abnormal triglyceride level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description any anomaly in the concentration of triglyceride, a glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue (Mammalian Phenotype Ontology, MP_0000187)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000187
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Genes

325 gene mutations causing the abnormal triglyceride level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ABHD5 abhydrolase domain containing 5
ACACB acetyl-CoA carboxylase beta
ACOT11 acyl-CoA thioesterase 11
ACOT13 acyl-CoA thioesterase 13
ADCY10 adenylate cyclase 10 (soluble)
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADGRG6 adhesion G protein-coupled receptor G6
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
AEBP1 AE binding protein 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGRP agouti related neuropeptide
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALDH16A1 aldehyde dehydrogenase 16 family, member A1
ALMS1 Alstrom syndrome protein 1
ALPI alkaline phosphatase, intestinal
AMACR alpha-methylacyl-CoA racemase
ANGPTL3 angiopoietin-like 3
ANGPTL4 angiopoietin-like 4
ANKRD26 ankyrin repeat domain 26
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOF apolipoprotein F
APOM apolipoprotein M
AQP3 aquaporin 3 (Gill blood group)
AQP8 aquaporin 8
AQP9 aquaporin 9
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARRDC3 arrestin domain containing 3
BAG3 BCL2-associated athanogene 3
BCO2 beta-carotene oxygenase 2
BGLAP bone gamma-carboxyglutamate (gla) protein
BHMT betaine--homocysteine S-methyltransferase
BRD2 bromodomain containing 2
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
C19ORF80 chromosome 19 open reading frame 80
C3 complement component 3
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAPZB capping protein (actin filament) muscle Z-line, beta
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX6 chromobox homolog 6
CD36 CD36 molecule (thrombospondin receptor)
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEP19 centrosomal protein 19kDa
CES1 carboxylesterase 1
CHKA choline kinase alpha
CHRM3 cholinergic receptor, muscarinic 3
CIDEA cell death-inducing DFFA-like effector a
CIDEB cell death-inducing DFFA-like effector b
CIDEC cell death-inducing DFFA-like effector c
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
CLPS colipase, pancreatic
CNOT3 CCR4-NOT transcription complex, subunit 3
COL18A1 collagen, type XVIII, alpha 1
CPE carboxypeptidase E
CPT1C carnitine palmitoyltransferase 1C
CRBN cereblon
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRHR2 corticotropin releasing hormone receptor 2
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CXCL14 chemokine (C-X-C motif) ligand 14
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DGAT1 diacylglycerol O-acyltransferase 1
DGAT2 diacylglycerol O-acyltransferase 2
DLL1 delta-like 1 (Drosophila)
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
ECI1 enoyl-CoA delta isomerase 1
EGR1 early growth response 1
ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)
ELMOD1 ELMO/CED-12 domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERCC1 excision repair cross-complementation group 1
FABP1 fatty acid binding protein 1, liver
FABP3 fatty acid binding protein 3, muscle and heart
FABP4 fatty acid binding protein 4, adipocyte
FABP6 fatty acid binding protein 6, ileal
FADS2 fatty acid desaturase 2
FAM117B family with sequence similarity 117, member B
FFAR1 free fatty acid receptor 1
FFAR3 free fatty acid receptor 3
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FOXA1 forkhead box A1
FOXA2 forkhead box A2
FOXO1 forkhead box O1
FTO fat mass and obesity associated
G0S2 G0/G1 switch 2
G6PC glucose-6-phosphatase, catalytic subunit
G6PC2 glucose-6-phosphatase, catalytic, 2
GALC galactosylceramidase
GALR3 galanin receptor 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCGR glucagon receptor
GCK glucokinase (hexokinase 4)
GHR growth hormone receptor
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
GPAM glycerol-3-phosphate acyltransferase, mitochondrial
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GPR12 G protein-coupled receptor 12
GPR26 G protein-coupled receptor 26
GPRC6A G protein-coupled receptor, class C, group 6, member A
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D
GSTK1 glutathione S-transferase kappa 1
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HADH hydroxyacyl-CoA dehydrogenase
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HNF4A hepatocyte nuclear factor 4, alpha
HPN hepsin
HRH1 histamine receptor H1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL21R interleukin 21 receptor
IL25 interleukin 25
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
INS insulin
INSIG1 insulin induced gene 1
INSR insulin receptor
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
