alcohol abuse Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (Human Disease Ontology, DOID_1574)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:1574
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Genes

178 genes associated with the disease alcohol abuse in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 3.56068
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 3.5448
CCDC63 coiled-coil domain containing 63 3.15529
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 2.72317
GGT1 gamma-glutamyltransferase 1 2.58931
TF transferrin 2.47655
BRAP BRCA1 associated protein 2.3238
HFE hemochromatosis 2.31188
HNF1A HNF1 homeobox A 2.26279
SRPRB signal recognition particle receptor, B subunit 2.24446
MYL2 myosin, light chain 2, regulatory, cardiac, slow 2.10991
RAB6B RAB6B, member RAS oncogene family 2.03247
MYLK myosin light chain kinase 1.92971
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 1.89195
CUX2 cut-like homeobox 2 1.83673
ZNF827 zinc finger protein 827 1.78856
C12ORF43 chromosome 12 open reading frame 43 1.75331
EXOC3L4 exocyst complex component 3-like 4 1.7088
FLT1 fms-related tyrosine kinase 1 1.69536
OASL 2'-5'-oligoadenylate synthetase-like 1.68731
ADD1 adducin 1 (alpha) 1.67673
CCDC14 coiled-coil domain containing 14 1.66846
JPH1 junctophilin 1 1.66297
LPP LIM domain containing preferred translocation partner in lipoma 1.63244
PARP2 poly (ADP-ribose) polymerase 2 1.63039
CCDC91 coiled-coil domain containing 91 1.55024
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 1.54156
PGM1 phosphoglucomutase 1 1.48206
TOPBP1 topoisomerase (DNA) II binding protein 1 1.42026
RORA RAR-related orphan receptor A 1.39396
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.39396
AUTS2 autism susceptibility candidate 2 1.35834
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 1.28289
LMO1 LIM domain only 1 (rhombotin 1) 1.21996
IYD iodotyrosine deiodinase 1.17391
HNF4A hepatocyte nuclear factor 4, alpha 1.16174
PTP4A2 protein tyrosine phosphatase type IVA, member 2 1.14545
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.14463
LOC283299 uncharacterized LOC283299 1.1337
CORO2A coronin, actin binding protein, 2A 1.11123
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 1.08467
RPH3A rabphilin 3A 1.079
LINC00578 long intergenic non-protein coding RNA 578 1.07599
PLCL1 phospholipase C-like 1 1.07599
TLR1 toll-like receptor 1 1.07336
TRPM1 transient receptor potential cation channel, subfamily M, member 1 1.06224
LOC100505718 1.05657
ESRRG estrogen-related receptor gamma 1.00407
BDKRB2 bradykinin receptor B2 0.996561
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.986048
ABHD17C abhydrolase domain containing 17C 0.976976
SLC26A4 solute carrier family 26 (anion exchanger), member 4 0.971169
EXOC5 exocyst complex component 5 0.971169
ASTN2 astrotactin 2 0.959568
CLUAP1 clusterin associated protein 1 0.958374
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast) 0.945129
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3 0.941109
GPR12 G protein-coupled receptor 12 0.935465
ZNF503-AS1 ZNF503 antisense RNA 1 0.93456
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.925987
SH3GL3 SH3-domain GRB2-like 3 0.915252
C14ORF132 chromosome 14 open reading frame 132 0.914528
MYO16 myosin XVI 0.911472
PHACTR3 phosphatase and actin regulator 3 0.907073
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.904255
MIR100HG mir-100-let-7a-2 cluster host gene 0.898225
MOB3B MOB kinase activator 3B 0.884
PLXNA4 plexin A4 0.879744
TSHB thyroid stimulating hormone, beta 0.875106
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.869084
CDH13 cadherin 13 0.868556
TMEM156 transmembrane protein 156 0.858397
RPAP2 RNA polymerase II associated protein 2 0.858397
VAT1 vesicle amine transport 1 0.856323
GLMN glomulin, FKBP associated protein 0.851812
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 0.851323
CNTN4 contactin 4 0.847035
OSBPL6 oxysterol binding protein-like 6 0.842041
ZNF224 zinc finger protein 224 0.842041
TSHZ2 teashirt zinc finger homeobox 2 0.84116
LARGE like-glycosyltransferase 0.839855
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.836877
SNX16 sorting nexin 16 0.831584
C1ORF146 chromosome 1 open reading frame 146 0.831182
EVI5 ecotropic viral integration site 5 0.830304
ZNF623 zinc finger protein 623 0.820721
ZC3H7A zinc finger CCCH-type containing 7A 0.818364
ANO3 anoctamin 3 0.817977
FASTKD1 FAST kinase domains 1 0.813813
