acute lymphocytic leukemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lymphoblastic leukemia that is characterized by over production of lymphoblasts. (Human Disease Ontology, DOID_9952)
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Genes

219 genes co-occuring with the disease acute lymphocytic leukemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ASRGL1 asparaginase like 1 2.06307
BCR breakpoint cluster region 1.59742
CD19 CD19 molecule 1.18023
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.17206
CD7 CD7 molecule 1.16863
CD34 CD34 molecule 1.07068
DNTT DNA nucleotidylexotransferase 1.06438
TOM1 target of myb1 (chicken) 0.927932
KMT2A lysine (K)-specific methyltransferase 2A 0.925452
CD33 CD33 molecule 0.924213
CD22 CD22 molecule 0.897051
TAL1 T-cell acute lymphocytic leukemia 1 0.893769
FLT3 fms-related tyrosine kinase 3 0.879833
CHL1 cell adhesion molecule L1-like 0.833968
WWC2 WW and C2 domain containing 2 0.831099
GIPC2 GIPC PDZ domain containing family, member 2 0.823308
FPGS folylpolyglutamate synthase 0.814283
AKAP17A A kinase (PRKA) anchor protein 17A 0.804436
NAT8L N-acetyltransferase 8-like (GCN5-related, putative) 0.797462
PBX1 pre-B-cell leukemia homeobox 1 0.787623
HPRT1 hypoxanthine phosphoribosyltransferase 1 0.773705
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.768393
EVPL envoplakin 0.762678
GNG12 guanine nucleotide binding protein (G protein), gamma 12 0.741517
ETV6 ets variant 6 0.733406
DHFR dihydrofolate reductase 0.727333
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 0.720865
TCF3 transcription factor 3 0.720058
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase 0.706351
FOLR3 folate receptor 3 (gamma) 0.70233
HRAS Harvey rat sarcoma viral oncogene homolog 0.694702
CCNC cyclin C 0.664372
ADA adenosine deaminase 0.6608
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 0.658818
ETV7 ets variant 7 0.653276
GLOD4 glyoxalase domain containing 4 0.651694
MED10 mediator complex subunit 10 0.650903
CXCR5 chemokine (C-X-C motif) receptor 5 0.636315
CDKN2A cyclin-dependent kinase inhibitor 2A 0.633563
CD5 CD5 molecule 0.628457
MPO myeloperoxidase 0.626103
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.622575
GIPC3 GIPC PDZ domain containing family, member 3 0.618268
HLA-A major histocompatibility complex, class I, A 0.611229
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.60303
CCR9 chemokine (C-C motif) receptor 9 0.598351
CDX4 caudal type homeobox 4 0.594843
NOMO1 NODAL modulator 1 0.585497
TLX3 T-cell leukemia homeobox 3 0.585497
CD2 CD2 molecule 0.583941
PARP9 poly (ADP-ribose) polymerase family, member 9 0.554403
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 0.554403
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.550911
CCL25 chemokine (C-C motif) ligand 25 0.550134
PEBP4 phosphatidylethanolamine-binding protein 4 0.549747
IL2 interleukin 2 0.549359
STRBP spermatid perinuclear RNA binding protein 0.547807
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.533475
HLA-C major histocompatibility complex, class I, C 0.533475
SSBP2 single-stranded DNA binding protein 2 0.522273
RGS19 regulator of G-protein signaling 19 0.521117
TPRG1L tumor protein p63 regulated 1-like 0.514571
FOLR2 folate receptor 2 (fetal) 0.485505
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.483224
IL3 interleukin 3 0.480566
RUNX1 runt-related transcription factor 1 0.477151
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.476014
OAT ornithine aminotransferase 0.476014
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.462772
RIN1 Ras and Rab interactor 1 0.460129
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.457109
C1QBP complement component 1, q subcomponent binding protein 0.452585
WWC1 WW and C2 domain containing 1 0.451078
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.449947
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.438282
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.437906
CD4 CD4 molecule 0.436778
PRAME preferentially expressed antigen in melanoma 0.428516
NUMB numb homolog (Drosophila) 0.425514
TYMS thymidylate synthetase 0.418394
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.416147
BIRC7 baculoviral IAP repeat containing 7 0.407172
CXCL13 chemokine (C-X-C motif) ligand 13 0.404557
SHMT1 serine hydroxymethyltransferase 1 (soluble) 0.403438
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.401945
MIXL1 Mix paired-like homeobox 0.391141
DCC DCC netrin 1 receptor 0.385936
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.378143
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.376661
TK1 thymidine kinase 1, soluble 0.371847
DLX4 distal-less homeobox 4 0.368888
IL2RA interleukin 2 receptor, alpha 0.366301
MX2 MX dynamin-like GTPase 2 0.362978
SARS seryl-tRNA synthetase 0.36187
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.352659
NCAM1 neural cell adhesion molecule 1 0.35082
TP53 tumor protein p53 0.35082
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1 0.350452
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.350084
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.347144
GEMIN4 gem (nuclear organelle) associated protein 4 0.344574
B2M beta-2-microglobulin 0.343473
DDN dendrin 0.341272
ALB albumin 0.340539
