abnormal systemic arterial blood pressure Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description altered tension of the blood within the systemic arteries (Mammalian Phenotype Ontology, MP_0000230)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000230
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Genes

194 gene mutations causing the abnormal systemic arterial blood pressure phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACE angiotensin I converting enzyme
ACE2 angiotensin I converting enzyme 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD2 adducin 2 (beta)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA2A adenosine A2a receptor
ADORA2B adenosine A2b receptor
ADORA3 adenosine A3 receptor
ADRA1A adrenoceptor alpha 1A
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
ADRA2A adrenoceptor alpha 2A
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AGTRAP angiotensin II receptor-associated protein
AGXT2 alanine--glyoxylate aminotransferase 2
ALOX15 arachidonate 15-lipoxygenase
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APLNR apelin receptor
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARL6 ADP-ribosylation factor-like 6
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARSB arylsulfatase B
ASL argininosuccinate lyase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AVPR1A arginine vasopressin receptor 1A
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BRS3 bombesin-like receptor 3
BSND barttin CLCNK-type chloride channel accessory beta subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CALCB calcitonin-related polypeptide beta
CAV1 caveolin 1, caveolae protein, 22kDa
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHGA chromogranin A
CKM creatine kinase, muscle
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)
CLEC1B C-type lectin domain family 1, member B
COL3A1 collagen, type III, alpha 1
COMT catechol-O-methyltransferase
CORIN corin, serine peptidase
CRHR2 corticotropin releasing hormone receptor 2
CTH cystathionine gamma-lyase
CTSA cathepsin A
CYBB cytochrome b-245, beta polypeptide
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11
DDAH1 dimethylarginine dimethylaminohydrolase 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLL1 delta-like 1 (Drosophila)
DNM1L dynamin 1-like
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD5 dopamine receptor D5
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EDNRB endothelin receptor type B
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
ELN elastin
EPHX2 epoxide hydrolase 2, cytoplasmic
ESR2 estrogen receptor 2 (ER beta)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBLN5 fibulin 5
FGF2 fibroblast growth factor 2 (basic)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GDNF glial cell derived neurotrophic factor
GHR growth hormone receptor
GJA5 gap junction protein, alpha 5, 40kDa
GLA galactosidase, alpha
GNAS GNAS complex locus
GPER1 G protein-coupled estrogen receptor 1
GPSM1 G-protein signaling modulator 1
GSE1 Gse1 coiled-coil protein
GUCA2B guanylate cyclase activator 2B (uroguanylin)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HCRT hypocretin (orexin) neuropeptide precursor
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRAS Harvey rat sarcoma viral oncogene homolog
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
IDUA iduronidase, alpha-L-
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHMBP2 immunoglobulin mu binding protein 2
IL10 interleukin 10
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KCNK6 potassium channel, two pore domain subfamily K, member 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KLF3 Kruppel-like factor 3 (basic)
KRAS Kirsten rat sarcoma viral oncogene homolog
LEP leptin
LEPR leptin receptor
LRRK2 leucine-rich repeat kinase 2
MKKS McKusick-Kaufman syndrome
MPV17 MpV17 mitochondrial inner membrane protein
MRVI1 murine retrovirus integration site 1 homolog
MUS81 MUS81 structure-specific endonuclease subunit
MYH11 myosin, heavy chain 11, smooth muscle
NCALD neurocalcin delta
NCF1 neutrophil cytosolic factor 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX1 NADPH oxidase 1
NPAS2 neuronal PAS domain protein 2
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NPR3 natriuretic peptide receptor 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OXSR1 oxidative stress responsive 1
OXT oxytocin/neurophysin I prepropeptide
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK2 proprotein convertase subtilisin/kexin type 2
PDC phosducin
PNMT phenylethanolamine N-methyltransferase
PODXL podocalyxin-like
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PRKG1 protein kinase, cGMP-dependent, type I
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAMP2 receptor (G protein-coupled) activity modifying protein 2
REN renin
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RNLS renalase, FAD-dependent amine oxidase
RORA RAR-related orphan receptor A
SCNN1B sodium channel, non voltage gated 1 beta subunit
SIRT3 sirtuin 3
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SMAD6 SMAD family member 6
SMTN smoothelin
SOX13 SRY (sex determining region Y)-box 13
SPP1 secreted phosphoprotein 1
STK39 serine threonine kinase 39
TAL1 T-cell acute lymphocytic leukemia 1
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
THRA thyroid hormone receptor, alpha
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TLR5 toll-like receptor 5
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TRIB3 tribbles pseudokinase 3
TRPC6 transient receptor potential cation channel, subfamily C, member 6
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
WNK1 WNK lysine deficient protein kinase 1
WNK3 WNK lysine deficient protein kinase 3
WNK4 WNK lysine deficient protein kinase 4
WRN Werner syndrome, RecQ helicase-like
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZRANB2 zinc finger, RAN-binding domain containing 2