acrosomal vesicle Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. (Gene Ontology, GO_0001669)
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Genes

348 proteins co-occuring with the acrosomal vesicle cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
ACR acrosin 3.28539
ZP3 zona pellucida glycoprotein 3 (sperm receptor) 2.3344
MSH6 mutS homolog 6 2.13841
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 1.85113
ACRV1 acrosomal vesicle protein 1 1.78715
TES testin LIM domain protein 1.61823
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 1.58449
CD46 CD46 molecule, complement regulatory protein 1.56959
ZP4 zona pellucida glycoprotein 4 1.52597
DPY19L2 dpy-19-like 2 (C. elegans) 1.37962
CRISP2 cysteine-rich secretory protein 2 1.35758
CSN1S1 casein alpha s1 1.30819
ALB albumin 1.29799
IZUMO1 izumo sperm-egg fusion 1 1.28623
ZPBP zona pellucida binding protein 1.28356
TCP11 t-complex 11, testis-specific 1.22101
SPAG9 sperm associated antigen 9 1.2179
SPATA16 spermatogenesis associated 16 1.21221
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 1.15109
ADAM2 ADAM metallopeptidase domain 2 1.10919
ACRBP acrosin binding protein 1.09951
ZAN zonadhesin (gene/pseudogene) 1.0934
SYT6 synaptotagmin VI 1.08577
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.08222
SPACA3 sperm acrosome associated 3 1.07714
GOPC golgi-associated PDZ and coiled-coil motif containing 1.06195
SPACA1 sperm acrosome associated 1 1.04683
PCSK4 proprotein convertase subtilisin/kexin type 4 1.02281
LYZL4 lysozyme-like 4 1.00794
PLCZ1 phospholipase C, zeta 1 0.994162
KIFC1 kinesin family member C1 0.967437
RAB3A RAB3A, member RAS oncogene family 0.962146
DKKL1 dickkopf-like 1 0.959748
CSNK2A2 casein kinase 2, alpha prime polypeptide 0.932187
VCL vinculin 0.922791
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.900426
CCIN calicin 0.895331
PATE4 prostate and testis expressed 4 0.88286
CLGN calmegin 0.875028
PATE2 prostate and testis expressed 2 0.872266
DCXR dicarbonyl/L-xylulose reductase 0.871346
LYZL6 lysozyme-like 6 0.859852
ADCY2 adenylate cyclase 2 (brain) 0.85388
SPA17 sperm autoantigenic protein 17 0.838269
PLA2G1B phospholipase A2, group IB (pancreas) 0.834597
CAT catalase 0.832761
TEX101 testis expressed 101 0.82863
OR1J2 olfactory receptor, family 1, subfamily J, member 2 0.8245
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.814864
CATSPER1 cation channel, sperm associated 1 0.811652
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.809817
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.809817
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.809359
KLK11 kallikrein-related peptidase 11 0.809359
SPESP1 sperm equatorial segment protein 1 0.806606
SPACA4 sperm acrosome associated 4 0.784156
GPX5 glutathione peroxidase 5 0.761797
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.757707
SOD2 superoxide dismutase 2, mitochondrial 0.75181
GPX4 glutathione peroxidase 4 0.738713
MIF4GD MIF4G domain containing 0.72258
GSTM5 glutathione S-transferase mu 5 0.71946
WBP2NL WBP2 N-terminal like 0.706598
GPX1 glutathione peroxidase 1 0.704831
ACPP acid phosphatase, prostate 0.698223
TNP2 transition protein 2 (during histone to protamine replacement) 0.692078
PRM1 protamine 1 0.689451
PICK1 protein interacting with PRKCA 1 0.685954
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.68508
EQTN equatorin, sperm acrosome associated 0.682463
ANXA5 annexin A5 0.680284
FABP9 fatty acid binding protein 9, testis 0.678978
MTL5 metallothionein-like 5, testis-specific (tesmin) 0.674196
H1FNT H1 histone family, member N, testis-specific 0.672026
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 0.668126
ADM adrenomedullin 0.667693
TSSK2 testis-specific serine kinase 2 0.657326
PGAM4 phosphoglycerate mutase family member 4 0.656033
TCTEX1D2 Tctex1 domain containing 2 0.656033
PAEP progestagen-associated endometrial protein 0.65345
PKDREJ polycystin (PKD) family receptor for egg jelly 0.638434
MFGE8 milk fat globule-EGF factor 8 protein 0.638005
PATE3 prostate and testis expressed 3 0.636295
CAPN11 calpain 11 0.636295
LYZL2 lysozyme-like 2 0.636295
LYZL1 lysozyme-like 1 0.636295
