2.02658
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 1.99826
OPRM1 opioid receptor, mu 1 1.88805
GGT1 gamma-glutamyltransferase 1 1.83228
ANKK1 ankyrin repeat and kinase domain containing 1 1.82685
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 1.68181
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.6534
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.64891
ADH6 alcohol dehydrogenase 6 (class V) 1.63052
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 1.62247
CHRM2 cholinergic receptor, muscarinic 2 1.54054
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.47198
DRD4 dopamine receptor D4 1.45133
NKAIN1 Na+/K+ transporting ATPase interacting 1 1.44035
OPRD1 opioid receptor, delta 1 1.43947
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.38123
OPRK1 opioid receptor, kappa 1 1.37774
CRH corticotropin releasing hormone 1.36684
TF transferrin 1.34722
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 1.33458
NPY neuropeptide Y 1.31231
FGD1 FYVE, RhoGEF and PH domain containing 1 1.30751
GGT2 gamma-glutamyltransferase 2 1.30139
PHF3 PHD finger protein 3 1.30139
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 1.29352
GRIK3 glutamate receptor, ionotropic, kainate 3 1.28654
MAOA monoamine oxidase A 1.24515
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 1.24211
SERINC2 serine incorporator 2 1.23299
DRD1 dopamine receptor D1 1.23256
PDYN prodynorphin 1.19618
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 1.19618
PCNX pecanex homolog (Drosophila) 1.19014
CRHR1 corticotropin releasing hormone receptor 1 1.18712
CNR1 cannabinoid receptor 1 (brain) 1.17121
ANKRD7 ankyrin repeat domain 7 1.16692
FSIP2 fibrous sheath interacting protein 2 1.16692
TESK2 testis-specific kinase 2 1.16692
OR51L1 olfactory receptor, family 51, subfamily L, member 1 1.16692
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.16606
TAS2R16 taste receptor, type 2, member 16 1.15922
BDNF brain-derived neurotrophic factor 1.14857
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 1.14051
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.12445
GHRL ghrelin/obestatin prepropeptide 1.12108
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 1.1194
POMC proopiomelanocortin 1.11519
DRD3 dopamine receptor D3 1.10468
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.07404
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.06648
TPH2 tryptophan hydroxylase 2 1.06606
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.0627
C1QTNF7 C1q and tumor necrosis factor related protein 7 1.05765
MTIF2 mitochondrial translational initiation factor 2 1.05765
TTC12 tetratricopeptide repeat domain 12 1.0463
COMT catechol-O-methyltransferase 1.04167
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 1.03872
NRD1 nardilysin (N-arginine dibasic convertase) 1.02271
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.02229
TPH1 tryptophan hydroxylase 1 1.01849
MAOB monoamine oxidase B 1.01849
IPO11 importin 11 1.01427
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.00161
PKNOX2 PBX/knotted 1 homeobox 2 1.00119
CASC4 cancer susceptibility candidate 4 0.994439
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.96918
CCDC63 coiled-coil domain containing 63 0.963309
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.960797
C15ORF53 chromosome 15 open reading frame 53 0.924626
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 0.912257
GRM3 glutamate receptor, metabotropic 3 0.906498
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 0.888848
SRRD SRR1 domain containing 0.882701
ARID5A AT rich interactive domain 5A (MRF1-like) 0.879424
GRIK1 glutamate receptor, ionotropic, kainate 1 0.874919
DTWD2 DTW domain containing 2 0.870825
TMEM108 transmembrane protein 108 0.870825
PNOC prepronociceptin 0.866731
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.862637
THSD7B thrombospondin, type I, domain containing 7B 0.858543
GRM7 glutamate receptor, metabotropic 7 0.856905
C15ORF32 chromosome 15 open reading frame 32 0.843392
OSBPL5 oxysterol binding protein-like 5 0.840934
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.835198
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.833148
ADCY2 adenylate cyclase 2 (brain) 0.820026
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.808129
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.806898
UBAP2 ubiquitin associated protein 2 0.801974
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.799513
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.792951
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.786394
TAGLN3 transgelin 3 0.779432
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.778613
NPY2R neuropeptide Y receptor Y2 0.77575
ASTN1 astrotactin 1 0.772887
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.768393
MAMSTR MEF2 activating motif and SAP domain containing transcriptional regulator 0.761454
ZCCHC14 zinc finger, CCHC domain containing 14 0.758601
MANEA mannosidase, endo-alpha 0.757786
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.75412
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.744766
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 0.738271
STON2 stonin 2 0.735838
DSCAML1 Down syndrome cell adhesion molecule like 1 0.730976
