abnormal synaptic glutamate release Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors (Mammalian Phenotype Ontology, MP_0004494)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0004494
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Genes

12 gene mutations causing the abnormal synaptic glutamate release phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADGRL1 adhesion G protein-coupled receptor L1
GDI1 GDP dissociation inhibitor 1
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
NOS1 nitric oxide synthase 1 (neuronal)
NRXN1 neurexin 1
RORA RAR-related orphan receptor A
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNAP25 synaptosomal-associated protein, 25kDa
SSTR1 somatostatin receptor 1
SSTR2 somatostatin receptor 2