age related macular degeneration Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. (Human Disease Ontology, DOID_10871)
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Genes

354 genes co-occuring with the disease age related macular degeneration in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CFH complement factor H 3.05687
HTRA1 HtrA serine peptidase 1 2.50017
VEGFA vascular endothelial growth factor A 2.3675
CFB complement factor B 2.11827
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.10663
C2 complement component 2 1.79706
HMCN1 hemicentin 1 1.70451
CFHR3 complement factor H-related 3 1.69542
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 1.67367
CFHR1 complement factor H-related 1 1.62694
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 1.61754
TIMP3 TIMP metallopeptidase inhibitor 3 1.60234
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.59966
C3 complement component 3 1.49789
RHO rhodopsin 1.45485
RPE65 retinal pigment epithelium-specific protein 65kDa 1.45485
RAP2A RAP2A, member of RAS oncogene family 1.26821
LIPC lipase, hepatic 1.26734
CFI complement factor I 1.22432
FLT1 fms-related tyrosine kinase 1 1.20829
PLAT plasminogen activator, tissue 1.20656
ELOVL4 ELOVL fatty acid elongase 4 1.20093
APOE apolipoprotein E 1.18238
CCL2 chemokine (C-C motif) ligand 2 1.18023
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 1.15965
HEPH hephaestin 1.15325
BEST1 bestrophin 1 1.14305
FBLN5 fibulin 5 1.14051
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.13374
AGBL4 ATP/GTP binding protein-like 4 1.12867
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 1.12361
CFHR4 complement factor H-related 4 1.12361
NOA1 nitric oxide associated 1 1.10468
RDH8 retinol dehydrogenase 8 (all-trans) 1.10258
VEGFB vascular endothelial growth factor B 1.08118
CD46 CD46 molecule, complement regulatory protein 1.07782
COL18A1 collagen, type XVIII, alpha 1 1.06942
SEBOX SEBOX homeobox 1.05807
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.02018
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.986849
CCR2 chemokine (C-C motif) receptor 2 0.974221
NELFE negative elongation factor complex member E 0.965405
RLBP1 retinaldehyde binding protein 1 0.942858
KDR kinase insert domain receptor 0.942027
MMP2 matrix metallopeptidase 2 0.939119
PGF placental growth factor 0.93
SOD2 superoxide dismutase 2, mitochondrial 0.924626
CFHR2 complement factor H-related 2 0.922149
TLR3 toll-like receptor 3 0.909787
RING1 ring finger protein 1 0.904854
CFHR5 complement factor H-related 5 0.901567
FGF2 fibroblast growth factor 2 (basic) 0.88475
TRAPPC6B trafficking protein particle complex 6B 0.879833
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 0.878605
CRP C-reactive protein, pentraxin-related 0.863456
MARS methionyl-tRNA synthetase 0.814693
CD59 CD59 molecule, complement regulatory protein 0.811001
MSRB2 methionine sulfoxide reductase B2 0.793771
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.783936
TDRP testis development related protein 0.781888
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.774114
IL17RC interleukin 17 receptor C 0.76431
AIF1 allograft inflammatory factor 1 0.76431
C5AR1 complement component 5a receptor 1 0.746798
DIAPH2 diaphanous-related formin 2 0.746391
KRT18 keratin 18, type I 0.746391
MMP9 matrix metallopeptidase 9 0.745172
CP ceruloplasmin (ferroxidase) 0.74436
FN1 fibronectin 1 0.734217
HMOX1 heme oxygenase 1 0.728547
COL8A1 collagen, type VIII, alpha 1 0.698715
TJP1 tight junction protein 1 0.695504
NLRP3 NLR family, pyrin domain containing 3 0.695504
NRP1 neuropilin 1 0.694301
C3AR1 complement component 3a receptor 1 0.693499
TTC33 tetratricopeptide repeat domain 33 0.682294
VLDLR very low density lipoprotein receptor 0.680297
CLDN19 claudin 19 0.673518
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.67312
CCR3 chemokine (C-C motif) receptor 3 0.665166
FTMT ferritin mitochondrial 0.663578
ERP29 endoplasmic reticulum protein 29 0.643404
PAM peptidylglycine alpha-amidating monooxygenase 0.637889
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.635921
ELANE elastase, neutrophil expressed 0.630027
OPN4 opsin 4 0.628065
ICAM1 intercellular adhesion molecule 1 0.620617
