adrenal cortical hypofunction Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
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Genes

112 genes co-occuring with the disease adrenal cortical hypofunction in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
POMC proopiomelanocortin 2.31793
AIRE autoimmune regulator 2.10329
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.8839
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 1.84818
CRH corticotropin releasing hormone 1.36509
REN renin 1.22692
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.22475
MICA MHC class I polypeptide-related sequence A 1.20785
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 1.02945
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.0071
INS insulin 1.00035
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.986849
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.973801
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.97212
CLEC16A C-type lectin domain family 16, member A 0.947435
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.91308
TPO thyroid peroxidase 0.905675
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.880243
CIITA class II, major histocompatibility complex, transactivator 0.833558
ADAM3A ADAM metallopeptidase domain 3A (pseudogene) 0.831918
IFIH1 interferon induced with helicase C domain 1 0.822488
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.804846
TG thyroglobulin 0.764718
HLA-C major histocompatibility complex, class I, C 0.764718
CLEC2D C-type lectin domain family 2, member D 0.761862
OSBPL9 oxysterol binding protein-like 9 0.755749
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.753306
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 0.749644
NLRP1 NLR family, pyrin domain containing 1 0.743954
CRHBP corticotropin releasing hormone binding protein 0.733406
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.731786
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.727333
PTPRD protein tyrosine phosphatase, receptor type, D 0.720461
AVP arginine vasopressin 0.692296
PFKL phosphofructokinase, liver 0.669936
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.669538
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.659611
TPH1 tryptophan hydroxylase 1 0.652484
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.650508
MIER1 mesoderm induction early response 1, transcriptional regulator 0.636315
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.610057
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 0.585108
STXBP5 syntaxin binding protein 5 (tomosyn) 0.546256
TRH thyrotropin-releasing hormone 0.524588
FDX1 ferredoxin 1 0.521117
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 0.517649
TSGA10 testis specific, 10 0.514956
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.513802
NLRP5 NLR family, pyrin domain containing 5 0.513802
HLA-DQB3 major histocompatibility complex, class II, DQ beta 3 0.504973
FCRL3 Fc receptor-like 3 0.498085
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.472604
HYLS1 hydrolethalus syndrome 1 0.460129
PRL prolactin 0.458241
HLA-B major histocompatibility complex, class I, B 0.457109
WDR11 WD repeat domain 11 0.444676
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.430768
AVPR1B arginine vasopressin receptor 1B 0.42139
SIAE sialic acid acetylesterase 0.421016
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 0.415398
GIF gastric intrinsic factor (vitamin B synthesis) 0.410161
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.382966
HLA-E major histocompatibility complex, class I, E 0.37592
GAST gastrin 0.373698
C7ORF49 chromosome 7 open reading frame 49 0.371847
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.362978
PLEKHG5 pleckstrin homology domain containing, family G (with RhoGef domain) member 5 0.354131
GK glycerol kinase 0.351187
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.347511
STAR steroidogenic acute regulatory protein 0.347144
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.344574
CD79A CD79a molecule, immunoglobulin-associated alpha 0.333949
HLA-A major histocompatibility complex, class I, A 0.332852
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.32993
PDCD1 programmed cell death 1 0.325916
CXCL10 chemokine (C-X-C motif) ligand 10 0.317545
NPPA natriuretic peptide A 0.305587
LHX4 LIM homeobox 4 0.303781
CASR calcium-sensing receptor 0.291898
ORM1 orosomucoid 1 0.259124
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 0.259124
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.252774
MINK1 misshapen-like kinase 1 0.25207
SHBG sex hormone-binding globulin 0.250663
CXCL11 chemokine (C-X-C motif) ligand 11 0.248203
PGM3 phosphoglucomutase 3 0.248203
BEAN1 brain expressed, associated with NEDD4, 1 0.241196
HIF3A hypoxia inducible factor 3, alpha subunit 0.231448
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.223509
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.218034
TRIM24 tripartite motif containing 24 0.216672
ALDOB aldolase B, fructose-bisphosphate 0.216332
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.211597
SUMO4 small ubiquitin-like modifier 4 0.208579
CRHR1 corticotropin releasing hormone receptor 1 0.204593
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.201635
IFNA1 interferon, alpha 1 0.200331
PTH parathyroid hormone 0.200331
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.193285
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.192657
STAT4 signal transducer and activator of transcription 4 0.182666
SOX3 SRY (sex determining region Y)-box 3 0.177029
CD274 CD274 molecule 0.175146
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.173571
FLAD1 flavin adenine dinucleotide synthetase 1 0.172799
GHRH growth hormone releasing hormone 0.172291
ALDOA aldolase A, fructose-bisphosphate 0.169571
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.162306
HESX1 HESX homeobox 1 0.162109
C4A complement component 4A (Rodgers blood group) 0.161912
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.157765
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.157602