adult t-cell leukemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions. (Human Disease Ontology, DOID_0050523)
Similar Terms
Downloads & Tools

Genes

258 genes co-occuring with the disease adult t-cell leukemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
HBZ hemoglobin, zeta 2.28734
IL2RA interleukin 2 receptor, alpha 2.03065
CNTN2 contactin 2 (axonal) 1.95394
CD4 CD4 molecule 1.92904
IL2 interleukin 2 1.86186
TXN thioredoxin 1.75958
ATL2 atlastin GTPase 2 1.62381
JUND jun D proto-oncogene 1.51721
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.49877
PTHLH parathyroid hormone-like hormone 1.49043
CREB1 cAMP responsive element binding protein 1 1.45529
CENPV centromere protein V 1.37556
PLVAP plasmalemma vesicle associated protein 1.3664
CD7 CD7 molecule 1.29309
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.09167
TP53 tumor protein p53 1.0774
FOXP3 forkhead box P3 1.02229
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.01765
CD5 CD5 molecule 0.998236
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.991487
CCND2 cyclin D2 0.986849
GZMM granzyme M (lymphocyte met-ase 1) 0.978848
CREBBP CREB binding protein 0.964567
TARS threonyl-tRNA synthetase 0.949519
CD2 CD2 molecule 0.944938
TRAC T cell receptor alpha constant 0.929173
IRF4 interferon regulatory factor 4 0.920085
ZNF282 zinc finger protein 282 0.918436
LOR loricrin 0.91308
JUNB jun B proto-oncogene 0.883521
BIRC5 baculoviral IAP repeat containing 5 0.8741
OAT ornithine aminotransferase 0.873281
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.834378
BCL2L1 BCL2-like 1 0.824128
ERVW-1 endogenous retrovirus group W, member 1 0.823718
JAK3 Janus kinase 3 0.798692
JUN jun proto-oncogene 0.791311
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1 0.788852
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 0.787213
FAM192A family with sequence similarity 192, member A 0.784755
CDKN2A cyclin-dependent kinase inhibitor 2A 0.772479
BCL3 B-cell CLL/lymphoma 3 0.766351
TCL1A T-cell leukemia/lymphoma 1A 0.765127
NOG noggin 0.758601
XPO1 exportin 1 0.748017
USP10 ubiquitin specific peptidase 10 0.722077
ADAM21 ADAM metallopeptidase domain 21 0.715618
CD86 CD86 molecule 0.708364
CCL22 chemokine (C-C motif) ligand 22 0.701928
TRIO trio Rho guanine nucleotide exchange factor 0.699517
CADM1 cell adhesion molecule 1 0.689092
ICAM1 intercellular adhesion molecule 1 0.683093
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase) 0.679499
BIRC3 baculoviral IAP repeat containing 3 0.6791
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 0.66596
ATN1 atrophin 1 0.664769
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 0.662387
IL2RB interleukin 2 receptor, beta 0.659611
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.659611
IL1A interleukin 1, alpha 0.657234
FOS FBJ murine osteosarcoma viral oncogene homolog 0.654858
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 0.654067
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.643009
CD52 CD52 molecule 0.641039
FUK fucokinase 0.635921
USP20 ubiquitin specific peptidase 20 0.635921
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.622967
NABP1 nucleic acid binding protein 1 0.6214
LCK LCK proto-oncogene, Src family tyrosine kinase 0.614356
GNPDA1 glucosamine-6-phosphate deaminase 1 0.612792
CDK6 cyclin-dependent kinase 6 0.612011
HLA-A major histocompatibility complex, class I, A 0.611229
HLA-C major histocompatibility complex, class I, C 0.610057
HMP19 HMP19 protein 0.604591
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.60342
TFRC transferrin receptor 0.59874
CDK4 cyclin-dependent kinase 4 0.58939
RASA2 RAS p21 protein activator 2 0.587833
MTAP methylthioadenosine phosphorylase 0.587444
CCL3 chemokine (C-C motif) ligand 3 0.585108
ALK anaplastic lymphoma receptor tyrosine kinase 0.570329
PTH parathyroid hormone 0.5645
ADA adenosine deaminase 0.559839
FOXN2 forkhead box N2 0.551686
B2M beta-2-microglobulin 0.544705
CD3D CD3d molecule, delta (CD3-TCR complex) 0.540055
SH2D1A SH2 domain containing 1A 0.535409