SCARB1 scavenger receptor class B, member 1 0.619051
ACER2 alkaline ceramidase 2 0.616312
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 0.616312
PLA2G12A phospholipase A2, group XIIA 0.609666
ELN elastin 0.60303
TNMD tenomodulin 0.60147
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.597961
OCLN occludin 0.597961
TSPO translocator protein (18kDa) 0.597181
STARD3 StAR-related lipid transfer (START) domain containing 3 0.595233
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.594843
CRX cone-rod homeobox 0.593674
C1QTNF5 C1q and tumor necrosis factor related protein 5 0.592116
F13B coagulation factor XIII, B polypeptide 0.591337
GSG1L GSG1-like 0.589779
BCO2 beta-carotene oxygenase 2 0.58939
FGF1 fibroblast growth factor 1 (acidic) 0.588612
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.581606
CNTF ciliary neurotrophic factor 0.578106
B3GALTL beta 1,3-galactosyltransferase-like 0.574217
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 0.569552
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.569163
CTSD cathepsin D 0.563723
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.555956
PON1 paraoxonase 1 0.553627
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.551686
DHX30 DEAH (Asp-Glu-Ala-His) box helicase 30 0.545481
CARD17 caspase recruitment domain family, member 17 0.536183
PILRA paired immunoglobin-like type 2 receptor alpha 0.535409
LOXL1 lysyl oxidase-like 1 0.530381
TXN thioredoxin 0.52536
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.522659
KEAP1 kelch-like ECH-associated protein 1 0.516494
OPTC opticin 0.512264
CD34 CD34 molecule 0.51188
CST3 cystatin C 0.507273
LPPR4 lipid phosphate phosphatase-related protein type 4 0.50689
GPX1 glutathione peroxidase 1 0.505739
FASLG Fas ligand (TNF superfamily, member 6) 0.502675
AMD1 adenosylmethionine decarboxylase 1 0.501527
PAPD4 PAP associated domain containing 4 0.497703
CETP cholesteryl ester transfer protein, plasma 0.495793
GSTP1 glutathione S-transferase pi 1 0.493885
NRL neural retina leucine zipper 0.493885
SCAPER S-phase cyclin A-associated protein in the ER 0.492359
CBX6 chromobox homolog 6 0.490454
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 0.489311
CD68 CD68 molecule 0.488549
CAT catalase 0.486266
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.479427
ANG angiogenin, ribonuclease, RNase A family, 5 0.47374
FKBPL FK506 binding protein like 0.467306
CLUL1 clusterin-like 1 (retinal) 0.46655
RHOJ ras homolog family member J 0.465038
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.462016
NFE2L2 nuclear factor, erythroid 2-like 2 0.461639
TIMP2 TIMP metallopeptidase inhibitor 2 0.458619
VWF von Willebrand factor 0.453716
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.451454
RCVRN recoverin 0.451454
APOB apolipoprotein B 0.450701
TLR4 toll-like receptor 4 0.448817
THEMIS thymocyte selection associated 0.447311
TIMP1 TIMP metallopeptidase inhibitor 1 0.443547
ARR3 arrestin 3, retinal (X-arrestin) 0.437906
HSPA4 heat shock 70kDa protein 4 0.434899
AOC3 amine oxidase, copper containing 3 0.431519
AHR aryl hydrocarbon receptor 0.431144
CTGF connective tissue growth factor 0.430017
OSBP2 oxysterol binding protein 2 0.429642
IMPG2 interphotoreceptor matrix proteoglycan 2 0.42739
BCO1 beta-carotene oxygenase 1 0.42739
GPX4 glutathione peroxidase 4 0.425514
PLG plasminogen 0.424765
PLA2G12B phospholipase A2, group XIIB 0.424014
GPR75 G protein-coupled receptor 75 0.415024
LAMB4 laminin, beta 4 0.408666
CFP complement factor properdin 0.408666
DICER1 dicer 1, ribonuclease type III 0.407172
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.406798
TP53INP1 tumor protein p53 inducible nuclear protein 1 0.404931
MME membrane metallo-endopeptidase 0.404184
TF transferrin 0.403438
CXCL12 chemokine (C-X-C motif) ligand 12 0.402318
SIRT1 sirtuin 1 0.401572
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.397098
ZCWPW1 zinc finger, CW type with PWWP domain 1 0.393746
FMOD fibromodulin 0.392629
BMP8B bone morphogenetic protein 8b 0.392629
GCLC glutamate-cysteine ligase, catalytic subunit 0.391141
GPX5 glutathione peroxidase 5 0.389653
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.388909
GLB1 galactosidase, beta 1 0.388538
