alcohol abuse Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (Human Disease Ontology, DOID_1574)
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Genes

278 genes co-occuring with the disease alcohol abuse in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TF transferrin 2.21271
GGT1 gamma-glutamyltransferase 1 2.19084
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.68408
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 1.62873
GGT2 gamma-glutamyltransferase 2 1.61083
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.57913
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.51809
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.49789
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 1.42279
DRD2 dopamine receptor D2 1.2595
IQUB IQ motif and ubiquitin domain containing 1.06816
PLSCR5 phospholipid scramblase family, member 5 1.06816
CD4 CD4 molecule 1.0071
AFP alpha-fetoprotein 0.939119
UROD uroporphyrinogen decarboxylase 0.930414
ALB albumin 0.916375
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.880243
CRH corticotropin releasing hormone 0.878605
CAT catalase 0.856905
ALPPL2 alkaline phosphatase, placental-like 2 0.849536
ALPP alkaline phosphatase, placental 0.849126
ALPL alkaline phosphatase, liver/bone/kidney 0.848716
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.845031
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.833968
PNOC prepronociceptin 0.820847
POMC proopiomelanocortin 0.812642
DRD4 dopamine receptor D4 0.81018
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 0.808129
UBL3 ubiquitin-like 3 0.806077
INS insulin 0.801974
TNF tumor necrosis factor 0.783526
FTH1 ferritin, heavy polypeptide 1 0.781888
FTL ferritin, light polypeptide 0.781888
CTRC chymotrypsin C (caldecrin) 0.775341
CNR1 cannabinoid receptor 1 (brain) 0.774114
F2 coagulation factor II (thrombin) 0.74883
TLR4 toll-like receptor 4 0.748017
NCALD neurocalcin delta 0.745578
PRSS30P protease, serine, 30, pseudogene 0.726929
PRSS1 protease, serine, 1 (trypsin 1) 0.725311
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.724098
GLUD2 glutamate dehydrogenase 2 0.72127
PTH parathyroid hormone 0.718443
C19ORF26 chromosome 19 open reading frame 26 0.706754
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.703938
UCN3 urocortin 3 0.692697
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H 0.692296
CCK cholecystokinin 0.689893
NPY neuropeptide Y 0.683493
CORT cortistatin 0.668742
ARHGAP42 Rho GTPase activating protein 42 0.658422
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.656441
NPY5R neuropeptide Y receptor Y5 0.654463
ARHGAP10 Rho GTPase activating protein 10 0.653671
GALR3 galanin receptor 3 0.648928
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal) 0.644586
SPINK1 serine peptidase inhibitor, Kazal type 1 0.635135
CD79A CD79a molecule, immunoglobulin-associated alpha 0.626495
GOLGB1 golgin B1 0.615138
MAN1A1 mannosidase, alpha, class 1A, member 1 0.613574
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 0.613183
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.611229
HFE hemochromatosis 0.609666
IGF1 insulin-like growth factor 1 (somatomedin C) 0.608494
SCAP SREBF chaperone 0.60342
GAL galanin/GMAP prepropeptide 0.592895
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.584719
MAOA monoamine oxidase A 0.579661
BGLAP bone gamma-carboxyglutamate (gla) protein 0.571107
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C 0.55945
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.55945
BDNF brain-derived neurotrophic factor 0.553239
CAGE1 cancer antigen 1 0.551298
OPRM1 opioid receptor, mu 1 0.548583
GPX5 glutathione peroxidase 5 0.541992
GPX4 glutathione peroxidase 4 0.538506
OPRL1 opiate receptor-like 1 0.537344
SOD2 superoxide dismutase 2, mitochondrial 0.535409
GRM7 glutamate receptor, metabotropic 7 0.533475
GPX1 glutathione peroxidase 1 0.523045
APLF aprataxin and PNKP like factor 0.521888
CRHR1 corticotropin releasing hormone receptor 1 0.514571
ACE angiotensin I converting enzyme 0.513033
DRD1 dopamine receptor D1 0.510344
CREB1 cAMP responsive element binding protein 1 0.507657
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 0.504207
ANKRD23 ankyrin repeat domain 23 0.494648
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.491978
PRL prolactin 0.484364
TKT transketolase 0.483604
TBK1 TANK-binding kinase 1 0.47753
JMJD1C jumonji domain containing 1C 0.476772
MYDGF myeloid-derived growth factor 0.473361