JAK1 Janus kinase 1
JUND jun D proto-oncogene
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KDM3A lysine (K)-specific demethylase 3A
KISS1R KISS1 receptor
KLB klotho beta
KMT2B lysine (K)-specific methyltransferase 2B
LAMB2 laminin, beta 2 (laminin S)
LCAT lecithin-cholesterol acyltransferase
LDLR low density lipoprotein receptor
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LEP leptin
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LIF leukemia inhibitory factor
LIPA lipase A, lysosomal acid, cholesterol esterase
LIPC lipase, hepatic
LIPE lipase, hormone-sensitive
LIPG lipase, endothelial
LIPI lipase, member I
LMF1 lipase maturation factor 1
LMNA lamin A/C
LPIN1 lipin 1
LPL lipoprotein lipase
LRP6 low density lipoprotein receptor-related protein 6
LYPD3 LY6/PLAUR domain containing 3
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MFSD2A major facilitator superfamily domain containing 2A
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MGLL monoglyceride lipase
MIA2 melanoma inhibitory activity 2
MIR122 microRNA 122
MIR378A microRNA 378a
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
MTTP microsomal triglyceride transfer protein
MUC2 mucin 2, oligomeric mucus/gel-forming
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NCOA6 nuclear receptor coactivator 6
NEGR1 neuronal growth regulator 1
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NKX2-3 NK2 homeobox 3
NMU neuromedin U
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPC1L1 NPC1-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1D1 nuclear receptor subfamily 1, group D, member 1
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR2C2 nuclear receptor subfamily 2, group C, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUAK2 NUAK family, SNF1-like kinase, 2
NXPH4 neurexophilin 4
OCA2 oculocutaneous albinism II
OED Oregon eye disease
OMA1 OMA1 zinc metallopeptidase
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSBPL8 oxysterol binding protein-like 8
OSMR oncostatin M receptor
OSTM1 osteopetrosis associated transmembrane protein 1
PANK1 pantothenate kinase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PEX11A peroxisomal biogenesis factor 11 alpha
PHYH phytanoyl-CoA 2-hydroxylase
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PITPNA phosphatidylinositol transfer protein, alpha
PITX3 paired-like homeodomain 3
PLA2G12B phospholipase A2, group XIIB
PLAGL2 pleiomorphic adenoma gene-like 2
PLIN2 perilipin 2
PLIN4 perilipin 4
PLIN5 perilipin 5
PLSCR3 phospholipid scramblase 3
PLVAP plasmalemma vesicle associated protein
PMCH pro-melanin-concentrating hormone
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRF1 perforin 1 (pore forming protein)
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRKG1 protein kinase, cGMP-dependent, type I
PRLH prolactin releasing hormone
PROX1 prospero homeobox 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTRF polymerase I and transcript release factor
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RETN resistin
RGN regucalcin
RNF10 ring finger protein 10
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RSBN1 round spermatid basic protein 1
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCP2 sterol carrier protein 2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERTAD2 SERTA domain containing 2
SESN2 sestrin 2
SGMS2 sphingomyelin synthase 2
SGOL2 shugoshin-like 2 (S. pombe)
SIK3 SIK family kinase 3
SIRT3 sirtuin 3
SIRT7 sirtuin 7
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC38A10 solute carrier family 38, member 10
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC51A solute carrier family 51, alpha subunit
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10
SOAT2 sterol O-acyltransferase 2
SOCS2 suppressor of cytokine signaling 2
SORBS1 sorbin and SH3 domain containing 1
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
SREBF1 sterol regulatory element binding transcription factor 1
SSFA2 sperm specific antigen 2
STARD10 StAR-related lipid transfer (START) domain containing 10
STEAP4 STEAP family member 4
THRB thyroid hormone receptor, beta
THRSP thyroid hormone responsive
TLR4 toll-like receptor 4
TLR5 toll-like receptor 5
TMEM167A transmembrane protein 167A
TNF tumor necrosis factor
TRA2B transformer 2 beta homolog (Drosophila)
TRPC2 transient receptor potential cation channel, subfamily C, member 2, pseudogene
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TUB tubby bipartite transcription factor
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
UMOD uromodulin
USH1C Usher syndrome 1C (autosomal recessive, severe)
USHBP1 Usher syndrome 1C binding protein 1
VLDLR very low density lipoprotein receptor
WRN Werner syndrome, RecQ helicase-like
WWOX WW domain containing oxidoreductase
XDH xanthine dehydrogenase
ZEB1 zinc finger E-box binding homeobox 1