VSTM2A V-set and transmembrane domain containing 2A 0.636295
DYDC1 DPY30 domain containing 1 0.624355
TSKS testis-specific serine kinase substrate 0.624355
PCDHA3 protocadherin alpha 3 0.622654
CD9 CD9 molecule 0.607818
PRSS45 protease, serine, 45 0.602752
DNAH8 dynein, axonemal, heavy chain 8 0.602331
MTBP MDM2 binding protein 0.601487
SAA2 serum amyloid A2 0.59896
SMCP sperm mitochondria-associated cysteine-rich protein 0.595593
ARSA arylsulfatase A 0.584268
TSPO translocator protein (18kDa) 0.575495
CTRL chymotrypsin-like 0.573828
PGR progesterone receptor 0.569248
GGN gametogenetin 0.566338
TCTEX1D4 Tctex1 domain containing 4 0.564677
EXT2 exostosin glycosyltransferase 2 0.563847
TEKT1 tektin 1 0.555559
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 0.552664
ADCY10 adenylate cyclase 10 (soluble) 0.549773
EXT1 exostosin glycosyltransferase 1 0.541117
NASP nuclear autoantigenic sperm protein (histone-binding) 0.539472
GLIPR1L1 GLI pathogenesis-related 1 like 1 0.531258
LCN6 lipocalin 6 0.518573
CAGE1 cancer antigen 1 0.518165
NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 0.516532
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.516532
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 0.513677
MGAT4C MGAT4 family, member C 0.512455
STX2 syntaxin 2 0.510418
BSPH1 binder of sperm protein homolog 1 0.509197
LYPD4 LY6/PLAUR domain containing 4 0.50879
RIMBP3 RIMS binding protein 3 0.497015
VDAC2 voltage-dependent anion channel 2 0.49661
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.491348
HIST1H1T histone cluster 1, H1t 0.488115
GLB1 galactosidase, beta 1 0.4865
PRDX6 peroxiredoxin 6 0.483676
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 0.479245
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.476831
OVGP1 oviductal glycoprotein 1, 120kDa 0.475223
NOX5 NADPH oxidase, EF-hand calcium binding domain 5 0.470005
NT5E 5'-nucleotidase, ecto (CD73) 0.464397
DPY19L3 dpy-19-like 3 (C. elegans) 0.463198
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.461998
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 0.4608
PNMA6A paraneoplastic Ma antigen family member 6A 0.460001
DCHS2 dachsous cadherin-related 2 0.458803
POMT2 protein-O-mannosyltransferase 2 0.457208
TMEM190 transmembrane protein 190 0.456012
CALCRL calcitonin receptor-like 0.449643
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.449643
HSPA2 heat shock 70kDa protein 2 0.449245
ELSPBP1 epididymal sperm binding protein 1 0.444085
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.438146
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.435775
AZU1 azurocidin 1 0.434196
HYAL3 hyaluronoglucosaminidase 3 0.433801
AKAP4 A kinase (PRKA) anchor protein 4 0.428678
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 0.427891
CPLX2 complexin 2 0.426711
WBP2 WW domain binding protein 2 0.42396
TRIP12 thyroid hormone receptor interactor 12 0.420036
LDHC lactate dehydrogenase C 0.416511
STK31 serine/threonine kinase 31 0.41612
CNGA1 cyclic nucleotide gated channel alpha 1 0.41612
CYLC2 cylicin, basic protein of sperm head cytoskeleton 2 0.415337
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.415337
IQCG IQ motif containing G 0.414946
MARCH11 membrane-associated ring finger (C3HC4) 11 0.41182
PHF7 PHD finger protein 7 0.41182
MCM8 minichromosome maintenance complex component 8 0.410649
SYT8 synaptotagmin VIII 0.409089
CPLX1 complexin 1 0.40675
CD59 CD59 molecule, complement regulatory protein 0.403248
SPAG8 sperm associated antigen 8 0.401693
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.400139
DEGS2 delta(4)-desaturase, sphingolipid 2 0.398199
RAB2B RAB2B, member RAS oncogene family 0.394323
PHTF1 putative homeodomain transcription factor 1 0.394323
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.393936
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.388909
TNP1 transition protein 1 (during histone to protamine replacement) 0.387751
GBA2 glucosidase, beta (bile acid) 2 0.386208
GNPDA1 glucosamine-6-phosphate deaminase 1 0.385822
GPR83 G protein-coupled receptor 83 0.385051
PLA2G3 phospholipase A2, group III 0.383895
TMOD4 tropomodulin 4 (muscle) 0.382354
