acute chest syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph. (Human Disease Ontology, DOID_1584)
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Genes

41 genes co-occuring with the disease acute chest syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
PLA2G10 phospholipase A2, group X 1.50623
PHC3 polyhomeotic homolog 3 (Drosophila) 1.44738
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.37861
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 1.36509
HBB hemoglobin, beta 1.29527
COMMD7 COMM domain containing 7 1.19014
PLA2G1B phospholipase A2, group IB (pancreas) 1.17894
KEL Kell blood group, metallo-endopeptidase 1.0071
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.95996
CYGB cytoglobin 0.929173
HBD hemoglobin, delta 0.921736
HBA1 hemoglobin, alpha 1 0.906086
GBA2 glucosidase, beta (bile acid) 2 0.887208
HBA2 hemoglobin, alpha 2 0.882292
ST5 suppression of tumorigenicity 5 0.836427
FZD5 frizzled class receptor 5 0.827409
VCAM1 vascular cell adhesion molecule 1 0.818796
SCN2A sodium channel, voltage gated, type II alpha subunit 0.787213
PTBP2 polypyrimidine tract binding protein 2 0.771252
PTBP1 polypyrimidine tract binding protein 1 0.587444
FYB FYN binding protein 0.586665
HBG2 hemoglobin, gamma G 0.558674
NOS3 nitric oxide synthase 3 (endothelial cell) 0.468819
PGF placental growth factor 0.373698
WAPAL wings apart-like homolog (Drosophila) 0.373328
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 0.372587
HPX hemopexin 0.344207
G6PD glucose-6-phosphate dehydrogenase 0.32009
TNNI3 troponin I type 3 (cardiac) 0.318999
HLA-C major histocompatibility complex, class I, C 0.304864
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.297291
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.269753
EDN1 endothelin 1 0.243995
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 0.241546
ERAS ES cell expressed Ras 0.200331
CD163 CD163 molecule 0.189551
CXCL8 chemokine (C-X-C motif) ligand 8 0.182086
ACE angiotensin I converting enzyme 0.175947
THBS1 thrombospondin 1 0.171785
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.171535
MNX1 motor neuron and pancreas homeobox 1 0.166544