absent spleen germinal center Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs (Mammalian Phenotype Ontology, MP_0008474)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008474
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Genes

22 gene mutations causing the absent spleen germinal center phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
CD19 CD19 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD86 CD86 molecule
CXCR5 chemokine (C-X-C motif) receptor 5
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IL2RG interleukin 2 receptor, gamma
IRF4 interferon regulatory factor 4
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
POU2AF1 POU class 2 associating factor 1
SHARPIN SHANK-associated RH domain interactor
SOCS1 suppressor of cytokine signaling 1
TNF tumor necrosis factor
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2