adult respiratory distress syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. (Human Disease Ontology, DOID_11394)
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Genes

273 genes co-occuring with the disease adult respiratory distress syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ELANE elastase, neutrophil expressed 1.87056
CXCL8 chemokine (C-X-C motif) ligand 8 1.74324
TNF tumor necrosis factor 1.7396
ALB albumin 1.68091
C5AR1 complement component 5a receptor 1 1.66149
SFTPB surfactant protein B 1.54805
IL1B interleukin 1, beta 1.52072
MPO myeloperoxidase 1.49218
IL6 interleukin 6 1.40264
SFTPD surfactant protein D 1.40001
F3 coagulation factor III (thromboplastin, tissue factor) 1.28173
PLA2G1B phospholipase A2, group IB (pancreas) 1.2656
ICAM1 intercellular adhesion molecule 1 1.24732
FGF7 fibroblast growth factor 7 1.19618
TF transferrin 1.17593
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.17121
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.15581
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.10931
MED27 mediator complex subunit 27 1.10384
THBD thrombomodulin 1.09671
PLA2G10 phospholipase A2, group X 1.08747
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.08495
SFTPC surfactant protein C 1.03409
CRP C-reactive protein, pentraxin-related 1.00794
ACE2 angiotensin I converting enzyme 2 1.0033
SOD2 superoxide dismutase 2, mitochondrial 1.00077
ACE angiotensin I converting enzyme 0.9898
SELL selectin L 0.984743
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 0.977585
PLG plasminogen 0.973801
IL10 interleukin 10 0.965825
ANK1 ankyrin 1, erythrocytic 0.939119
XKR3 XK, Kell blood group complex subunit-related family, member 3 0.930414
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.904032
AGER advanced glycosylation end product-specific receptor 0.897872
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 0.879014
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.873691
AQP1 aquaporin 1 (Colton blood group) 0.863865
HMGB1 high mobility group box 1 0.851173
CSAD cysteine sulfinic acid decarboxylase 0.828229
KIAA0101 KIAA0101 0.824538
FN1 fibronectin 1 0.817976
HABP2 hyaluronan binding protein 2 0.811411
CCL2 chemokine (C-C motif) ligand 2 0.81059
ANGPT2 angiopoietin 2 0.80977
CTSG cathepsin G 0.804846
HMOX1 heme oxygenase 1 0.798282
PLAT plasminogen activator, tissue 0.798282
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) 0.779841
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.777795
CAT catalase 0.773296
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.77207
F2 coagulation factor II (thrombin) 0.770027
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.759416
SELE selectin E 0.756564
NOS2 nitric oxide synthase 2, inducible 0.755342
OR1A1 olfactory receptor, family 1, subfamily A, member 1 0.751271
GSN gelsolin 0.739488
MUC1 mucin 1, cell surface associated 0.738676
IL36B interleukin 36, beta 0.736243
CXCR2 chemokine (C-X-C motif) receptor 2 0.735027
VWF von Willebrand factor 0.730571
TLR4 toll-like receptor 4 0.722886
POPDC3 popeye domain containing 3 0.698313
CXCL10 chemokine (C-X-C motif) ligand 10 0.697911
IL1RN interleukin 1 receptor antagonist 0.694301
KNG1 kininogen 1 0.692697
CDH5 cadherin 5, type 2 (vascular endothelium) 0.689893
MMP9 matrix metallopeptidase 9 0.685491
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.679499
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.674315
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.669538
VCAM1 vascular cell adhesion molecule 1 0.662784
IL1A interleukin 1, alpha 0.659611
MAPK14 mitogen-activated protein kinase 14 0.650903
MED26 mediator complex subunit 26 0.641827
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.63042
ANGPT1 angiopoietin 1 0.629635
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.621792
REXO2 RNA exonuclease 2 0.610057
CXCR1 chemokine (C-X-C motif) receptor 1 0.59874
KIN Kin17 DNA and RNA binding protein 0.595233
IFT81 intraflagellar transport 81 0.590948
NOS3 nitric oxide synthase 3 (endothelial cell) 0.588222
KLKB1 kallikrein B, plasma (Fletcher factor) 1 0.578494
MMP2 matrix metallopeptidase 2 0.573828
UBQLN3 ubiquilin 3 0.570329
CXCL5 chemokine (C-X-C motif) ligand 5 0.569163
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.561004
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.557509
C4A complement component 4A (Rodgers blood group) 0.55518
