abnormal trophoblast giant cells Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta (Mammalian Phenotype Ontology, MP_0005033)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005033
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Genes

72 gene mutations causing the abnormal trophoblast giant cells phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARNT aryl hydrocarbon receptor nuclear translocator
AURKB aurora kinase B
BIRC5 baculoviral IAP repeat containing 5
BMP5 bone morphogenetic protein 5
BRCA1 breast cancer 1, early onset
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDX2 caudal type homeobox 2
COPS2 COP9 signalosome subunit 2
CSNK2B casein kinase 2, beta polypeptide
CUL3 cullin 3
CUL7 cullin 7
DNM1L dynamin 1-like
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELAVL1 ELAV like RNA binding protein 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EOMES eomesodermin
EPCAM epithelial cell adhesion molecule
ERF Ets2 repressor factor
ESRRB estrogen-related receptor beta
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FRS2 fibroblast growth factor receptor substrate 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GAB1 GRB2-associated binding protein 1
HAND1 heart and neural crest derivatives expressed 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IL11RA interleukin 11 receptor, alpha
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB7 integrin, beta 7
KDM6A lysine (K)-specific demethylase 6A
KRT8 keratin 8, type II
MAPK14 mitogen-activated protein kinase 14
MDFI MyoD family inhibitor
MED1 mediator complex subunit 1
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NCOA6 nuclear receptor coactivator 6
NODAL nodal growth differentiation factor
PBRM1 polybromo 1
PLAC1 placenta-specific 1
PMM2 phosphomannomutase 2
PNPLA6 patatin-like phospholipase domain containing 6
PPARG peroxisome proliferator-activated receptor gamma
PRDM1 PR domain containing 1, with ZNF domain
RECQL4 RecQ protein-like 4
RPTOR regulatory associated protein of MTOR, complex 1
RTEL1 regulator of telomere elongation helicase 1
RYBP RING1 and YY1 binding protein
SALL4 spalt-like transcription factor 4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNX13 sorting nexin 13
SOCS3 suppressor of cytokine signaling 3
SOX2 SRY (sex determining region Y)-box 2
SPINT1 serine peptidase inhibitor, Kunitz type 1
SSB Sjogren syndrome antigen B (autoantigen La)
TEAD4 TEA domain family member 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
THBD thrombomodulin
TRRAP transformation/transcription domain-associated protein
TTPA tocopherol (alpha) transfer protein
TXNRD1 thioredoxin reductase 1
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZPR1 ZPR1 zinc finger