absent germinal center b cells Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen (Mammalian Phenotype Ontology, MP_0008179)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008179
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Genes

5 gene mutations causing the absent germinal center b cells phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BATF basic leucine zipper transcription factor, ATF-like
CD40 CD40 molecule, TNF receptor superfamily member 5
LTB lymphotoxin beta (TNF superfamily, member 3)
TNF tumor necrosis factor