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.543155
ARSD arylsulfatase D 0.537344
PLA2G4D phospholipase A2, group IVD (cytosolic) 0.535409
CSF3 colony stimulating factor 3 (granulocyte) 0.530381
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.529608
NAMPT nicotinamide phosphoribosyltransferase 0.51611
CD4 CD4 molecule 0.507657
ADI1 acireductone dioxygenase 1 0.504973
FASLG Fas ligand (TNF superfamily, member 6) 0.504207
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.502675
HSPA4 heat shock 70kDa protein 4 0.499997
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 0.498467
VTA1 vesicle (multivesicular body) trafficking 1 0.497703
SFTPA1 surfactant protein A1 0.496939
PPCS phosphopantothenoylcysteine synthetase 0.495411
TFCP2 transcription factor CP2 0.493503
NOX1 NADPH oxidase 1 0.489691
USP33 ubiquitin specific peptidase 33 0.48893
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.487788
FTL ferritin, light polypeptide 0.487027
OSCAR osteoclast associated, immunoglobulin-like receptor 0.483604
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.483224
F12 coagulation factor XII (Hageman factor) 0.481325
AQP5 aquaporin 5 0.480566
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.474877
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.473361
TSPO translocator protein (18kDa) 0.471846
PI3 peptidase inhibitor 3, skin-derived 0.470332
KRT75 keratin 75, type II 0.46655
DNAH8 dynein, axonemal, heavy chain 8 0.463905
CXCL2 chemokine (C-X-C motif) ligand 2 0.461639
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.460883
HBA2 hemoglobin, alpha 2 0.460129
C1S complement component 1, s subcomponent 0.456732
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 0.456732
FTH1 ferritin, heavy polypeptide 1 0.452208
LTA lymphotoxin alpha 0.449947
EDN1 endothelin 1 0.449571
NPR1 natriuretic peptide receptor 1 0.448817
GUCY2C guanylate cyclase 2C 0.447687
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 0.446182
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.443171
TIMP1 TIMP metallopeptidase inhibitor 1 0.440914
C5 complement component 5 0.436402
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.43227
TGFB1 transforming growth factor, beta 1 0.431894
LTF lactotransferrin 0.42814
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 0.42814
AZU1 azurocidin 1 0.427015
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.42364
ESAM endothelial cell adhesion molecule 0.421765
MLX MLX, MAX dimerization protein 0.419892
VEGFA vascular endothelial growth factor A 0.419142
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 0.416521
CCL3 chemokine (C-C motif) ligand 3 0.414276
EPHX2 epoxide hydrolase 2, cytoplasmic 0.413527
PLAU plasminogen activator, urokinase 0.40904
SFTPA2 surfactant protein A2 0.407919
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.407919
LBP lipopolysaccharide binding protein 0.402692
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.402692
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.401199
GUSB glucuronidase, beta 0.399334
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 0.396353
MYLK myosin light chain kinase 0.391141
GC group-specific component (vitamin D binding protein) 0.388909
PCYT1B phosphate cytidylyltransferase 1, choline, beta 0.386679
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.382223
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.381852
F8 coagulation factor VIII, procoagulant component 0.381481
KLK15 kallikrein-related peptidase 15 0.379256
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 0.375179
TREM1 triggering receptor expressed on myeloid cells 1 0.374068
CP ceruloplasmin (ferroxidase) 0.374068
ACO2 aconitase 2, mitochondrial 0.372958
PPAN peter pan homolog (Drosophila) 0.354131
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.351187
ARHGAP24 Rho GTPase activating protein 24 0.350452
ESM1 endothelial cell-specific molecule 1 0.343473
ZC3H12D zinc finger CCCH-type containing 12D 0.340906
UST uronyl-2-sulfotransferase 0.338341
WAPAL wings apart-like homolog (Drosophila) 0.337242
BCL3 B-cell CLL/lymphoma 3 0.334315
ARHGAP21 Rho GTPase activating protein 21 0.333218
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.333218
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.332852
CYGB cytoglobin 0.328105
GPR162 G protein-coupled receptor 162 0.320454
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 0.320454