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.385936
DHDH dihydrodiol dehydrogenase (dimeric) 0.383337
XPOT exportin, tRNA 0.382223
MGST1 microsomal glutathione S-transferase 1 0.381852
ANGPT1 angiopoietin 1 0.381481
VEGFC vascular endothelial growth factor C 0.379997
RBM39 RNA binding motif protein 39 0.378885
CAPZB capping protein (actin filament) muscle Z-line, beta 0.377031
DSCR8 Down syndrome critical region 8 0.37592
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.37592
BDH2 3-hydroxybutyrate dehydrogenase, type 2 0.375179
ANXA5 annexin A5 0.373328
KCTD5 potassium channel tetramerization domain containing 5 0.369997
ANGPTL7 angiopoietin-like 7 0.356341
PRPH2 peripherin 2 (retinal degeneration, slow) 0.354868
ALB albumin 0.354868
GDF6 growth differentiation factor 6 0.353763
SYN3 synapsin III 0.347511
BCL2L13 BCL2-like 13 (apoptosis facilitator) 0.344574
TNF tumor necrosis factor 0.34384
MMP3 matrix metallopeptidase 3 0.343106
PADI2 peptidyl arginine deiminase, type II 0.342739
C5 complement component 5 0.342372
C7 complement component 7 0.340173
FADS1 fatty acid desaturase 1 0.33944
THBS1 thrombospondin 1 0.338707
FILIP1L filamin A interacting protein 1-like 0.336876
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 0.33651
CLIC6 chloride intracellular channel 6 0.335046
ADIPOR1 adiponectin receptor 1 0.334315
STAT1 signal transducer and activator of transcription 1, 91kDa 0.332852
JUN jun proto-oncogene 0.329565
TMEM45A transmembrane protein 45A 0.327375
SUCNR1 succinate receptor 1 0.326646
CRYAB crystallin, alpha B 0.323002
SST somatostatin 0.318999
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.317909
RPN2 ribophorin II 0.317545
HMOX2 heme oxygenase 2 0.316092
NXNL1 nucleoredoxin-like 1 0.314278
IGF2-AS IGF2 antisense RNA 0.313189
CLIC1 chloride intracellular channel 1 0.312102
ATF4 activating transcription factor 4 0.311014
FTL ferritin, light polypeptide 0.310652
FTH1 ferritin, heavy polypeptide 1 0.310652
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 0.310652
GSTA3 glutathione S-transferase alpha 3 0.309204
ADGRG2 adhesion G protein-coupled receptor G2 0.308842
TXN2 thioredoxin 2 0.30848
GSTA2 glutathione S-transferase alpha 2 0.308118
GSTA4 glutathione S-transferase alpha 4 0.307033
IMPG1 interphotoreceptor matrix proteoglycan 1 0.303059
TYRO3 TYRO3 protein tyrosine kinase 0.302337
GSTA1 glutathione S-transferase alpha 1 0.301254
CHM choroideremia (Rab escort protein 1) 0.296931
RSAD2 radical S-adenosyl methionine domain containing 2 0.295851
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.294053
RORA RAR-related orphan receptor A 0.291898
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.289027
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.289027
SMOC2 SPARC related modular calcium binding 2 0.284013
RGR retinal G protein coupled receptor 0.283655
NRP2 neuropilin 2 0.280082
PYDC1 PYD (pyrin domain) containing 1 0.277584
COTL1 coactosin-like F-actin binding protein 1 0.277584
DDIT3 DNA-damage-inducible transcript 3 0.276158
CLU clusterin 0.275445
CLDN3 claudin 3 0.272953
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.272597
GRK1 G protein-coupled receptor kinase 1 0.27153
TMCO1 transmembrane and coiled-coil domains 1 0.269753
INVS inversin 0.268332
NDP Norrie disease (pseudoglioma) 0.268332
PRL prolactin 0.267977
CFD complement factor D (adipsin) 0.266913
VDAC3 voltage-dependent anion channel 3 0.264431
DDIT4 DNA-damage-inducible transcript 4 0.264077
MT1M metallothionein 1M 0.261599
THY1 Thy-1 cell surface antigen 0.260891
FLT4 fms-related tyrosine kinase 4 0.260184
TNXB tenascin XB 0.260184
CRYBB2 crystallin, beta B2 0.255946
MT4 metallothionein 4 0.254183
GCLM glutamate-cysteine ligase, modifier subunit 0.253479
TNXA tenascin XA (pseudogene) 0.253479
GPX3 glutathione peroxidase 3 0.252774
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.25207
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 0.25207
DNTT DNA nucleotidylexotransferase 0.250663
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.248905
IL6 interleukin 6 0.247501
RBMS2 RNA binding motif, single stranded interacting protein 2 0.242245
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 0.241895