GLRA3 glycine receptor, alpha 3 0.37966
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 0.379276
SPANXA2 SPANX family, member A2 0.379276
PRSS58 protease, serine, 58 0.378891
MRC1 mannose receptor, C type 1 0.377738
PER1 period circadian clock 1 0.37697
CALCA calcitonin-related polypeptide alpha 0.373516
SAA1 serum amyloid A1 0.373132
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 0.37045
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.367771
SP3 Sp3 transcription factor 0.364331
FNDC3A fibronectin type III domain containing 3A 0.363949
GLRB glycine receptor, beta 0.362804
SNAP29 synaptosomal-associated protein, 29kDa 0.358609
HYAL4 hyaluronoglucosaminidase 4 0.357086
TEKT3 tektin 3 0.354042
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.349105
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.344178
SEC23IP SEC23 interacting protein 0.343042
PRM2 protamine 2 0.341907
TYSND1 trypsin domain containing 1 0.341907
SUN5 Sad1 and UNC84 domain containing 5 0.340017
PLA2G5 phospholipase A2, group V 0.336996
CD79A CD79a molecule, immunoglobulin-associated alpha 0.336241
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 0.33511
CLK3 CDC-like kinase 3 0.333225
DEFB126 defensin, beta 126 0.331342
LALBA lactalbumin, alpha- 0.330966
TPST2 tyrosylprotein sulfotransferase 2 0.328332
FTL ferritin, light polypeptide 0.327956
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.327581
ZPBP2 zona pellucida binding protein 2 0.327205
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.326829
FTH1 ferritin, heavy polypeptide 1 0.326078
EPPIN epididymal peptidase inhibitor 0.314839
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 0.314839
RUNDC3A RUN domain containing 3A 0.314839
KLK1 kallikrein 1 0.313718
GGNBP1 gametogenetin binding protein 1 (pseudogene) 0.312224
HIST1H1A histone cluster 1, H1a 0.311851
MAN2A2 mannosidase, alpha, class 2A, member 2 0.30626
PRSS1 protease, serine, 1 (trypsin 1) 0.305888
CAPZA3 capping protein (actin filament) muscle Z-line, alpha 3 0.303283
TGM6 transglutaminase 6 0.301054
WRNIP1 Werner helicase interacting protein 1 0.29994
SHBG sex hormone-binding globulin 0.299569
CATSPER4 cation channel, sperm associated 4 0.298455
LCN8 lipocalin 8 0.296601
NSF N-ethylmaleimide-sensitive factor 0.291047
PER2 period circadian clock 2 0.290678
FLOT2 flotillin 2 0.289569
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.285876
PTPN7 protein tyrosine phosphatase, non-receptor type 7 0.281821
SELENBP1 selenium binding protein 1 0.281453
CREM cAMP responsive element modulator 0.279612
PLA2G2D phospholipase A2, group IID 0.279612
LGALS7 lectin, galactoside-binding, soluble, 7 0.279245
C4BPA complement component 4 binding protein, alpha 0.278877
ZNF77 zinc finger protein 77 0.278509
RAB2A RAB2A, member RAS oncogene family 0.274468
CATSPER3 cation channel, sperm associated 3 0.274101
CKB creatine kinase, brain 0.273367
HSPA4 heat shock 70kDa protein 4 0.2719
ADAM15 ADAM metallopeptidase domain 15 0.271533
ACE angiotensin I converting enzyme 0.2708
CFC1 cripto, FRL-1, cryptic family 1 0.269701
PRDX5 peroxiredoxin 5 0.269335
STX1B syntaxin 1B 0.267871
ASTL astacin-like metallo-endopeptidase (M12 family) 0.266042
PFN3 profilin 3 0.264946
CALR3 calreticulin 3 0.263485
USP8 ubiquitin specific peptidase 8 0.260931
DUSP9 dual specificity phosphatase 9 0.259473
TPST1 tyrosylprotein sulfotransferase 1 0.259109
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 0.257652
GSX2 GS homeobox 2 0.252202
CABP1 calcium binding protein 1 0.251476
EXPH5 exophilin 5 0.250751
AGBL4 ATP/GTP binding protein-like 4 0.247492
MGAM maltase-glucoamylase 0.24713
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.24713
JAM3 junctional adhesion molecule 3 0.242076
BPI bactericidal/permeability-increasing protein 0.241356
CRCP CGRP receptor component 0.240276
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.239197
HYAL2 hyaluronoglucosaminidase 2 0.238119
GLIPR1 GLI pathogenesis-related 1 0.235607
C4B complement component 4B (Chido blood group) 0.234533
PRDX4 peroxiredoxin 4 0.233101
DNTT DNA nucleotidylexotransferase 0.232386
PLA2G10 phospholipase A2, group X 0.228819