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.469197
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 0.461261
BPI bactericidal/permeability-increasing protein 0.459373
CTSB cathepsin B 0.454093
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.453339
FBXO32 F-box protein 32 0.452962
MAOB monoamine oxidase B 0.452585
TGFB1 transforming growth factor, beta 1 0.449571
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.446558
APOB apolipoprotein B 0.444676
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.4443
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.442795
DRD3 dopamine receptor D3 0.43941
UCN urocortin 0.439034
PDCD6IP programmed cell death 6 interacting protein 0.43753
IFNL3 interferon, lambda 3 0.427765
RORB RAR-related orphan receptor B 0.42364
ANKK1 ankyrin repeat and kinase domain containing 1 0.42289
IL6 interleukin 6 0.418394
GRM3 glutamate receptor, metabotropic 3 0.41727
HEXB hexosaminidase B (beta polypeptide) 0.414276
OTP orthopedia homeobox 0.413153
TLN2 talin 2 0.412779
MESDC2 mesoderm development candidate 2 0.407919
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.406798
TXN2 thioredoxin 2 0.404184
HOMER2 homer scaffolding protein 2 0.400826
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.399707
LEP leptin 0.39598
SHBG sex hormone-binding globulin 0.395608
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.394491
ALAD aminolevulinate dehydratase 0.391885
FGD1 FYVE, RhoGEF and PH domain containing 1 0.387794
GRIK3 glutamate receptor, ionotropic, kainate 3 0.385936
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.384079
MC3R melanocortin 3 receptor 0.380739
GSTA3 glutathione S-transferase alpha 3 0.374068
GSTA2 glutathione S-transferase alpha 2 0.372958
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.372587
FOS FBJ murine osteosarcoma viral oncogene homolog 0.371847
GSTA4 glutathione S-transferase alpha 4 0.371847
DRD5 dopamine receptor D5 0.365932
GSTA1 glutathione S-transferase alpha 1 0.365932
TP53 tumor protein p53 0.363347
PNPLA3 patatin-like phospholipase domain containing 3 0.362978
IPO8 importin 8 0.359657
AOX1 aldehyde oxidase 1 0.355972
CRP C-reactive protein, pentraxin-related 0.354868
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 0.353027
PARP9 poly (ADP-ribose) polymerase family, member 9 0.351555
SOX3 SRY (sex determining region Y)-box 3 0.351555
SH3RF1 SH3 domain containing ring finger 1 0.350452
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.347511
HCRT hypocretin (orexin) neuropeptide precursor 0.346042
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.346042
TRAPPC10 trafficking protein particle complex 10 0.345308
PDYN prodynorphin 0.344207
LPL lipoprotein lipase 0.34384
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 0.342739
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 0.342739
FGGY FGGY carbohydrate kinase domain containing 0.337608
GLRX2 glutaredoxin 2 0.336876
EGOT eosinophil granule ontogeny transcript (non-protein coding) 0.336876
IL1B interleukin 1, beta 0.33651
RGS7 regulator of G-protein signaling 7 0.335046
GLDN gliomedin 0.332852
OCLN occludin 0.33066
NRD1 nardilysin (N-arginine dibasic convertase) 0.329565
HESX1 HESX homeobox 1 0.328469
REG1A regenerating islet-derived 1 alpha 0.328469
TKFC triokinase/FMN cyclase 0.327375
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2 0.324458
AVEN apoptosis, caspase activation inhibitor 0.32373
CSH2 chorionic somatomammotropin hormone 2 0.323365
LMO3 LIM domain only 3 (rhombotin-like 2) 0.323365
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.321181
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.319363
VRK2 vaccinia related kinase 2 0.317545
ADAR adenosine deaminase, RNA-specific 0.316456
LIPE lipase, hormone-sensitive 0.309204
COMT catechol-O-methyltransferase 0.306672
MB myoglobin 0.304503
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.304142
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 0.304142
GSR glutathione reductase 0.302337
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.301254
PER1 period circadian clock 1 0.300173
HBA2 hemoglobin, alpha 2 0.295132
UGT8 UDP glycosyltransferase 8 0.294772
NPS neuropeptide S 0.294053
KMT2A lysine (K)-specific methyltransferase 2A 0.29118
MMP8 matrix metallopeptidase 8 0.289744
APOA2 apolipoprotein A-II 0.289027
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.287235
ADH6 alcohol dehydrogenase 6 (class V) 0.283655