CCL11 chemokine (C-C motif) ligand 11 0.241196
HEYL hes-related family bHLH transcription factor with YRPW motif-like 0.239799
TGFB1 transforming growth factor, beta 1 0.236312
PPARG peroxisome proliferator-activated receptor gamma 0.227297
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 0.224196
SON SON DNA binding protein 0.223509
ADIPOR2 adiponectin receptor 2 0.22145
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.218034
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.215314
TFR2 transferrin receptor 2 0.214297
GSTM5 glutathione S-transferase mu 5 0.212608
GABPB1 GA binding protein transcription factor, beta subunit 1 0.211934
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.211934
HBA1 hemoglobin, alpha 1 0.211597
FSCN2 fascin actin-bundling protein 2, retinal 0.209583
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.209248
F8 coagulation factor VIII, procoagulant component 0.205916
TLR2 toll-like receptor 2 0.205585
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.204923
SLC39A2 solute carrier family 39 (zinc transporter), member 2 0.201962
CLIC4 chloride intracellular channel 4 0.201962
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.200656
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.200006
PDGFC platelet derived growth factor C 0.19582
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.194232
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.192971
AGER advanced glycosylation end product-specific receptor 0.192657
HBA2 hemoglobin, alpha 2 0.192657
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.192344
ROM1 retinal outer segment membrane protein 1 0.192031
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.192031
MUTYH mutY homolog 0.191719
BMP4 bone morphogenetic protein 4 0.190786
CALB1 calbindin 1, 28kDa 0.190168
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.189859
SYT7 synaptotagmin VII 0.189244
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.189244
ELOVL5 ELOVL fatty acid elongase 5 0.188938
IGF1 insulin-like growth factor 1 (somatomedin C) 0.188632
IL17A interleukin 17A 0.188326
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.188022
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) 0.18651
ANGPT2 angiopoietin 2 0.18621
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 0.184128
BEND3 BEN domain containing 3 0.183541
BBC3 BCL2 binding component 3 0.183248
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.182957
VSIG4 V-set and immunoglobulin domain containing 4 0.180084
IL1B interleukin 1, beta 0.178403
CEL carboxyl ester lipase 0.176485
C1S complement component 1, s subcomponent 0.176485
BACE2 beta-site APP-cleaving enzyme 2 0.176215
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.175411
SQSTM1 sequestosome 1 0.174617
ADAM9 ADAM metallopeptidase domain 9 0.174617
TGOLN2 trans-golgi network protein 2 0.172544
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 0.171785
IGFALS insulin-like growth factor binding protein, acid labile subunit 0.171785
HMGB1 high mobility group box 1 0.171535
ELF5 E74-like factor 5 (ets domain transcription factor) 0.171286
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.170544
FRK fyn-related Src family tyrosine kinase 0.169812
SNAP91 synaptosomal-associated protein, 91kDa 0.16933
SELE selectin E 0.169091
MBD2 methyl-CpG binding domain protein 2 0.168854
F10 coagulation factor X 0.167915
SLC7A4 solute carrier family 7, member 4 0.167682
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 0.165217
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.164149
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.162908
RBP4 retinol binding protein 4, plasma 0.162908
GRIP1 glutamate receptor interacting protein 1 0.160948
UNG uracil-DNA glycosylase 0.160021
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.15948
SCARB2 scavenger receptor class B, member 2 0.15948
GUCA1A guanylate cyclase activator 1A (retina) 0.15948
ELOVL2 ELOVL fatty acid elongase 2 0.159124
TAS2R38 taste receptor, type 2, member 38 0.158951
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 0.158778
PRELP proline/arginine-rich end leucine-rich repeat protein 0.157929
AGTR1 angiotensin II receptor, type 1 0.157929