GRK4 G protein-coupled receptor kinase 4 0.225267
TH tyrosine hydroxylase 0.221025
SPAG7 sperm associated antigen 7 0.220673
STX10 syntaxin 10 0.219969
STK17B serine/threonine kinase 17b 0.219617
GANC glucosidase, alpha; neutral C 0.218914
AGFG1 ArfGAP with FG repeats 1 0.21716
DUSP2 dual specificity phosphatase 2 0.21716
CLNK cytokine-dependent hematopoietic cell linker 0.21681
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.215063
SGMS2 sphingomyelin synthase 2 0.214017
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 0.212627
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.212627
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.21124
DBT dihydrolipoamide branched chain transacylase E2 0.210549
ITGA6 integrin, alpha 6 0.209858
PATE1 prostate and testis expressed 1 0.208825
AURKAIP1 aurora kinase A interacting protein 1 0.207794
SPEF2 sperm flagellar 2 0.206766
SRSF10 serine/arginine-rich splicing factor 10 0.20574
GSTA3 glutathione S-transferase alpha 3 0.201672
DAZL deleted in azoospermia-like 0.201335
GSTA2 glutathione S-transferase alpha 2 0.199993
GSTA4 glutathione S-transferase alpha 4 0.199993
GUSB glucuronidase, beta 0.198325
GSTA1 glutathione S-transferase alpha 1 0.197993
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.197662
PIGG phosphatidylinositol glycan anchor biosynthesis, class G 0.196999
SLIRP SRA stem-loop interacting RNA binding protein 0.194045
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.18796
TEKT2 tektin 2 (testicular) 0.187333
VDAC3 voltage-dependent anion channel 3 0.186397
ADGRG2 adhesion G protein-coupled receptor G2 0.185469
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.18516
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.184241
CATSPER2 cation channel, sperm associated 2 0.183631
MSMB microseminoprotein, beta- 0.182723
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.182422
PLG plasminogen 0.181823
SNAP23 synaptosomal-associated protein, 23kDa 0.178588
OSBP2 oxysterol binding protein 2 0.178588
MAEL maelstrom spermatogenic transposon silencer 0.175745
ACTB actin, beta 0.175745
INPP5J inositol polyphosphate-5-phosphatase J 0.175466
WFDC2 WAP four-disulfide core domain 2 0.175188
RAMP1 receptor (G protein-coupled) activity modifying protein 1 0.173273
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.171937
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.171149
DPP7 dipeptidyl-peptidase 7 0.169604
SLURP1 secreted LY6/PLAUR domain containing 1 0.168847
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.168847
MYO5A myosin VA (heavy chain 12, myoxin) 0.165932
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.164089
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.163865
WASH7P WAS protein family homolog 7 pseudogene 0.1632
PRAME preferentially expressed antigen in melanoma 0.162763
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.162763
HIST1H2BD histone cluster 1, H2bd 0.16233
HIST1H2BH histone cluster 1, H2bh 0.16233
HIST3H2BB histone cluster 3, H2bb 0.16233
HIST2H2BF histone cluster 2, H2bf 0.16233
HK1 hexokinase 1 0.162117
PLB1 phospholipase B1 0.161905
HIST1H2BF histone cluster 1, H2bf 0.161484
HIST1H2BC histone cluster 1, H2bc 0.161484
WASH6P WAS protein family homolog 6 pseudogene 0.161275
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.161068
CCM2 cerebral cavernous malformation 2 0.160863
HIST1H2BA histone cluster 1, H2ba 0.160863
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.160053
WASH1 WAS protein family homolog 1 0.159856
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.159658
KITLG KIT ligand 0.159462
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 0.159268
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.157943
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.157218
GLRA1 glycine receptor, alpha 1 0.156863
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.156863
ALPPL2 alkaline phosphatase, placental-like 2 0.156863
RHOB ras homolog family member B 0.156863
ALPL alkaline phosphatase, liver/bone/kidney 0.156513
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.156513
ALPP alkaline phosphatase, placental 0.156342