CXCR3 chemokine (C-X-C motif) receptor 3 0.533861
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.533475
KAT2B K(lysine) acetyltransferase 2B 0.533475
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.532701
TSC22D1 TSC22 domain family, member 1 0.530381
NCAM1 neural cell adhesion molecule 1 0.529994
BIRC2 baculoviral IAP repeat containing 2 0.529994
IFNA1 interferon, alpha 1 0.528835
MIR130B microRNA 130b 0.527676
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.524974
BTK Bruton agammaglobulinemia tyrosine kinase 0.519961
RPS25 ribosomal protein S25 0.51842
CCL27 chemokine (C-C motif) ligand 27 0.517649
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 0.517265
CD80 CD80 molecule 0.514571
PANX3 pannexin 3 0.511496
PDCD11 programmed cell death 11 0.511496
LIMD2 LIM domain containing 2 0.511496
CCR7 chemokine (C-C motif) receptor 7 0.510344
ZNF10 zinc finger protein 10 0.496939
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.495793
MED10 mediator complex subunit 10 0.486266
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.479807
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.476772
RPL8 ribosomal protein L8 0.464283
MUM1 melanoma associated antigen (mutated) 1 0.462394
LTV1 LTV1 ribosome biogenesis factor 0.457109
IL1B interleukin 1, beta 0.448817
TGFB1 transforming growth factor, beta 1 0.445429
BAX BCL2-associated X protein 0.445052
CDC23 cell division cycle 23 0.443547
MVP major vault protein 0.441666
CCDC88C coiled-coil domain containing 88C 0.439786
TNF tumor necrosis factor 0.433772
MIR31 microRNA 31 0.433021
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.43227
CREM cAMP responsive element modulator 0.42814
IL9R interleukin 9 receptor 0.42589
CD38 CD38 molecule 0.425139
RAB5B RAB5B, member RAS oncogene family 0.416896
DNTT DNA nucleotidylexotransferase 0.414276
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.414276
GTF2B general transcription factor IIB 0.413901
CD8B CD8b molecule 0.413153
IL4 interleukin 4 0.405305
CCL17 chemokine (C-C motif) ligand 17 0.403064
IL15 interleukin 15 0.394491
CDK2 cyclin-dependent kinase 2 0.394118
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.393374
STRBP spermatid perinuclear RNA binding protein 0.387423
TADA1 transcriptional adaptor 1 0.382966
HDAC1 histone deacetylase 1 0.378885
MIR223 microRNA 223 0.378514
MSH3 mutS homolog 3 0.377402
FASLG Fas ligand (TNF superfamily, member 6) 0.376661
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.37592
LTA lymphotoxin alpha 0.37592
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.37555
TXNIP thioredoxin interacting protein 0.373698
CCR6 chemokine (C-C motif) receptor 6 0.368888
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.368149
FOSL1 FOS-like antigen 1 0.364085
CHPF chondroitin polymerizing factor 0.364085
CD34 CD34 molecule 0.35892
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.355604
CD58 CD58 molecule 0.351187
PDLIM7 PDZ and LIM domain 7 (enigma) 0.35082
RYBP RING1 and YY1 binding protein 0.349717
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.347144
CCND1 cyclin D1 0.345308
MYB v-myb avian myeloblastosis viral oncogene homolog 0.344941
B3GAT1 beta-1,3-glucuronyltransferase 1 0.339806
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.338707
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.337975
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.336876
ACP1 acid phosphatase 1, soluble 0.333949
IL6 interleukin 6 0.331025
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.329565
CD33 CD33 molecule 0.3292
BCL2 B-cell CLL/lymphoma 2 0.32774
SELE selectin E 0.326646
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 0.325916
PNP purine nucleoside phosphorylase 0.324823
CD19 CD19 molecule 0.324094
NAV3 neuron navigator 3 0.32009
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.319363
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.318999
REXO2 RNA exonuclease 2 0.314278
LYN LYN proto-oncogene, Src family tyrosine kinase 0.313189
