abnormal trophoblast layer morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any structural anomaly of the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta (Mammalian Phenotype Ontology, MP_0005031)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005031
Similar Terms
Downloads & Tools

Genes

132 gene mutations causing the abnormal trophoblast layer morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ASCL2 achaete-scute family bHLH transcription factor 2
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BIRC6 baculoviral IAP repeat containing 6
BMP5 bone morphogenetic protein 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
C3 complement component 3
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK7 cyclin-dependent kinase 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
CHM choroideremia (Rab escort protein 1)
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
COMT catechol-O-methyltransferase
COPS2 COP9 signalosome subunit 2
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSNK2B casein kinase 2, beta polypeptide
CUL3 cullin 3
CUL7 cullin 7
DLK1 delta-like 1 homolog (Drosophila)
DLX3 distal-less homeobox 3
DNM1L dynamin 1-like
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
DUSP9 dual specificity phosphatase 9
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EOMES eomesodermin
EPCAM epithelial cell adhesion molecule
ERF Ets2 repressor factor
ERN1 endoplasmic reticulum to nucleus signaling 1
ERVFRD-1 endogenous retrovirus group FRD, member 1
ESRRB estrogen-related receptor beta
ESX1 ESX homeobox 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBXO5 F-box protein 5
FBXW8 F-box and WD repeat domain containing 8
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FOXD3 forkhead box D3
FRS2 fibroblast growth factor receptor substrate 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G6PD glucose-6-phosphate dehydrogenase
GAB1 GRB2-associated binding protein 1
GCM1 glial cells missing homolog 1 (Drosophila)
GJB3 gap junction protein, beta 3, 31kDa
GJB5 gap junction protein, beta 5, 31.1kDa
HAND1 heart and neural crest derivatives expressed 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSF1 heat shock transcription factor 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IL11RA interleukin 11 receptor, alpha
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
JUP junction plakoglobin
KDM6A lysine (K)-specific demethylase 6A
KRT8 keratin 8, type II
LAMA5 laminin, alpha 5
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MDFI MyoD family inhibitor
MED1 mediator complex subunit 1
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MPI mannose phosphate isomerase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH9 myosin, heavy chain 9, non-muscle
NCOA6 nuclear receptor coactivator 6
NOA1 nitric oxide associated 1
NODAL nodal growth differentiation factor
NRK Nik related kinase
NUMB numb homolog (Drosophila)
PBRM1 polybromo 1
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC1 placenta-specific 1
PMM2 phosphomannomutase 2
PNPLA6 patatin-like phospholipase domain containing 6
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPARG peroxisome proliferator-activated receptor gamma
PRDM1 PR domain containing 1, with ZNF domain
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAD23B RAD23 homolog B (S. cerevisiae)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RECQL4 RecQ protein-like 4
RPTOR regulatory associated protein of MTOR, complex 1
RTEL1 regulator of telomere elongation helicase 1
RTL1 retrotransposon-like 1
RYBP RING1 and YY1 binding protein
SALL4 spalt-like transcription factor 4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNX13 sorting nexin 13
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SP3 Sp3 transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSB Sjogren syndrome antigen B (autoantigen La)
STK11 serine/threonine kinase 11
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TEAD4 TEA domain family member 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
THBD thrombomodulin
TLN1 talin 1
TRRAP transformation/transcription domain-associated protein
TTPA tocopherol (alpha) transfer protein
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZFAT zinc finger and AT hook domain containing
ZFP36L1 ZFP36 ring finger protein-like 1
ZPR1 ZPR1 zinc finger