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.813443
DTX1 deltex 1, E3 ubiquitin ligase 0.811614
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 0.811614
GTF2IRD1 GTF2I repeat domain containing 1 0.807706
KANK1 KN motif and ankyrin repeat domains 1 0.801631
UST uronyl-2-sulfotransferase 0.792881
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.792881
RIMBP2 RIMS binding protein 2 0.792543
CEMIP cell migration inducing protein, hyaluronan binding 0.788564
PEX5L peroxisomal biogenesis factor 5-like 0.777184
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 0.775452
LOC100422737 uncharacterized LOC100422737 0.769887
PARD3B par-3 family cell polarity regulator beta 0.760414
CSMD1 CUB and Sushi multiple domains 1 0.759585
GRB10 growth factor receptor-bound protein 10 0.752915
GDA guanine deaminase 0.748112
LHFP lipoma HMGIC fusion partner 0.748112
MGAM maltase-glucoamylase 0.746884
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.745188
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.744948
CARD8 caspase recruitment domain family, member 8 0.737547
SCLY selenocysteine lyase 0.735265
UBE2F-SCLY UBE2F-SCLY readthrough (NMD candidate) 0.735265
CACHD1 cache domain containing 1 0.728674
ZNF284 zinc finger protein 284 0.727764
ZNF225 zinc finger protein 225 0.724637
FAM69A family with sequence similarity 69, member A 0.719267
COX7B2 cytochrome c oxidase subunit VIIb2 0.719267
TSPAN2 tetraspanin 2 0.71864
SIK3 SIK family kinase 3 0.717397
IGF1 insulin-like growth factor 1 (somatomedin C) 0.716372
OXR1 oxidation resistance 1 0.715762
SMAD7 SMAD family member 7 0.715559
RPL5 ribosomal protein L5 0.708698
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.699619
MASTL microtubule associated serine/threonine kinase-like 0.696378
ZNF609 zinc finger protein 609 0.693234
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.692261
LOC100379224 uncharacterized LOC100379224 0.686305
SYK spleen tyrosine kinase 0.683009
PTPRK protein tyrosine phosphatase, receptor type, K 0.680391
SYCP1 synaptonemal complex protein 1 0.680391
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 0.670567
ESPNL espin-like 0.668936
TRRAP transformation/transcription domain-associated protein 0.668836
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.666845
DOCK6 dedicator of cytokinesis 6 0.647016
UBE2F ubiquitin-conjugating enzyme E2F (putative) 0.642594
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.633226
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.623422
PHACTR2 phosphatase and actin regulator 2 0.616424
OSBPL3 oxysterol binding protein-like 3 0.615118
FHIT fragile histidine triad 0.615118
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.615118
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.615118
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 0.615118
EMC2 ER membrane protein complex subunit 2 0.615118
VAT1L vesicle amine transport 1-like 0.614766
PLA2G4D phospholipase A2, group IVD (cytosolic) 0.609075
ATXN2 ataxin 2 0.608439
MYO1H myosin IH 0.59964
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.588801
ZNF221 zinc finger protein 221 0.586345
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.586345
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.574821
ANXA2 annexin A2 0.564734
MCC mutated in colorectal cancers 0.564734
ZDHHC6 zinc finger, DHHC-type containing 6 0.564734
FAM107B family with sequence similarity 107, member B 0.564734
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.564734
MSH6 mutS homolog 6 0.547225
MLXIPL MLX interacting protein-like 0.547225
HNF1B HNF1 homeobox B 0.547225
LHX6 LIM homeobox 6 0.547225
MED15 mediator complex subunit 15 0.547225
ZNF214 zinc finger protein 214 0.532547
LINC00189 long intergenic non-protein coding RNA 189 0.529547
TRAF4 TNF receptor-associated factor 4 0.520364
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.520364
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.520364
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.520364
TRPV4 transient receptor potential cation channel, subfamily V, member 4 0.511996
SEPT9 septin 9 0.511996
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.510061
ZHX2 zinc fingers and homeoboxes 2 0.505894
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.502485
NOD2 nucleotide-binding oligomerization domain containing 2 0.502485
FCHO1 FCH domain only 1 0.502485
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.502485