alcohol abuse Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (Human Disease Ontology, DOID_1574)
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Genes

31 genes associated with the disease alcohol abuse in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
CAT catalase
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GSTM1 glutathione S-transferase mu 1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
MAOA monoamine oxidase A
NPY neuropeptide Y
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
OPRM1 opioid receptor, mu 1
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
TNF tumor necrosis factor
TPH1 tryptophan hydroxylase 1