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.340173
LDHC lactate dehydrogenase C 0.337975
ACPP acid phosphatase, prostate 0.337608
LMO2 LIM domain only 2 (rhombotin-like 1) 0.336876
CTPS1 CTP synthase 1 0.335412
LDB1 LIM domain binding 1 0.335046
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.333949
BIRC5 baculoviral IAP repeat containing 5 0.32993
MME membrane metallo-endopeptidase 0.3292
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.32774
EIF3A eukaryotic translation initiation factor 3, subunit A 0.319726
FBXO17 F-box protein 17 0.317545
HPGDS hematopoietic prostaglandin D synthase 0.316819
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.315729
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.315729
GGT2 gamma-glutamyltransferase 2 0.313552
GSTA3 glutathione S-transferase alpha 3 0.313552
GSTA2 glutathione S-transferase alpha 2 0.312464
GSTA4 glutathione S-transferase alpha 4 0.311377
CNTFR ciliary neurotrophic factor receptor 0.31029
MNDA myeloid cell nuclear differentiation antigen 0.31029
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 0.309204
SIGLEC10 sialic acid binding Ig-like lectin 10 0.307395
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.307395
VANGL2 VANGL planar cell polarity protein 2 0.305948
GSTA1 glutathione S-transferase alpha 1 0.305587
IFNA1 interferon, alpha 1 0.305226
DVL3 dishevelled segment polarity protein 3 0.301615
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.301615
LEF1 lymphoid enhancer-binding factor 1 0.301615
ZNF382 zinc finger protein 382 0.299092
GIPC1 GIPC PDZ domain containing family, member 1 0.289027
LMO1 LIM domain only 1 (rhombotin 1) 0.287593
TOP1 topoisomerase (DNA) I 0.285802
MIR221 microRNA 221 0.283655
CTSA cathepsin A 0.280796
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.280082
NNAT neuronatin 0.274376
CD1A CD1a molecule 0.272241
KRAS Kirsten rat sarcoma viral oncogene homolog 0.27153
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.267977
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 0.265494
NT5C2 5'-nucleotidase, cytosolic II 0.261245
TMEM132D transmembrane protein 132D 0.255594
FER fer (fps/fes related) tyrosine kinase 0.252774
LPO lactoperoxidase 0.248203
LTA lymphotoxin alpha 0.247852
HRC histidine rich calcium binding protein 0.246098
STIL SCL/TAL1 interrupting locus 0.241546
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.238403
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 0.237706
POMP proteasome maturation protein 0.235616
CCL3L1 chemokine (C-C motif) ligand 3-like 1 0.23353
MYO6 myosin VI 0.230755
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.230755
FAM155B family with sequence similarity 155, member B 0.226607
DCK deoxycytidine kinase 0.22145
GGT1 gamma-glutamyltransferase 1 0.219398
CSF3 colony stimulating factor 3 (granulocyte) 0.214975
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.214636
ADD2 adducin 2 (beta) 0.213283
BCL2 B-cell CLL/lymphoma 2 0.212945
GH2 growth hormone 2 0.212945
CD9 CD9 molecule 0.212271
IL4 interleukin 4 0.210253
ZNF436 zinc finger protein 436 0.209248
TPMT thiopurine S-methyltransferase 0.205916
IGH immunoglobulin heavy locus 0.202946
IL7 interleukin 7 0.196779
NOTCH1 notch 1 0.195183
CD58 CD58 molecule 0.194548
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.1936
NUP214 nucleoporin 214kDa 0.191408
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.190786
TXN thioredoxin 0.18651
PEG10 paternally expressed 10 0.184128
CCNE2 cyclin E2 0.184128
POLL polymerase (DNA directed), lambda 0.183541
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.181798
RUNX3 runt-related transcription factor 3 0.18151
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.180084
CD38 CD38 molecule 0.178682
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.177029
LCK LCK proto-oncogene, Src family tyrosine kinase 0.176485
NADK NAD kinase 0.176215
CDX1 caudal type homeobox 1 0.175947
LDHAL6B lactate dehydrogenase A-like 6B 0.174881
WT1 Wilms tumor 1 0.174093
PREB prolactin regulatory element binding 0.173057
HVCN1 hydrogen voltage gated channel 1 0.172291
RAG2 recombination activating gene 2 0.172291
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.170054
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.16933
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.167915
SPI1 Spi-1 proto-oncogene 0.167224
PANX1 pannexin 1 0.165217
KLK10 kallikrein-related peptidase 10 0.164359
CDAN1 codanin 1 0.163938
PDLIM7 PDZ and LIM domain 7 (enigma) 0.163938
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.163523
PTK7 protein tyrosine kinase 7 (inactive) 0.162306
MNX1 motor neuron and pancreas homeobox 1 0.161716
TYRO3 TYRO3 protein tyrosine kinase 0.161523
HSPA4L heat shock 70kDa protein 4-like 0.161139
CDK4 cyclin-dependent kinase 4 0.159302
LDHA lactate dehydrogenase A 0.157929
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.141896
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.140126
CDX2 caudal type homeobox 2 0.139748
DDR1 discoidin domain receptor tyrosine kinase 1 0.134538
THBS2 thrombospondin 2 0.134392
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.132978
FGA fibrinogen alpha chain 0.132588
TNF tumor necrosis factor 0.130279
CDK2 cyclin-dependent kinase 2 0.128342