abnormal type i hypersensitivity reaction Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly in a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks (Mammalian Phenotype Ontology, MP_0002531)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002531
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Genes

69 gene mutations causing the abnormal type i hypersensitivity reaction phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2B adenosine A2b receptor
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
C3AR1 complement component 3a receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CCRL2 chemokine (C-C motif) receptor-like 2
CD28 CD28 molecule
CD300LF CD300 molecule-like family member f
CD81 CD81 molecule
CISH cytokine inducible SH2-containing protein
CPA3 carboxypeptidase A3 (mast cell)
CYSLTR1 cysteinyl leukotriene receptor 1
CYSLTR2 cysteinyl leukotriene receptor 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
ECM1 extracellular matrix protein 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23)
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
HPGDS hematopoietic prostaglandin D synthase
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL13 interleukin 13
IL25 interleukin 25
IL4R interleukin 4 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LBP lipopolysaccharide binding protein
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LPAR2 lysophosphatidic acid receptor 2
LTA4H leukotriene A4 hydrolase
LTB4R leukotriene B4 receptor
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
MILR1 mast cell immunoglobulin-like receptor 1
MME membrane metallo-endopeptidase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
ORAI1 ORAI calcium release-activated calcium modulator 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G3 phospholipase A2, group III
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PTAFR platelet-activating factor receptor
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGES prostaglandin E synthase
PTGES2 prostaglandin E synthase 2
PTPRC protein tyrosine phosphatase, receptor type, C
RGS13 regulator of G-protein signaling 13
RGS3 regulator of G-protein signaling 3
RHOH ras homolog family member H
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
STIM1 stromal interaction molecule 1
STXBP2 syntaxin binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBXA2R thromboxane A2 receptor
TICAM1 toll-like receptor adaptor molecule 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TRPM4 transient receptor potential cation channel, subfamily M, member 4
VAMP8 vesicle-associated membrane protein 8
VIPR2 vasoactive intestinal peptide receptor 2