SELL selectin L 0.312464
PRDX5 peroxiredoxin 5 0.312102
ASXL2 additional sex combs like transcriptional regulator 2 0.309928
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.307033
RANBP1 RAN binding protein 1 0.307033
SOX4 SRY (sex determining region Y)-box 4 0.302698
TERT telomerase reverse transcriptase 0.301615
INADL InaD-like (Drosophila) 0.300533
RNASET2 ribonuclease T2 0.299812
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.296211
DYNLT1 dynein, light chain, Tctex-type 1 0.295132
CD44 CD44 molecule (Indian blood group) 0.293694
ANK1 ankyrin 1, erythrocytic 0.293334
IL9 interleukin 9 0.292616
NFYB nuclear transcription factor Y, beta 0.290821
CCNB1 cyclin B1 0.289027
E2F4 E2F transcription factor 4, p107/p130-binding 0.285086
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.281868
PANX2 pannexin 2 0.281153
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.280796
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.274376
TSPAN1 tetraspanin 1 0.272597
CCR8 chemokine (C-C motif) receptor 8 0.271886
CD69 CD69 molecule 0.267622
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 0.26266
IL5 interleukin 5 0.261952
CCL21 chemokine (C-C motif) ligand 21 0.260184
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.253127
ZEB1 zinc finger E-box binding homeobox 1 0.248203
IL17RB interleukin 17 receptor B 0.246448
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 0.242245
STAC SH3 and cysteine rich domain 0.232142
RAG1 recombination activating gene 1 0.231795
HLA-B major histocompatibility complex, class I, B 0.229716
PARP1 poly (ADP-ribose) polymerase 1 0.227642
MTA1 metastasis associated 1 0.227297
STK25 serine/threonine kinase 25 0.222479
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.220081
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.21974
CNTN3 contactin 3 (plasmacytoma associated) 0.218374
CD27 CD27 molecule 0.218034
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.214636
SMAD3 SMAD family member 3 0.213283
ICOS inducible T-cell co-stimulator 0.207912
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.207245
PTH1R parathyroid hormone 1 receptor 0.205916
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.205254
PTTG1 pituitary tumor-transforming 1 0.200656
MKNK1 MAP kinase interacting serine/threonine kinase 1 0.199356
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.198386
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.198064
PTPRC protein tyrosine phosphatase, receptor type, C 0.196459
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.196139
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.194548
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.194232
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.192031
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.191719
FXYD5 FXYD domain containing ion transport regulator 5 0.189244
SOCS1 suppressor of cytokine signaling 1 0.186811
DAP death-associated protein 0.186811
NFYA nuclear transcription factor Y, alpha 0.18472
CHL1 cell adhesion molecule L1-like 0.181222
CAV1 caveolin 1, caveolae protein, 22kDa 0.180367
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.180084
TIGAR TP53 induced glycolysis regulatory phosphatase 0.17896
HDAC9 histone deacetylase 9 0.176485
CD79A CD79a molecule, immunoglobulin-associated alpha 0.175146
CCND3 cyclin D3 0.175146
RGS1 regulator of G-protein signaling 1 0.173832
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.173057
JAK1 Janus kinase 1 0.171286
PTMS parathymosin 0.170789
TAL1 T-cell acute lymphocytic leukemia 1 0.170299
TSPAN7 tetraspanin 7 0.166544
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.165874
CDC27 cell division cycle 27 0.165655
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.162306
UBE2N ubiquitin-conjugating enzyme E2N 0.160948
TPR translocated promoter region, nuclear basket protein 0.160761
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.160203
NPRL3 nitrogen permease regulator-like 3 (S. cerevisiae) 0.158778
HDAC7 histone deacetylase 7 0.157765