OPN3 opsin 3 0.730571
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 0.720865
TAS2R38 taste receptor, type 2, member 38 0.719654
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.71925
GHSR growth hormone secretagogue receptor 0.709975
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 0.708364
TACR1 tachykinin receptor 1 0.69751
PECR peroxisomal trans-2-enoyl-CoA reductase 0.695103
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) 0.693098
DCXR dicarbonyl/L-xylulose reductase 0.690293
ARC activity-regulated cytoskeleton-associated protein 0.682693
ABLIM1 actin binding LIM protein 1 0.678302
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.67113
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.670732
KLF11 Kruppel-like factor 11 0.666358
GLRA3 glycine receptor, alpha 3 0.665563
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.664372
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.664372
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 0.661594
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.657234
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.656046
GRM8 glutamate receptor, metabotropic 8 0.643404
THEMIS thymocyte selection associated 0.637889
AUTS2 autism susceptibility candidate 2 0.629635
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.628457
GPR55 G protein-coupled receptor 55 0.628065
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.628065
ADRA2A adrenoceptor alpha 2A 0.624535
ADCY7 adenylate cyclase 7 0.619051
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.617486
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.613574
CRHBP corticotropin releasing hormone binding protein 0.610838
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.610838
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 0.606933
EYS eyes shut homolog (Drosophila) 0.606543
ARL15 ADP-ribosylation factor-like 15 0.60225
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.59991
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.596012
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.595233
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.593674
CSMD2 CUB and Sushi multiple domains 2 0.590558
RFX4 regulatory factor X, 4 (influences HLA class II expression) 0.590558
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.590169
LEP leptin 0.589779
MREG melanoregulin 0.589001
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.582773
AGPS alkylglycerone phosphate synthase 0.576939
GRID1 glutamate receptor, ionotropic, delta 1 0.574217
MEA1 male-enhanced antigen 1 0.572662
ANAPC1 anaphase promoting complex subunit 1 0.569552
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.565666
NAP1L4 nucleosome assembly protein 1-like 4 0.562169
PENK proenkephalin 0.559839
LVRN laeverin 0.558674
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.550911
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) 0.549359
GABRR1 gamma-aminobutyric acid (GABA) A receptor, rho 1 0.542379
TNN tenascin N 0.540442
CREB1 cAMP responsive element binding protein 1 0.536957
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 0.536183
UNC79 unc-79 homolog (C. elegans) 0.532701
ZNF699 zinc finger protein 699 0.532314
KPNA3 karyopherin alpha 3 (importin alpha 4) 0.528835
PDE10A phosphodiesterase 10A 0.522273
FTO fat mass and obesity associated 0.520346
DNASE2B deoxyribonuclease II beta 0.513417
PLCL1 phospholipase C-like 1 0.509959
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.509192
MGLL monoglyceride lipase 0.503824
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.501527
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.501527
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 0.499231
CINP cyclin-dependent kinase 2 interacting protein 0.496939
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.49274
HOMER2 homer scaffolding protein 2 0.489311
PRL prolactin 0.482084
PRKG2 protein kinase, cGMP-dependent, type II 0.479047
NALCN sodium leak channel, non selective 0.477151
DUSP8 dual specificity phosphatase 8 0.472982
GATA4 GATA binding protein 4 0.468819
FAAH fatty acid amide hydrolase 0.456732
DRD5 dopamine receptor D5 0.453716
NPS neuropeptide S 0.453339
HRH3 histamine receptor H3 0.452208
TRH thyrotropin-releasing hormone 0.452208
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.451078
HES2 hes family bHLH transcription factor 2 0.445429
SGCE sarcoglycan, epsilon 0.443171
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 0.441666
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.440162
RGS19 regulator of G-protein signaling 19 0.439786
LARS leucyl-tRNA synthetase 0.43753
MARK1 MAP/microtubule affinity-regulating kinase 1 0.436402
ADCY8 adenylate cyclase 8 (brain) 0.435275
GPD1L glycerol-3-phosphate dehydrogenase 1-like 0.433397
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.433021
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 0.432646
C19ORF26 chromosome 19 open reading frame 26 0.426265
GLUD2 glutamate dehydrogenase 2 0.42289
GAGE12F G antigen 12F 0.42139
OPRL1 opiate receptor-like 1 0.419142
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.415024
FGD4 FYVE, RhoGEF and PH domain containing 4 0.415024
KDM4C lysine (K)-specific demethylase 4C 0.41465
