adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus. (Gene Ontology, GO_0002460)
External Link http://amigo.geneontology.org/amigo/term/GO:0002460
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Genes

52 genes participating in the adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
BCL10 B-cell CLL/lymphoma 10
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BTN3A2 butyrophilin, subfamily 3, member A2
BTN3A3 butyrophilin, subfamily 3, member A3
CADM1 cell adhesion molecule 1
CD27 CD27 molecule
CD46 CD46 molecule, complement regulatory protein
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CRTAM cytotoxic and regulatory T cell molecule
CTSC cathepsin C
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
DLG1 discs, large homolog 1 (Drosophila)
EBI3 Epstein-Barr virus induced 3
EMP2 epithelial membrane protein 2
EXO1 exonuclease 1
FAS Fas cell surface death receptor
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
GNL1 guanine nucleotide binding protein-like 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL12B interleukin 12B
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL4 interleukin 4
IRF7 interferon regulatory factor 7
JAG1 jagged 1
KLHL6 kelch-like family member 6
LYST lysosomal trafficking regulator
MEF2C myocyte enhancer factor 2C
MICA MHC class I polypeptide-related sequence A
MICB MHC class I polypeptide-related sequence B
MSH2 mutS homolog 2
MYO1G myosin IG
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
PRKCD protein kinase C, delta
RAET1E retinoic acid early transcript 1E
SLA2 Src-like-adaptor 2
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
TGFB1 transforming growth factor, beta 1
TLR4 toll-like receptor 4
TLR6 toll-like receptor 6
TLR8 toll-like receptor 8
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UNC13D unc-13 homolog D (C. elegans)
ZP3 zona pellucida glycoprotein 3 (sperm receptor)