absent follicular dendritic cells Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response (Mammalian Phenotype Ontology, MP_0008201)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0008201
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Genes

8 gene mutations causing the absent follicular dendritic cells phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
CXCL13 chemokine (C-X-C motif) ligand 13
CXCR5 chemokine (C-X-C motif) receptor 5
IGHM immunoglobulin heavy constant mu
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MAP3K14 mitogen-activated protein kinase kinase kinase 14
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A