absent mesoderm Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities (Mammalian Phenotype Ontology, MP_0001683)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001683
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Genes

59 gene mutations causing the absent mesoderm phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
AMN amnion associated transmembrane protein
ARC activity-regulated cytoskeleton-associated protein
ARID1A AT rich interactive domain 1A (SWI-like)
BMP5 bone morphogenetic protein 5
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
CHD8 chromodomain helicase DNA binding protein 8
CHRD chordin
COPS3 COP9 signalosome subunit 3
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
ECSIT ECSIT signalling integrator
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELF5 E74-like factor 5 (ets domain transcription factor)
EOMES eomesodermin
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FOXA2 forkhead box A2
FOXD3 forkhead box D3
GCLC glutamate-cysteine ligase, catalytic subunit
GDF3 growth differentiation factor 3
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
HNF4A hepatocyte nuclear factor 4, alpha
MACF1 microtubule-actin crosslinking factor 1
MESDC2 mesoderm development candidate 2
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
METAP2 methionyl aminopeptidase 2
MYL1 myosin, light chain 1, alkali; skeletal, fast
NF2 neurofibromin 2 (merlin)
NFE2L1 nuclear factor, erythroid 2-like 1
NSD1 nuclear receptor binding SET domain protein 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKNOX1 PBX/knotted 1 homeobox 1
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRICKLE1 prickle homolog 1 (Drosophila)
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
SLC31A1 solute carrier family 31 (copper transporter), member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TDGF1 teratocarcinoma-derived growth factor 1
TENM4 teneurin transmembrane protein 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TJP2 tight junction protein 2
TRIM28 tripartite motif containing 28
TSG101 tumor susceptibility 101
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1