CCDC130 coiled-coil domain containing 130 0.280082
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 0.277584
NOX3 NADPH oxidase 3 0.27687
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.275801
KIN Kin17 DNA and RNA binding protein 0.275801
PMM2 phosphomannomutase 2 0.274021
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.27153
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 0.270464
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.268332
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 0.26266
CEL carboxyl ester lipase 0.26266
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 0.261952
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 0.260891
UNC13A unc-13 homolog A (C. elegans) 0.257358
ALLC allantoicase 0.254536
STX10 syntaxin 10 0.248203
PPARA peroxisome proliferator-activated receptor alpha 0.247852
PDLIM5 PDZ and LIM domain 5 0.240497
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.23945
GRIP1 glutamate receptor interacting protein 1 0.239101
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.23666
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.235616
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.231795
IRS4 insulin receptor substrate 4 0.224884
FOXJ2 forkhead box J2 0.223853
TRH thyrotropin-releasing hormone 0.222136
TJP1 tight junction protein 1 0.220081
GSTM2 glutathione S-transferase mu 2 (muscle) 0.216672
ARNTL aryl hydrocarbon receptor nuclear translocator-like 0.212945
COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein 0.211261
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.210589
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.209583
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.208579
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.207245
HBA1 hemoglobin, alpha 1 0.206913
CCKAR cholecystokinin A receptor 0.206913
KLF11 Kruppel-like factor 11 0.204593
STX1B syntaxin 1B 0.204263
PRAC1 prostate cancer susceptibility candidate 1 0.203604
BHLHE22 basic helix-loop-helix family, member e22 0.202946
GRM2 glutamate receptor, metabotropic 2 0.202618
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.198709
PRRC2A proline-rich coiled-coil 2A 0.198064
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.197742
MEF2C myocyte enhancer factor 2C 0.196779
TCF21 transcription factor 21 0.196139
DNAH8 dynein, axonemal, heavy chain 8 0.193285
CARTPT CART prepropeptide 0.191719
CHAT choline O-acetyltransferase 0.190786
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.190168
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.190168
AUTS2 autism susceptibility candidate 2 0.189244
C3 complement component 3 0.188022
SAA4 serum amyloid A4, constitutive 0.18591
FOXH1 forkhead box H1 0.185313
MLXIPL MLX interacting protein-like 0.18472
LPA lipoprotein, Lp(a) 0.18472
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.183248
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.182957
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.181798
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase 0.181798
IL10 interleukin 10 0.17896
PLIN3 perilipin 3 0.178126
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 0.178126
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.177301
TTK TTK protein kinase 0.176757
PAM peptidylglycine alpha-amidating monooxygenase 0.176485
IFNA1 interferon, alpha 1 0.176485
MMP2 matrix metallopeptidase 2 0.174093
UGP2 UDP-glucose pyrophosphorylase 2 0.173571
HES2 hes family bHLH transcription factor 2 0.172799
DGAT2 diacylglycerol O-acyltransferase 2 0.171785
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 0.170544
RPLP0 ribosomal protein, large, P0 0.167915
GRB2 growth factor receptor-bound protein 2 0.167452
HRAS Harvey rat sarcoma viral oncogene homolog 0.167224
PPT1 palmitoyl-protein thioesterase 1 0.166544
RNPEP arginyl aminopeptidase (aminopeptidase B) 0.164571
TARBP2 TAR (HIV-1) RNA binding protein 2 0.163729
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 0.163523
BIN2 bridging integrator 2 0.163317
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.162109
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.161139
HAMP hepcidin antimicrobial peptide 0.160948
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.160203
HP haptoglobin 0.160021
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.15948
CPB1 carboxypeptidase B1 (tissue) 0.158951
ADCY2 adenylate cyclase 2 (brain) 0.158434
TET1 tet methylcytosine dioxygenase 1 0.157765