CDKN2A cyclin-dependent kinase inhibitor 2A 0.319363
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.318272
S100A12 S100 calcium binding protein A12 0.317182
NPPA natriuretic peptide A 0.315366
S1PR3 sphingosine-1-phosphate receptor 3 0.309204
RAB10 RAB10, member RAS oncogene family 0.307395
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 0.307033
UBN1 ubinuclein 1 0.307033
SOD3 superoxide dismutase 3, extracellular 0.305226
COX5A cytochrome c oxidase subunit Va 0.304503
POMC proopiomelanocortin 0.303059
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.302698
FDPS farnesyl diphosphate synthase 0.299452
STAT1 signal transducer and activator of transcription 1, 91kDa 0.298731
ARF5 ADP-ribosylation factor 5 0.295851
GPX1 glutathione peroxidase 1 0.293334
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 0.286877
NFIL3 nuclear factor, interleukin 3 regulated 0.285802
KCNRG potassium channel regulator 0.282225
PARP9 poly (ADP-ribose) polymerase family, member 9 0.280439
RBM8A RNA binding motif protein 8A 0.280082
LCMT2 leucine carboxyl methyltransferase 2 0.279367
IL2 interleukin 2 0.279011
IL22RA2 interleukin 22 receptor, alpha 2 0.278654
TPRG1L tumor protein p63 regulated 1-like 0.275445
SMAD2 SMAD family member 2 0.275089
F9 coagulation factor IX 0.274021
NOP2 NOP2 nucleolar protein 0.27153
A1BG alpha-1-B glycoprotein 0.266203
RNASE3 ribonuclease, RNase A family, 3 0.265849
SLPI secretory leukocyte peptidase inhibitor 0.26514
NOX4 NADPH oxidase 4 0.264785
GPX5 glutathione peroxidase 5 0.264077
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.263368
GPX4 glutathione peroxidase 4 0.261245
DUOX2 dual oxidase 2 0.25877
KAT5 K(lysine) acetyltransferase 5 0.255241
SSH1 slingshot protein phosphatase 1 0.253127
IGF1 insulin-like growth factor 1 (somatomedin C) 0.25207
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.251015
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.24996
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.247852
ADM adrenomedullin 0.24715
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.245747
HSPA1A heat shock 70kDa protein 1A 0.243995
MED19 mediator complex subunit 19 0.243295
INS insulin 0.240497
TOB1 transducer of ERBB2, 1 0.238054
THEM4 thioesterase superfamily member 4 0.23353
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.229024
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.228679
LVRN laeverin 0.227297
PRF1 perforin 1 (pore forming protein) 0.225229
TAC1 tachykinin, precursor 1 0.223509
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.223165
HAND2 heart and neural crest derivatives expressed 2 0.222136
TLR5 toll-like receptor 5 0.216332
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.215992
IPP intracisternal A particle-promoted polypeptide 0.213621
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.212945
FXYD1 FXYD domain containing ion transport regulator 1 0.207245
IL18 interleukin 18 0.204593
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.203275
CD209 CD209 molecule 0.20229
CCL4L2 chemokine (C-C motif) ligand 4-like 2 0.199033
MTCH2 mitochondrial carrier 2 0.198709
CASR calcium-sensing receptor 0.198386
BBS2 Bardet-Biedl syndrome 2 0.196459
TRPV6 transient receptor potential cation channel, subfamily V, member 6 0.195501
MIR146A microRNA 146a 0.195183
DSPP dentin sialophosphoprotein 0.195183
CKLF chemokine-like factor 0.192971
CCL4L1 chemokine (C-C motif) ligand 4-like 1 0.192971
CAV1 caveolin 1, caveolae protein, 22kDa 0.192971
LYZ lysozyme 0.190168
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.184424
PFDN4 prefoldin subunit 4 0.184424
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.183248
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.182086
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.180084
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.180084
CARD17 caspase recruitment domain family, member 17 0.17896
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.174881
CYBRD1 cytochrome b reductase 1 0.170789
HP haptoglobin 0.170054
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.16933
AMY2A amylase, alpha 2A (pancreatic) 0.167915
HPR haptoglobin-related protein 0.166319
TIAM1 T-cell lymphoma invasion and metastasis 1 0.165874
PARP1 poly (ADP-ribose) polymerase 1 0.165001
CD59 CD59 molecule, complement regulatory protein 0.162707
MSMB microseminoprotein, beta- 0.161716
PXN paxillin 0.15948