abnormal tooth morphology Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description atypical size, shape or hard tissue structure of the teeth (Mammalian Phenotype Ontology, MP_0002100)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0002100
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Genes

153 gene mutations causing the abnormal tooth morphology phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR2A activin A receptor, type IIA
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKAP9 A kinase (PRKA) anchor protein 9
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALPL alkaline phosphatase, liver/bone/kidney
AMBN ameloblastin (enamel matrix protein)
AMELY amelogenin, Y-linked
ANKH ANKH inorganic pyrophosphate transport regulator
ANTXR1 anthrax toxin receptor 1
BARX1 BARX homeobox 1
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BBX bobby sox homolog (Drosophila)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BMP7 bone morphogenetic protein 7
CCL13 chemokine (C-C motif) ligand 13
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDON cell adhesion associated, oncogene regulated
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
CHUK conserved helix-loop-helix ubiquitous kinase
CLCN5 chloride channel, voltage-sensitive 5
CLCN7 chloride channel, voltage-sensitive 7
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSRP2BP CSRP2 binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSK cathepsin K
CTSV cathepsin V
DCN decorin
DISP1 dispatched homolog 1 (Drosophila)
DLX5 distal-less homeobox 5
DMP1 dentin matrix acidic phosphoprotein 1
DSPP dentin sialophosphoprotein
EDA ectodysplasin A
EDAR ectodysplasin A receptor
EDARADD EDAR-associated death domain
ENAM enamelin
EVC Ellis van Creveld protein
EXOC3L2 exocyst complex component 3-like 2
FAM20A family with sequence similarity 20, member A
FAM20C family with sequence similarity 20, member C
FAM73B family with sequence similarity 73, member B
FCGBP Fc fragment of IgG binding protein
FGF10 fibroblast growth factor 10
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FIG4 FIG4 phosphoinositide 5-phosphatase
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXA2 forkhead box A2
FST follistatin
FUZ fuzzy planar cell polarity protein
GJA1 gap junction protein, alpha 1, 43kDa
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
HHAT hedgehog acyltransferase
HOXB1 homeobox B1
HOXB8 homeobox B8
IDUA iduronidase, alpha-L-
IFT27 intraflagellar transport 27
IFT88 intraflagellar transport 88
IL1R1 interleukin 1 receptor, type I
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ITGA11 integrin, alpha 11
KDM4B lysine (K)-specific demethylase 4B
KLK4 kallikrein-related peptidase 4
LAMA3 laminin, alpha 3
LAMA5 laminin, alpha 5
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LEF1 lymphoid enhancer-binding factor 1
LMNA lamin A/C
LPAR1 lysophosphatidic acid receptor 1
LRP4 low density lipoprotein receptor-related protein 4
LRP6 low density lipoprotein receptor-related protein 6
LTBP1 latent transforming growth factor beta binding protein 1
LTBP3 latent transforming growth factor beta binding protein 3
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MECP2 methyl CpG binding protein 2
MITF microphthalmia-associated transcription factor
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP20 matrix metallopeptidase 20
MSX1 msh homeobox 1
MSX2 msh homeobox 2
MTF2 metal response element binding transcription factor 2
NF2 neurofibromin 2 (merlin)
NFE2L2 nuclear factor, erythroid 2-like 2
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
NGFR nerve growth factor receptor
NKX2-3 NK2 homeobox 3
NOS2 nitric oxide synthase 2, inducible
NPHP3 nephronophthisis 3 (adolescent)
NPR2 natriuretic peptide receptor 2
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
OSR2 odd-skipped related transciption factor 2
OSTM1 osteopetrosis associated transmembrane protein 1
PAX9 paired box 9
PC pyruvate carboxylase
PITX2 paired-like homeodomain 2
POSTN periostin, osteoblast specific factor
POU1F1 POU class 1 homeobox 1
PTCH1 patched 1
PTHLH parathyroid hormone-like hormone
PTPN9 protein tyrosine phosphatase, non-receptor type 9
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
PVRL3 poliovirus receptor-related 3
RECQL4 RecQ protein-like 4
RHOBTB3 Rho-related BTB domain containing 3
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RSPO2 R-spondin 2
RUNX2 runt-related transcription factor 2
SATB2 SATB homeobox 2
SETD5 SET domain containing 5
SH3PXD2B SH3 and PX domains 2B
SIM2 single-minded family bHLH transcription factor 2
SIRT1 sirtuin 1
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC39A13 solute carrier family 39 (zinc transporter), member 13
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLX4 SLX4 structure-specific endonuclease subunit
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SOSTDC1 sclerostin domain containing 1
SOX3 SRY (sex determining region Y)-box 3
SP3 Sp3 transcription factor
SP6 Sp6 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPI1 Spi-1 proto-oncogene
SPRY2 sprouty homolog 2 (Drosophila)
SPRY4 sprouty homolog 4 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAG1 stromal antigen 1
TBX1 T-box 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TGFB1 transforming growth factor, beta 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP63 tumor protein p63
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBE3B ubiquitin protein ligase E3B
UROS uroporphyrinogen III synthase
VAX1 ventral anterior homeobox 1
VEGFA vascular endothelial growth factor A
ZIC5 Zic family member 5
ZMPSTE24 zinc metallopeptidase STE24