aceclofenac-2117 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the aceclofenac-2117 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD8 abhydrolase domain containing 8
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALPK3 alpha-kinase 3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
APP amyloid beta (A4) precursor protein
ARHGAP24 Rho GTPase activating protein 24
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
B9D1 B9 protein domain 1
BIN1 bridging integrator 1
BMP4 bone morphogenetic protein 4
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C11ORF63 chromosome 11 open reading frame 63
C17ORF80 chromosome 17 open reading frame 80
CALD1 caldesmon 1
CASKIN2 CASK interacting protein 2
CAV2 caveolin 2
CEP290 centrosomal protein 290kDa
CISH cytokine inducible SH2-containing protein
CNR2 cannabinoid receptor 2 (macrophage)
CPT1A carnitine palmitoyltransferase 1A (liver)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CYLD cylindromatosis (turban tumor syndrome)
DCAKD dephospho-CoA kinase domain containing
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
EIF3M eukaryotic translation initiation factor 3, subunit M
FGF5 fibroblast growth factor 5
FNBP1 formin binding protein 1
FOXG1 forkhead box G1
GATA3 GATA binding protein 3
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HNMT histamine N-methyltransferase
HOOK1 hook microtubule-tethering protein 1
HOXD1 homeobox D1
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IL17RC interleukin 17 receptor C
IL1RAP interleukin 1 receptor accessory protein
ING1 inhibitor of growth family, member 1
ITFG2 integrin alpha FG-GAP repeat containing 2
KCTD14 potassium channel tetramerization domain containing 14
KIAA0141 KIAA0141
KIF1A kinesin family member 1A
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MBD2 methyl-CpG binding domain protein 2
MLYCD malonyl-CoA decarboxylase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MUC3B mucin 3B, cell surface associated
NME5 NME/NM23 family member 5
NOL12 nucleolar protein 12
NOTCH2 notch 2
NUMA1 nuclear mitotic apparatus protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCDHGB5 protocadherin gamma subfamily B, 5
PDE4DIP phosphodiesterase 4D interacting protein
PER3 period circadian clock 3
PHF3 PHD finger protein 3
PLK3 polo-like kinase 3
PRDM2 PR domain containing 2, with ZNF domain
PRRC2A proline-rich coiled-coil 2A
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RBL2 retinoblastoma-like 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RGS4 regulator of G-protein signaling 4
RNF6 ring finger protein (C3H2C3 type) 6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SARM1 sterile alpha and TIR motif containing 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCARB1 scavenger receptor class B, member 1
SFTPB surfactant protein B
SIRT6 sirtuin 6
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC44A4 solute carrier family 44, member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SOGA1 suppressor of glucose, autophagy associated 1
SOX12 SRY (sex determining region Y)-box 12
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STK17B serine/threonine kinase 17b
TLR2 toll-like receptor 2
TM2D1 TM2 domain containing 1
TMEM47 transmembrane protein 47
TRIM23 tripartite motif containing 23
TRIM29 tripartite motif containing 29
TTC30A tetratricopeptide repeat domain 30A
TTC39A tetratricopeptide repeat domain 39A
VAC14 Vac14 homolog (S. cerevisiae)
VASP vasodilator-stimulated phosphoprotein
VAV3 vav 3 guanine nucleotide exchange factor
WASF3 WAS protein family, member 3
WDR13 WD repeat domain 13
ZBTB43 zinc finger and BTB domain containing 43
ZC2HC1C zinc finger, C2HC-type containing 1C
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACYP2 acylphosphatase 2, muscle type
AHDC1 AT hook, DNA binding motif, containing 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMDHD2 amidohydrolase domain containing 2
ARRB2 arrestin, beta 2
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
AXIN1 axin 1
BCORL1 BCL6 corepressor-like 1
CAPN15 calpain 15
CARD8 caspase recruitment domain family, member 8
CCL20 chemokine (C-C motif) ligand 20
CGREF1 cell growth regulator with EF-hand domain 1
CLCN5 chloride channel, voltage-sensitive 5
CLEC2B C-type lectin domain family 2, member B
CLIC3 chloride intracellular channel 3
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CRYBB2P1 crystallin, beta B2 pseudogene 1
DCAF17 DDB1 and CUL4 associated factor 17
DEAF1 DEAF1 transcription factor
DMBT1 deleted in malignant brain tumors 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DUSP8 dual specificity phosphatase 8
ECM1 extracellular matrix protein 1
ERCC5 excision repair cross-complementation group 5
FABP4 fatty acid binding protein 4, adipocyte
FBXL7 F-box and leucine-rich repeat protein 7
GALK1 galactokinase 1
GALT galactose-1-phosphate uridylyltransferase
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRWD1 glutamate-rich WD repeat containing 1
HIST1H2AJ histone cluster 1, H2aj
HOXB9 homeobox B9
HOXC5 homeobox C5
HSF2BP heat shock transcription factor 2 binding protein
IL17RA interleukin 17 receptor A
ITGA10 integrin, alpha 10
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KLHL28 kelch-like family member 28
KPTN kaptin (actin binding protein)
KRT86 keratin 86, type II
KRT8P12 keratin 8 pseudogene 12
LOC257152 uncharacterized LOC257152
LRP2 low density lipoprotein receptor-related protein 2
LRRC20 leucine rich repeat containing 20
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAPK12 mitogen-activated protein kinase 12
MCMBP minichromosome maintenance complex binding protein
MFSD11 major facilitator superfamily domain containing 11
MICALL2 MICAL-like 2
MTMR12 myotubularin related protein 12
MYL5 myosin, light chain 5, regulatory
NCS1 neuronal calcium sensor 1
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OASL 2'-5'-oligoadenylate synthetase-like
ORAI3 ORAI calcium release-activated calcium modulator 3
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PC pyruvate carboxylase
PID1 phosphotyrosine interaction domain containing 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
POLH polymerase (DNA directed), eta
PRMT7 protein arginine methyltransferase 7
RAB4B RAB4B, member RAS oncogene family
RBMS3 RNA binding motif, single stranded interacting protein 3
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN1 Ras and Rab interactor 1
SAMD9 sterile alpha motif domain containing 9
SCARA3 scavenger receptor class A, member 3
SEPP1 selenoprotein P, plasma, 1
SFXN1 sideroflexin 1
SIRT2 sirtuin 2
SIX1 SIX homeobox 1
SLC12A8 solute carrier family 12, member 8
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SPATA2L spermatogenesis associated 2-like
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM7SF2 transmembrane 7 superfamily member 2
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TOM1 target of myb1 (chicken)
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1
TRAIP TRAF interacting protein
TUBA3C tubulin, alpha 3c
TUBA3D tubulin, alpha 3d
ZBTB3 zinc finger and BTB domain containing 3
ZNF124 zinc finger protein 124
ZNF137P zinc finger protein 137, pseudogene
ZNF606 zinc finger protein 606
ZNF671 zinc finger protein 671
ZSCAN26 zinc finger and SCAN domain containing 26