acute promyelocytic leukemia cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description A subtype of acute myelogenous leukemia (AML), a cancer of the blood and bone marrow. In APL, there is an abnormal accumulation of immature granulocytes called promyelocytes. (BRENDA Tissue and Enzyme Source Ontology, BTO_0004585)
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Genes

189 proteins co-occuring with the tissue acute promyelocytic leukemia cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
RARA retinoic acid receptor, alpha 2.93589
PML promyelocytic leukemia 2.22038
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.62058
ZBTB16 zinc finger and BTB domain containing 16 1.58584
CD33 CD33 molecule 1.51759
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 1.51664
PRAM1 PML-RARA regulated adaptor molecule 1 1.46216
ASB2 ankyrin repeat and SOCS box containing 2 1.41399
RARS arginyl-tRNA synthetase 1.37682
UBA7 ubiquitin-like modifier activating enzyme 7 1.35177
ANXA8 annexin A8 1.32506
BLZF1 basic leucine zipper nuclear factor 1 1.2452
CHMP5 charged multivesicular body protein 5 1.18201
NCOR1 nuclear receptor corepressor 1 1.15628
USP37 ubiquitin specific peptidase 37 1.14786
F3 coagulation factor III (thromboplastin, tissue factor) 1.11509
ANXA5 annexin A5 1.04885
THBD thrombomodulin 1.01156
ZSWIM2 zinc finger, SWIM-type containing 2 1.00763
ANXA2 annexin A2 0.986728
IRF1 interferon regulatory factor 1 0.983254
WIPI2 WD repeat domain, phosphoinositide interacting 2 0.976749
PGM3 phosphoglucomutase 3 0.966793
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.958154
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.918206
BAX BCL2-associated X protein 0.912653
DAXX death-domain associated protein 0.903275
CTSG cathepsin G 0.875706
IRF9 interferon regulatory factor 9 0.854209
CD34 CD34 molecule 0.840769
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.836156
G0S2 G0/G1 switch 2 0.826523
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.825686
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.821921
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 0.803544
HSH2D hematopoietic SH2 domain containing 0.803544
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 0.793126
USP18 ubiquitin specific peptidase 18 0.762397
HDAC9 histone deacetylase 9 0.750405
PHB prohibitin 0.731442
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.730208
SPI1 Spi-1 proto-oncogene 0.698216
ISG20 interferon stimulated exonuclease gene 20kDa 0.686368
TOP2B topoisomerase (DNA) II beta 180kDa 0.683919
HK3 hexokinase 3 (white cell) 0.683103
GABARAPL2 GABA(A) receptor-associated protein-like 2 0.674135
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.672506
PHF8 PHD finger protein 8 0.66925
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.661523
JUN jun proto-oncogene 0.661523
ISG15 ISG15 ubiquitin-like modifier 0.658678
STAT2 signal transducer and activator of transcription 2, 113kDa 0.656242
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.652994
STAT1 signal transducer and activator of transcription 1, 91kDa 0.625465
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.621428
DBNL drebrin-like 0.600881
IFNA1 interferon, alpha 1 0.59646
CD38 CD38 molecule 0.588031
BCL2L1 BCL2-like 1 0.586828
AQP9 aquaporin 9 0.584022
GALM galactose mutarotase (aldose 1-epimerase) 0.578416
RNF4 ring finger protein 4 0.574017
BCL2 B-cell CLL/lymphoma 2 0.573217
DAPK2 death-associated protein kinase 2 0.572418
MAP1S microtubule-associated protein 1S 0.572418
PDS5B PDS5 cohesin associated factor B 0.562441
SP100 SP100 nuclear antigen 0.555274
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 0.551298
FPR2 formyl peptide receptor 2 0.54812
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 0.544152
S100A10 S100 calcium binding protein A10 0.542963
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.540981
CISH cytokine inducible SH2-containing protein 0.540585
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.53267
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.529508
FLNB filamin B, beta 0.527534
BIRC5 baculoviral IAP repeat containing 5 0.520829
CCL24 chemokine (C-C motif) ligand 24 0.514924
DRAM1 DNA-damage regulated autophagy modulator 1 0.509813
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.509027
CELA2A chymotrypsin-like elastase family, member 2A 0.504318
BIRC6 baculoviral IAP repeat containing 6 0.499223
AMICA1 adhesion molecule, interacts with CXADR antigen 1 0.494528
KLF3 Kruppel-like factor 3 (basic) 0.493354
MIRLET7D microRNA let-7d 0.492182
RPA2 replication protein A2, 32kDa 0.490619
MFGE8 milk fat globule-EGF factor 8 protein 0.485156
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.483986