NEUROD2 neuronal differentiation 2 0.414276
CCKBR cholecystokinin B receptor 0.412031
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.410535
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.409787
GAL galanin/GMAP prepropeptide 0.407919
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.404931
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.398589
TH tyrosine hydroxylase 0.391513
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.390397
HYLS1 hydrolethalus syndrome 1 0.378143
NPY5R neuropeptide Y receptor Y5 0.377773
INADL InaD-like (Drosophila) 0.377031
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 0.373698
GRM2 glutamate receptor, metabotropic 2 0.373328
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.372587
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.372587
CRHR2 corticotropin releasing hormone receptor 2 0.369997
EFNA5 ephrin-A5 0.369628
SYNE1 spectrin repeat containing, nuclear envelope 1 0.367779
KANK1 KN motif and ankyrin repeat domains 1 0.365562
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.364824
CCDC88A coiled-coil domain containing 88A 0.363347
SALL2 spalt-like transcription factor 2 0.357814
GALR3 galanin receptor 3 0.355604
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 0.355604
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) 0.354131
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.353395
UCN3 urocortin 3 0.353027
TFIP11 tuftelin interacting protein 11 0.353027
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.347144
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 0.345308
SLC19A3 solute carrier family 19 (thiamine transporter), member 3 0.340173
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 0.331025
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.32701
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.325916
PDLIM5 PDZ and LIM domain 5 0.324094
OR10R2 olfactory receptor, family 10, subfamily R, member 2 0.316819
NLGN4X neuroligin 4, X-linked 0.313189
DACT3 dishevelled-binding antagonist of beta-catenin 3 0.312827
CCKAR cholecystokinin A receptor 0.304503
AKAP9 A kinase (PRKA) anchor protein 9 0.302698
NRXN3 neurexin 3 0.302337
AKR1C3 aldo-keto reductase family 1, member C3 0.300173
NGF nerve growth factor (beta polypeptide) 0.300173
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.299452
RXRB retinoid X receptor, beta 0.299092
ITGAD integrin, alpha D 0.296211
RNF19B ring finger protein 19B 0.295851
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.295492
CNOT2 CCR4-NOT transcription complex, subunit 2 0.295132
NPPA natriuretic peptide A 0.295132
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.295132
ACSL4 acyl-CoA synthetase long-chain family member 4 0.294772
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.287593
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.28616
CNTN4 contactin 4 0.283655
CNTN6 contactin 6 0.274021
MAP6 microtubule-associated protein 6 0.268687
FBXO2 F-box protein 2 0.268332
GRM1 glutamate receptor, metabotropic 1 0.267977
TOR1A torsin family 1, member A (torsin A) 0.267977
TAC1 tachykinin, precursor 1 0.260184
NCAM1 neural cell adhesion molecule 1 0.25983
NFYA nuclear transcription factor Y, alpha 0.255241
CYTL1 cytokine-like 1 0.252774
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.250663
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.245396
CNR2 cannabinoid receptor 2 (macrophage) 0.244696
SKI SKI proto-oncogene 0.244345
NPY1R neuropeptide Y receptor Y1 0.237009
PNPLA3 patatin-like phospholipase domain containing 3 0.23492
CDH13 cadherin 13 0.231102
GALR1 galanin receptor 1 0.230755
TAC3 tachykinin 3 0.212271
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.207578
LTBP1 latent transforming growth factor beta binding protein 1 0.20658
ALLC allantoicase 0.204923
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.199681
ADCY1 adenylate cyclase 1 (brain) 0.199356
GALR2 galanin receptor 2 0.198064
FOS FBJ murine osteosarcoma viral oncogene homolog 0.197742
ADCY3 adenylate cyclase 3 0.197742
CHRM1 cholinergic receptor, muscarinic 1 0.19582
PER2 period circadian clock 2 0.192971
BPI bactericidal/permeability-increasing protein 0.191097
THAP1 THAP domain containing, apoptosis associated protein 1 0.189551
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.189551
AVP arginine vasopressin 0.188326
LATS1 large tumor suppressor kinase 1 0.185016
LMO1 LIM domain only 1 (rhombotin 1) 0.184128
GRIK4 glutamate receptor, ionotropic, kainate 4 0.181798
GAGE12I G antigen 12I 0.180084
ALYREF Aly/REF export factor 0.180084
SKP1 S-phase kinase-associated protein 1 0.178403
GRM5 glutamate receptor, metabotropic 5 0.177029
HOMER1 homer scaffolding protein 1 0.174354
CD4 CD4 molecule 0.172799
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 0.172799
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 0.172291
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) 0.164786
C1QBP complement component 1, q subcomponent binding protein 0.162908
SOS1 son of sevenless homolog 1 (Drosophila) 0.161139
TACR3 tachykinin receptor 3 0.160948
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.160387
HIP1 huntingtin interacting protein 1 0.158951
ADCY5 adenylate cyclase 5 0.157765