abnormal triploblastic development Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description abnormal development of the three primary germ layers of the embryo (Mammalian Phenotype Ontology, MP_0001674)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001674
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Genes

195 gene mutations causing the abnormal triploblastic development phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR1 activin A receptor, type I
ACVR1B activin A receptor, type IB
ADAM10 ADAM metallopeptidase domain 10
AMN amnion associated transmembrane protein
APC adenomatous polyposis coli
APH1A APH1A gamma secretase subunit
ARC activity-regulated cytoskeleton-associated protein
ARID1A AT rich interactive domain 1A (SWI-like)
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
BMP4 bone morphogenetic protein 4
BMP5 bone morphogenetic protein 5
BMP7 bone morphogenetic protein 7
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
CHD8 chromodomain helicase DNA binding protein 8
CHRD chordin
CHUK conserved helix-loop-helix ubiquitous kinase
CLUAP1 clusterin associated protein 1
COL2A1 collagen, type II, alpha 1
COPS3 COP9 signalosome subunit 3
CRB2 crumbs family member 2
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUBN cubilin (intrinsic factor-cobalamin receptor)
CUL1 cullin 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAD1 defender against cell death 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAXX death-domain associated protein
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLL1 delta-like 1 (Drosophila)
DLL3 delta-like 3 (Drosophila)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DSP desmoplakin
E4F1 E4F transcription factor 1
ECSIT ECSIT signalling integrator
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
ELF5 E74-like factor 5 (ets domain transcription factor)
EN1 engrailed homeobox 1
EOMES eomesodermin
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA2 EPH receptor A2
EXOC4 exocyst complex component 4
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FERMT2 fermitin family member 2
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FLCN folliculin
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FNTB farnesyltransferase, CAAX box, beta
FOXA2 forkhead box A2
FOXD3 forkhead box D3
FOXF1 forkhead box F1
FOXH1 forkhead box H1
FUZ fuzzy planar cell polarity protein
G6PD glucose-6-phosphate dehydrogenase
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GCLC glutamate-cysteine ligase, catalytic subunit
GDF3 growth differentiation factor 3
GLI3 GLI family zinc finger 3
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1
GPR161 G protein-coupled receptor 161
GPX4 glutathione peroxidase 4
GRB2 growth factor receptor-bound protein 2
GREM1 gremlin 1, DAN family BMP antagonist
HAND1 heart and neural crest derivatives expressed 1
HAND2 heart and neural crest derivatives expressed 2
HIRA histone cell cycle regulator
HNF1B HNF1 homeobox B
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSBP1 heat shock factor binding protein 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HTT huntingtin
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IFT172 intraflagellar transport 172
ISL1 ISL LIM homeobox 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JAG2 jagged 2
KAT2A K(lysine) acetyltransferase 2A
KIF3A kinesin family member 3A
KMT2A lysine (K)-specific methyltransferase 2A
LEFTY2 left-right determination factor 2
LHX1 LIM homeobox 1
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
MACF1 microtubule-actin crosslinking factor 1
MAX MYC associated factor X
MBTPS1 membrane-bound transcription factor peptidase, site 1
MECOM MDS1 and EVI1 complex locus
MESDC2 mesoderm development candidate 2
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2
METAP2 methionyl aminopeptidase 2
MIB1 mindbomb E3 ubiquitin protein ligase 1
MIXL1 Mix paired-like homeobox
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MSGN1 mesogenin 1
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYH9 myosin, heavy chain 9, non-muscle
MYL1 myosin, light chain 1, alkali; skeletal, fast
NCKAP1 NCK-associated protein 1
NF2 neurofibromin 2 (merlin)
NFE2L1 nuclear factor, erythroid 2-like 1
NODAL nodal growth differentiation factor
NR5A2 nuclear receptor subfamily 5, group A, member 2
NSD1 nuclear receptor binding SET domain protein 1
NUP133 nucleoporin 133kDa
OTX2 orthodenticle homeobox 2
OVOL2 ovo-like zinc finger 2
PALB2 partner and localizer of BRCA2
PAX2 paired box 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PELO pelota homolog (Drosophila)
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PISD phosphatidylserine decarboxylase
PITX2 paired-like homeodomain 2
PKNOX1 PBX/knotted 1 homeobox 1
POFUT2 protein O-fucosyltransferase 2
POGLUT1 protein O-glucosyltransferase 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRICKLE1 prickle homolog 1 (Drosophila)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCI protein kinase C, iota
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD51 RAD51 recombinase
RANGAP1 Ran GTPase activating protein 1
RDH10 retinol dehydrogenase 10 (all-trans)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RNF2 ring finger protein 2
RSPO2 R-spondin 2
RTEL1 regulator of telomere elongation helicase 1
SALL4 spalt-like transcription factor 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SKI SKI proto-oncogene
SLC31A1 solute carrier family 31 (copper transporter), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SNAI1 snail family zinc finger 1
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SP8 Sp8 transcription factor
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRF serum response factor (c-fos serum response element-binding transcription factor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
T T, brachyury homolog (mouse)
TAL1 T-cell acute lymphocytic leukemia 1
TBX3 T-box 3
TBX6 T-box 6
TCF15 transcription factor 15 (basic helix-loop-helix)
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TDGF1 teratocarcinoma-derived growth factor 1
TENM4 teneurin transmembrane protein 4
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TJP2 tight junction protein 2
TLN1 talin 1
TLX2 T-cell leukemia homeobox 2
TP63 tumor protein p63
TPT1 tumor protein, translationally-controlled 1
TRIM28 tripartite motif containing 28
TRIM33 tripartite motif containing 33
TSG101 tumor susceptibility 101
TSIX TSIX transcript, XIST antisense RNA
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
UHRF1 ubiquitin-like with PHD and ring finger domains 1
VCL vinculin
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WASL Wiskott-Aldrich syndrome-like
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
WNT5A wingless-type MMTV integration site family, member 5A
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZBTB17 zinc finger and BTB domain containing 17
ZIC3 Zic family member 3