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.481259
HOXA1 homeobox A1 0.476201
KLF5 Kruppel-like factor 5 (intestinal) 0.474646
BCOR BCL6 corepressor 0.46766
ANK1 ankyrin 1, erythrocytic 0.466111
PARP1 poly (ADP-ribose) polymerase 1 0.463787
HOXC4 homeobox C4 0.4576
ORM2 orosomucoid 2 0.455284
ELF4 E74-like factor 4 (ets domain transcription factor) 0.442194
GABARAPL1 GABA(A) receptor-associated protein like 1 0.441426
TRIM27 tripartite motif containing 27 0.437589
MAPK8 mitogen-activated protein kinase 8 0.437589
PARK2 parkin RBR E3 ubiquitin protein ligase 0.42993
MIR146A microRNA 146a 0.422292
PLG plasminogen 0.421529
PLSCR1 phospholipid scramblase 1 0.420766
AS3MT arsenite methyltransferase 0.406694
LY6E lymphocyte antigen 6 complex, locus E 0.406315
FLNA filamin A, alpha 0.405935
MIR107 microRNA 107 0.398357
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.396087
PCGF2 polycomb group ring finger 2 0.396087
BRWD1 bromodomain and WD repeat domain containing 1 0.394197
PRKCD protein kinase C, delta 0.388912
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.387781
MAP2K4 mitogen-activated protein kinase kinase 4 0.387027
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.381003
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.377621
SIAH2 siah E3 ubiquitin protein ligase 2 0.374993
PLAT plasminogen activator, tissue 0.373493
MIR15B microRNA 15b 0.372743
CXCL8 chemokine (C-X-C motif) ligand 8 0.367876
LMO1 LIM domain only 1 (rhombotin 1) 0.366754
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.361527
MPO myeloperoxidase 0.358174
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.353712
SEC23B Sec23 homolog B (S. cerevisiae) 0.35334
ICAM1 intercellular adhesion molecule 1 0.352227
KRT10 keratin 10, type I 0.350372
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 0.348889
TNF tumor necrosis factor 0.344449
MIRLET7C microRNA let-7c 0.344079
WDR11 WD repeat domain 11 0.334865
UBE2H ubiquitin-conjugating enzyme E2H 0.333763
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.32497
CSHL1 chorionic somatomammotropin hormone-like 1 0.320227
CD9 CD9 molecule 0.316951
MBD1 methyl-CpG binding domain protein 1 0.315498
BHLHE40 basic helix-loop-helix family, member e40 0.311145
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.305722
TP53 tumor protein p53 0.304279
CD52 CD52 molecule 0.302478
NUP214 nucleoporin 214kDa 0.300679
RXRA retinoid X receptor, alpha 0.296372
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.292079
OSGEP O-sialoglycoprotein endopeptidase 0.289582
TUBB tubulin, beta class I 0.278955
CDK4 cyclin-dependent kinase 4 0.276846
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.275094
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.274744
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.272997
IRF8 interferon regulatory factor 8 0.271952
PIAS1 protein inhibitor of activated STAT, 1 0.270909
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.266069
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.264353
NCAM1 neural cell adhesion molecule 1 0.264011
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.263327
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.263327
CD44 CD44 molecule (Indian blood group) 0.262986
TCF3 transcription factor 3 0.260606
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 0.259591
ESM1 endothelial cell-specific molecule 1 0.259591
SET SET nuclear proto-oncogene 0.257907
IL3 interleukin 3 0.257572
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.25457
CDK2 cyclin-dependent kinase 2 0.253908
PRC1 protein regulator of cytokinesis 1 0.247719
CD7 CD7 molecule 0.24676
SIAH1 siah E3 ubiquitin protein ligase 1 0.24486
IL1B interleukin 1, beta 0.24486
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.243918
LTF lactotransferrin 0.23781
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 0.23604
PRDX3 peroxiredoxin 3 0.234878
NUP98 nucleoporin 98kDa 0.232039
SUMO3 small ubiquitin-like modifier 3 0.231482
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.226667
CD53 CD53 molecule 0.226155
ALPPL2 alkaline phosphatase, placental-like 2 0.224645
ALPL alkaline phosphatase, liver/bone/kidney 0.22415
ALPP alkaline phosphatase, placental 0.223662
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.222224
LEPR leptin receptor 0.221521
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.221291
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.217554
FYB FYN binding protein 0.216528
ANXA1 annexin A1 0.216126
CXCR1 chemokine (C-X-C motif) receptor 1 0.216126
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.215928
NDRG2 NDRG family member 2 0.215534
SUMO2 small ubiquitin-like modifier 2 0.214388