aconitine-7149 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the aconitine-7149 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ANKMY1 ankyrin repeat and MYND domain containing 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARL15 ADP-ribosylation factor-like 15
ARMCX2 armadillo repeat containing, X-linked 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BTN3A1 butyrophilin, subfamily 3, member A1
C7ORF43 chromosome 7 open reading frame 43
C9ORF156 chromosome 9 open reading frame 156
CCNG2 cyclin G2
CENPQ centromere protein Q
CHD7 chromodomain helicase DNA binding protein 7
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
E2F1 E2F transcription factor 1
EDRF1 erythroid differentiation regulatory factor 1
EEA1 early endosome antigen 1
EFNA1 ephrin-A1
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EMP1 epithelial membrane protein 1
ETV1 ets variant 1
EXOG endo/exonuclease (5'-3'), endonuclease G-like
FGF1 fibroblast growth factor 1 (acidic)
FGF13 fibroblast growth factor 13
FKBP10 FK506 binding protein 10, 65 kDa
FKBP5 FK506 binding protein 5
FOXO1 forkhead box O1
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJC1 gap junction protein, gamma 1, 45kDa
GK glycerol kinase
GPATCH2L G patch domain containing 2-like
H1F0 H1 histone family, member 0
H2AFX H2A histone family, member X
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3
HIST1H1D histone cluster 1, H1d
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IGFBP5 insulin-like growth factor binding protein 5
KIFC1 kinesin family member C1
KRIT1 KRIT1, ankyrin repeat containing
LDB1 LIM domain binding 1
LMNB1 lamin B1
LNPEP leucyl/cystinyl aminopeptidase
LRRC61 leucine rich repeat containing 61
MAPK8 mitogen-activated protein kinase 8
MARS methionyl-tRNA synthetase
MATN3 matrilin 3
MAX MYC associated factor X
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
MCM3AP minichromosome maintenance complex component 3 associated protein
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC3B mucin 3B, cell surface associated
MVK mevalonate kinase
NF1 neurofibromin 1
NPM3 nucleophosmin/nucleoplasmin 3
PBX2 pre-B-cell leukemia homeobox 2
PDAP1 PDGFA associated protein 1
PEX5 peroxisomal biogenesis factor 5
PHC1 polyhomeotic homolog 1 (Drosophila)
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLCD1 phospholipase C, delta 1
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
RAB31 RAB31, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAD23B RAD23 homolog B (S. cerevisiae)
RANGAP1 Ran GTPase activating protein 1
RFK riboflavin kinase
RNF170 ring finger protein 170
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RUNX3 runt-related transcription factor 3
S100A11 S100 calcium binding protein A11
S100A3 S100 calcium binding protein A3
SCARB2 scavenger receptor class B, member 2
SENP6 SUMO1/sentrin specific peptidase 6
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SHANK2 SH3 and multiple ankyrin repeat domains 2
SHROOM2 shroom family member 2
SKIL SKI-like proto-oncogene
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SMG7 SMG7 nonsense mediated mRNA decay factor
SOCS6 suppressor of cytokine signaling 6
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STK16 serine/threonine kinase 16
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TRAK1 trafficking protein, kinesin binding 1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF174 zinc finger protein 174
ZNF345 zinc finger protein 345

decreased expression

Symbol Name
ADAMTSL3 ADAMTS-like 3
ALPK1 alpha-kinase 1
ANAPC2 anaphase promoting complex subunit 2
APOLD1 apolipoprotein L domain containing 1
ATG4A autophagy related 4A, cysteine peptidase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAK1 BCL2-antagonist/killer 1
BBS1 Bardet-Biedl syndrome 1
BIRC3 baculoviral IAP repeat containing 3
BTBD2 BTB (POZ) domain containing 2
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CAPN5 calpain 5
CARD8 caspase recruitment domain family, member 8
CFAP44 cilia and flagella associated protein 44
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIR1 corepressor interacting with RBPJ, 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CNTNAP1 contactin associated protein 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTNNBIP1 catenin, beta interacting protein 1
DLK2 delta-like 2 homolog (Drosophila)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
EFCAB2 EF-hand calcium binding domain 2
ERF Ets2 repressor factor
ESRP2 epithelial splicing regulatory protein 2
ETNK2 ethanolamine kinase 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FANCF Fanconi anemia, complementation group F
FGD1 FYVE, RhoGEF and PH domain containing 1
FIG4 FIG4 phosphoinositide 5-phosphatase
FLCN folliculin
FSTL3 follistatin-like 3 (secreted glycoprotein)
GPR3 G protein-coupled receptor 3
HMHA1 histocompatibility (minor) HA-1
HOMER2 homer scaffolding protein 2
HOOK2 hook microtubule-tethering protein 2
IFI6 interferon, alpha-inducible protein 6
IREB2 iron-responsive element binding protein 2
KIAA0232 KIAA0232
KIAA0513 KIAA0513
KIAA0894 KIAA0894 protein
KIAA0895 KIAA0895
KLK6 kallikrein-related peptidase 6
KRT4 keratin 4, type II
LIG4 ligase IV, DNA, ATP-dependent
LOC100127972 uncharacterized LOC100127972
LOC730101 uncharacterized LOC730101
MAN2B2 mannosidase, alpha, class 2B, member 2
MED9 mediator complex subunit 9
MFSD10 major facilitator superfamily domain containing 10
MNS1 meiosis-specific nuclear structural 1
MOCOS molybdenum cofactor sulfurase
MON1B MON1 secretory trafficking family member B
NDRG4 NDRG family member 4
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NME5 NME/NM23 family member 5
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PBLD phenazine biosynthesis-like protein domain containing
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLD2 phospholipase D2
POLH polymerase (DNA directed), eta
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTK6 protein tyrosine kinase 6
PTPN14 protein tyrosine phosphatase, non-receptor type 14
RAB3A RAB3A, member RAS oncogene family
RBL1 retinoblastoma-like 1
RBM6 RNA binding motif protein 6
RNF126P1 ring finger protein 126 pseudogene 1
RPGR retinitis pigmentosa GTPase regulator
RPL13P5 ribosomal protein L13 pseudogene 5
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SETD1B SET domain containing 1B
SETD8 SET domain containing (lysine methyltransferase) 8
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SMA4 glucuronidase, beta pseudogene
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TEX40 testis expressed 40
TMEM121 transmembrane protein 121
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSKU tsukushi, small leucine rich proteoglycan
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZFP36 ZFP36 ring finger protein
ZNF34 zinc finger protein 34
ZNF350 zinc finger protein 350
ZNF408 zinc finger protein 408
ZNF770 zinc finger protein 770